Elevated serum C-reactive protein as a prognostic marker in small cell lung cancer.

Abstract:

PURPOSE:Elevated C-reactive protein (CRP) is associated with poor prognosis in several tumor types. The purpose of this study was to investigate serum CRP as a prognostic marker in small cell lung cancer (SCLC). MATERIALS AND METHODS:The pretreatment serum CRP level was measured in 157 newly diagnosed SCLC patients, and correlation between serum CRP level and other clinical parameters was analyzed. Multivariate analyses were performed to find prognostic markers using Cox's proportional hazards model. RESULTS:The initial CRP concentration was within the normal range in 72 (45.9%) patients and elevated in 85 (54.1%) patients. There was a significant correlation between serum CRP level and the extent of disease (p<0.001), weight loss (p=0.029) and chest radiation (p=0.001). Median overall survival (OS) in the normal CRP group was significantly longer than with the high CRP group (22.5 months vs. 11.2 months, p<0.001). Extent of disease (p<0.001), age (p=0.025), and performance status (p<0.001) were additional prognostic factors on univariate analysis. On multivariate analysis, elevated serum CRP level was an independent prognostic factor for poor survival (HR=1.8; p=0.014), regardless of the extent of disease (HR=3.7; p<0.001) and performance status (HR=2.2; p<0.001). CONCLUSION:High level of CRP was an independent poor prognostic serum marker in addition to previously well-known prognosticators in patients with SCLC.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Hong S,Kang YA,Cho BC,Kim DJ

doi

10.3349/ymj.2012.53.1.111

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

111-7

issue

1

eissn

0513-5796

issn

1976-2437

pii

201201111

journal_volume

53

pub_type

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