Disruption of the Gut Ecosystem by Antibiotics.

Abstract:

:The intestinal microbiota is a complex ecosystem consisting of various microorganisms that expands human genetic repertoire and therefore affects human health and disease. The metabolic processes and signal transduction pathways of the host and intestinal microorganisms are intimately linked, and abnormal progression of each process leads to changes in the intestinal environment. Alterations in microbial communities lead to changes in functional structures based on the metabolites produced in the gut, and these environmental changes result in various bacterial infections and chronic enteric inflammatory diseases. Here, we illustrate how antibiotics are associated with an increased risk of antibiotic-associated diseases by driving intestinal environment changes that favor the proliferation and virulence of pathogens. Understanding the pathogenesis caused by antibiotics would be a crucial key to the treatment of antibiotic-associated diseases by mitigating changes in the intestinal environment and restoring it to its original state.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Yoon MY,Yoon SS

doi

10.3349/ymj.2018.59.1.4

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

4-12

issue

1

eissn

0513-5796

issn

1976-2437

pii

59.4

journal_volume

59

pub_type

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