Expression of hepatitis C virus core protein in hepatocytes does not modulate proliferation or apoptosis of CD8+ T cells.

Abstract:

:Hepatocytes are the primary targets of the hepatitis C virus (HCV). While immunosuppressive roles of HCV core protein have been found in several studies, it remains uncertain whether core protein expressed in hepatocytes rather than in immune cells affects the CD8+ T cell response. In order to transduce genes selectively into hepatocytes, we developed a baculoviral vector system that enabled primary hepatocytes to express a target epitope for CD8+ T cells, derived from ovalbumin (OVA), with or without HCV core protein. Culture of OVA-specific CD8+ T cells with hepatocytes infected with these baculoviral vectors revealed that core protein has no effect on proliferation or apoptosis of CD8+ T cells. Our results suggest that HCV core protein does not exert its suppressive role on the CD8+ T cell immune response through expression in hepatocytes.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Jin YH,Crispe IN,Park S

doi

10.3349/ymj.2005.46.6.827

keywords:

subject

Has Abstract

pub_date

2005-12-31 00:00:00

pages

827-34

issue

6

eissn

0513-5796

issn

1976-2437

pii

200512827

journal_volume

46

pub_type

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