Abstract:
PURPOSE:Genes of the HoxD cluster play a major role in vertebrate limb development, and changes that modify the Hoxd12 locus affect other genes also, suggesting that HoxD function is coordinated by a control mechanism involving multiple genes during limb morphogenesis. In this study, mutant phenotypes were produced by treatment of mice with a chemical mutagen, N-ethyl-N-nitrosourea (ENU). We analyzed mutant mice exhibiting the specific microdactyly phenotype and examined the genes affected. MATERIALS AND METHODS:We focused on phenotype characteristics including size, bone formation, and digit morphology of ENU-induced microdactyly mice. The expressions of several molecules were analyzed by genome-wide screening and quantitative real-time PCR to define the affected genes. RESULTS:We report on limb phenotypes of an ENU-induced A-to-C mutation in the Hoxd12 gene, resulting in alanine-to-serine conversion. Microdactyly mice exhibited growth defects in the zeugopod and autopod, shortening of digits, a missing tip of digit I, limb growth affected, and dramatic increases in the expressions of Fgf4 and Lmx1b. However, the expression level of Shh was not changed in Hoxd12 point mutated mice. CONCLUSION:These results suggest that point mutation rather than the entire deletion of Hoxd12, such as in knockout and transgenic mice, causes the abnormal limb phenotype in microdactyly mice. The precise nature of the spectrum of differences requires further investigation.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Cho KW,Kim JY,Cho JW,Cho KH,Song CW,Jung HSdoi
10.3349/ymj.2008.49.6.965subject
Has Abstractpub_date
2008-12-31 00:00:00pages
965-72issue
6eissn
0513-5796issn
1976-2437pii
200812965journal_volume
49pub_type
杂志文章abstract::Although cysticercosis is the most common parasitic disease affecting the central nervous system, spinal cysticercosis is rare. A rare form of spinal cysticercosis involving the whole spinal canal is presented. A 45-year-old Korean male had a history of intracranial cysticercosis and showed progressive paraparesis. Sp...
journal_title:Yonsei medical journal
pub_type: 杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1998.39.6.534
更新日期:1998-12-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3349/ymj.1998.39.3.247
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2007.48.6.1043
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pub_type: 临床试验,杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1991.32.2.147
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,评审
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