Blockade of VEGFR-1 and VEGFR-2 enhances paclitaxel sensitivity in gastric cancer cells.

abstract：PURPOSE:Pharmacological inhibition of mutant isocitrate dehydrogenase (IDH) reduces R-2-hydroxyglutarate (2-HG) levels and restores cellular differentiation in vivo and in vitro. The IDH2 inhibitor enasidenib (AG-221) has been approved by the FDA as a first-in-class inhibitor for the treatment of relapsed or refractory...

journal_title：Yonsei medical journal

authors： Kim Y,Jeung HK,Cheong JW,Song J,Bae SH,Lee JI,Min YH

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:This study aimed to elucidate which echocardiographic criteria at three time points, for cardiac resynchronization therapy (CRT) response, are accurate in discriminating the hierarchical clinical composite end point (HCCEP). MATERIALS AND METHODS:We included 120 patients (age, 66.1±12.6 years; men, 54.2%) who ...

journal_title：Yonsei medical journal

authors： Uhm JS,Oh J,Cho IJ,Park M,Kim IS,Jin MN,Bae HJ,Yu HT,Kim TH,Pak HN,Lee MH,Joung B,Kang SM

更新日期：2019-01-01 00:00:00

abstract：:Brain is a logical target of free radical damage, considering the large lipid content of myelin sheaths and the high rate of brain oxidative metabolism. Thus, the hypothesis that free radicals may be involved in the pathogenesis of certain CNS diseases has gained increasing popularity in recent years. In CNS ischemia-...

journal_title：Yonsei medical journal

authors： Choi BH

更新日期：1993-03-01 00:00:00

abstract：:Coronary no-reflow is defined as inadequate myocardial perfusion of a given coronary segment without angiographic evidence of mechanical vessel obstruction. No-reflow is visualized angiographically as a reduction in thrombolysis in myocardial infarction (TIMI) flow grade and is typically accompanied by chest pain, ele...

journal_title：Yonsei medical journal

authors： Son JW,Kim JS,Lee JM,Hong SJ,Jung MK,Kim DH,Kim JS,Choi D,Jang Y

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Genes of the HoxD cluster play a major role in vertebrate limb development, and changes that modify the Hoxd12 locus affect other genes also, suggesting that HoxD function is coordinated by a control mechanism involving multiple genes during limb morphogenesis. In this study, mutant phenotypes were produced by ...

journal_title：Yonsei medical journal

authors： Cho KW,Kim JY,Cho JW,Cho KH,Song CW,Jung HS

更新日期：2008-12-31 00:00:00

abstract：PURPOSE:To compare the outcomes of thoracic endovascular aortic repair (TEVAR) with those of open repair for descending thoracic aortic aneurysms (DTAA). MATERIALS AND METHODS:We compared the outcomes of 114 patients with DTAA and proximal landing zones 3 or 4 after TEVAR to those of 53 patients after conventional ope...

journal_title：Yonsei medical journal

authors： Lee HC,Joo HC,Lee SH,Lee S,Chang BC,Yoo KJ,Youn YN

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Numerous studies have assessed the association of SP110 gene variants with tuberculosis (TB), but the results were inconsistent. Through a comprehensive review and meta-analysis, our study aimed to clarify the nature of genetic risks contributed by 11 polymorphisms for the development of TB. MATERIALS AND METH...

journal_title：Yonsei medical journal

authors： Zhang S,Wang XB,Han YD,Wang C,Zhou Y,Zheng F

更新日期：2017-01-01 00:00:00

abstract：:We evaluated and compared procedural memory and auditory P300 event-related potential in age-matched normal controls (n = 15) and drug-naive patients with Parkinson's disease (n = 16). We used Gollin's incomplete picture test for visual procedural memory function and Tower of Hanoi puzzle for visuomotor procedural mem...

journal_title：Yonsei medical journal

authors： Kim GW,Sohn YH,Huh K,Kim JS

更新日期：1995-09-01 00:00:00

abstract：PURPOSE:Landmark indicators have not yet to be developed to detect the regression of cervical intraepithelial neoplasia (CIN). We propose that quantitative viral load and indicative histological criteria can be used to differentiate between atypical squamous cells of undetermined significance (ASCUS) and a CIN of grade...

journal_title：Yonsei medical journal

authors： Lhee MJ,Cha YJ,Bae JM,Kim YT,Cho NH

更新日期：2014-03-01 00:00:00

abstract：:Hepatocytes are the primary targets of the hepatitis C virus (HCV). While immunosuppressive roles of HCV core protein have been found in several studies, it remains uncertain whether core protein expressed in hepatocytes rather than in immune cells affects the CD8+ T cell response. In order to transduce genes selectiv...

journal_title：Yonsei medical journal

authors： Jin YH,Crispe IN,Park S

更新日期：2005-12-31 00:00:00

abstract：:Anaplastic thyroid carcinoma (ATC) is one of the most malignant human neoplasms and has a grave prognosis. This study gives an update on our experience with this unusual neoplasm, with specific focus on the response to various treatment modalities. Forty-seven patients with histologically proven ATCs were enrolled (19...

journal_title：Yonsei medical journal

authors： Chang HS,Nam KH,Chung WY,Park CS

更新日期：2005-12-31 00:00:00

abstract：PURPOSE:The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations between the ALDH2 polymorphism and the risk of ALC. MATERIALS AND ME...

journal_title：Yonsei medical journal

authors： He L,Deng T,Luo H

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Pathogenesis and treatment of spontaneous dissecting aneurysm of the intracranial vertebral artery (VA) remain controversial. This study was designed to provide management strategies and to improve management outcome in patients with these aneurysms. MATERIALS AND METHODS:Among a total of 1,990 patients treate...

journal_title：Yonsei medical journal

authors： Lee JW,Jung JY,Kim YB,Huh SK,Kim DI,Lee KC

更新日期：2007-06-30 00:00:00

abstract：:Steroid cell tumors, not otherwise specified (NOS), are rare ovarian sex cord-stromal tumors with malignant potential. The majority of these tumors produce several steroids, particularly testosterone. Various virilizing symptoms such as hirsutism, temporal balding, and amenorrhea are common in these patients; however ...

journal_title：Yonsei medical journal

authors： Kim YT,Kim SW,Yoon BS,Kim SH,Kim JH,Kim JW,Cho NH

更新日期：2007-02-28 00:00:00

abstract：:Cervical cancer is a progressive disease with an onset of one to two decades on average. During the productive replication stage, the Human papillomavirus (HPV) genome is maintained episomally in the infected cervical epithelium and early gene products, including E5, are expressed. Therefore, E5 has a potential to con...

journal_title：Yonsei medical journal

authors： Kim SW,Yang JS

更新日期：2006-02-28 00:00:00

abstract：PURPOSE:Pulse wave velocity (PWV) is at least partially controlled by vascular tone. Vascular tone and underlying physiological processes such as sympathetic activity, plasma catecholamin, and cortisol levels have been shown to follow diurnal variations. MATERIALS AND METHODS:Carotid-to-radial PWV was non-invasively a...

journal_title：Yonsei medical journal

authors： Bodlaj G,Berg J,Biesenbach G

更新日期：2007-08-31 00:00:00

abstract：:A 71-year-old man was stable on warfarin (2.25 mg daily) therapy with an international normalized ratio (INR) of 1.8-2.2 after a heart valve replacement surgery. Recently, he consumed the liquid-like herbal product called shengmai-yin (10 mL daily) against medical advice. Seven days after the daily consumption of shen...

journal_title：Yonsei medical journal

authors： Su Q,Li Y

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Although time-of-flight (TOF)-magnetic resonance angiography (MRA) can clearly depict intracranial arteries, the arterial flow of middle cerebral artery (MCA) is occasionally not detected. We evaluated this phenomenon with reference to cerebrovascular dynamics. MATERIALS AND METHODS:Seventeen patients with sus...

journal_title：Yonsei medical journal

authors： Igase K,Igase M,Matsubara I,Sadamoto K

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of minimal stimulation using discretely administered gonadotropin combined with clomiphene citrate (CC) or letrozole (LTZ) for intrauterine insemination (IUI) cycles. MATERIALS AND METHODS:Total 257 IUI cycles from 158 infertile couples were assessed. A CC dose of 100 mg/day (n=126 cyc...

journal_title：Yonsei medical journal

authors： Yun BH,Chon SJ,Park JH,Seo SK,Cho S,Choi YS,Kim SH,Lee BS

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Massive blood transfusios are uncommon. The goal of this study was to propose an ideal ratio for the blood component of massive hemorrhage treatment after review of five years of massive transfusion practice, in order to have the best possible clinical outcomes. MATERIALS AND METHODS:We defined a 'massive tran...

journal_title：Yonsei medical journal

authors： Yoon S,Park AJ,Kim HO

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:Although there is a consensus about the need for surveillance colonoscopy after endoscopic resection, the interval remains controversial for large sessile colorectal polyps. The aim of this study was to evaluate the long-term outcome and the adequate surveillance colonoscopy interval required for sessile and fl...

journal_title：Yonsei medical journal

authors： Kim B,Choi AR,Park SJ,Cheon JH,Kim TI,Kim WH,Hong SP

更新日期：2016-09-01 00:00:00

abstract：:Colorectal cancers (CRC)--and probably all cancers--are caused by alterations in genes. This includes activation of oncogenes and inactivation of tumor suppressor genes (TSGs). There are many ways to achieve these alterations. Oncogenes are frequently activated by point mutation, gene amplification, or changes in the ...

journal_title：Yonsei medical journal

authors： Boland CR,Shin SK,Goel A

更新日期：2009-06-30 00:00:00

abstract：:To report a non-fatal case of reperfusion pulmonary edema (RPE) after the removal of a hepatocellular carcinoma embolus, which had caused an acute obstruction of the tricuspid valve and pulmonary vasculature during a hepatic lobectomy. Pulmonary embolism caused by hepatocellular carcinoma embolus is extremely rare, an...

journal_title：Yonsei medical journal

authors： Lee JM,Lee HJ,Kim ES

更新日期：2006-04-30 00:00:00

abstract：:The spinal motonucleus of the genitofemoral nerve regulating scrotal temperature can also be related to prenatal and neonatal testicular descent by gubernacular change in rats, and a sexually dimorphic-like bulbocavernosus/dorsolateral motonucleus. There is a hypothesis that neonatal androgen affects these motonuclei,...

journal_title：Yonsei medical journal

authors： Han SW,Rha KH,Lee WT,Mah SY,Choi HK,Choi SK

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:Plasma levels of renin, angiotensin II and aldosterone are increased during normal pregnancy. However, these values in preeclampsia are decreased to nearly that of a nonpregnant subject, and vascular sensitivity to angiotensin II is increased. In preeclampsia, aldosterone is decreased less than rennin. Therefor...

journal_title：Yonsei medical journal

authors： Kim EH,Lim JH,Kim YH,Park YW

更新日期：2008-02-29 00:00:00

abstract：PURPOSE:The aim of this study was to identify the adipocyte-specific gene expression patterns in chorion-derived mesenchymal stem cells during adipogenic differentiation. MATERIALS AND METHODS:Chorionic cells were isolated from the third trimester chorions from human placenta at birth and identified morphologically an...

journal_title：Yonsei medical journal

authors： Kim YH,Park TC,Lee G,Shin JC

更新日期：2012-09-01 00:00:00

abstract：:¹⁸F-AV-1451 is a tau PET ligand that has high affinity for paired helical filament tau. However, various off-target bindings unrelated to tau have also been reported. Herein, we report a case of 83-year-old woman, who showed abnormal uptake of AV-1451 that was shown to be subacute infarction. Clinicians should recogni...

journal_title：Yonsei medical journal

authors： Cho SH,Cho H,Park S,Ryu YH,Choi JY,Lyoo CH,Na DL,Seo SW,Kim HJ

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To overcome the potential disadvantages of the use of foreign materials and autologous fat or collagen, we introduce here an autologous plasma gel for injection laryngoplasty. The purpose of this study was to present a new injection material, a plasma gel, and to discuss its clinical effectiveness. MATERIALS A...

journal_title：Yonsei medical journal

authors： Woo SH,Kim JP,Park JJ,Chung PS,Lee SH,Jeong HS

更新日期：2013-11-01 00:00:00

abstract：:Pyogenic sacroiliitis is a relatively rare condition that often leads to surgical treatment, including debridement and arthrodesis. Here we introduce a new surgical technique using bilateral dual iliac screws to secure early ambulation and maximal fusion success rate for the treatment of pyogenic sacroiliitis. We retr...

journal_title：Yonsei medical journal

authors： Kwon JW,Shin JK,Moon SH,Lee HM,Lee BH

更新日期：2020-02-01 00:00:00

abstract：:Echocardiographic automatic boundary detection (ABD) is a new on-line technique which automatically outlines the left ventricular endocardial border and instantly calculates the left ventricular area and volume from two dimensional echocardiographic images. To determine if left ventricular ejection fraction (LVEF) can...

journal_title：Yonsei medical journal

authors： Ha JW,Chung N,Choe KH,Kwan J,Rim SJ,Jang Y,Kim JY,Oh EK,Lee YJ,Shim WH,Cho SY,Kim SS

更新日期：1996-12-01 00:00:00