Abstract:
PURPOSE:Non-alcoholic fatty liver disease (NAFLD) is independently associated with the development of atrial fibrillation (AF). However, the association of AF with advanced liver fibrosis, which is related to all-cause, cardiovascular, and liver-related mortality, has not been established in NAFLD patients. We aimed to investigate the association between AF and advanced liver fibrosis in NAFLD patients. MATERIALS AND METHODS:Out of 53704 adults who participated in the health check-up program, 6293 subjects aged 35 years and older were diagnosed as NAFLD using ultrasound. The stage of liver fibrosis was assessed based on the newly adjusted NAFLD fibrosis score (NFS) and Fibrosis-4 (Fib-4) Index, which were used to determine the low and high cut-off values (COVs). RESULTS:Of 6293 patients with NAFLD, 59 (0.9%) were diagnosed with AF. Patients with AF were older (52.0 vs. 64.6 years, p<0.001), had higher body mass index (25.2 vs. 26.6 kg/m², p<0.001), and had bigger waist circumference (84.0 vs. 89.9 cm, p<0.001) than those without AF. In NAFLD patients, AF was independently associated with advanced liver fibrosis, assessed using both COVs of NFS [low-COV group: final adjusted odds ratios (aORs)=2.85, p=0.004; high-COV group: ORs=12.29, p<0.001). AF was independently associated with advanced liver fibrosis, assessed using both COVs of Fib-4 (low-COV group: aORs=2.49, p<0.001; high-COV group: aORs=3.84, p=0.016). CONCLUSION:AF is independently associated with advanced liver fibrosis in patients with NAFLD.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Kang MK,Park JG,Kim MCdoi
10.3349/ymj.2020.61.10.860subject
Has Abstractpub_date
2020-10-01 00:00:00pages
860-867issue
10eissn
0513-5796issn
1976-2437pii
61.860journal_volume
61pub_type
杂志文章abstract::Helicobacter pylori (H. pylori) undergoes decades long colonization of the gastric mucosa of half the population in the world to produce acute and chronic gastritis at the beginning of infection, progressing to more severe disorders, including peptic ulcer disease and gastric cancer. Prolonged carriage of H. pylori is...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2014.55.6.1453
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
pub_type: 杂志文章,meta分析
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doi:10.3349/ymj.2004.45.4.743
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journal_title:Yonsei medical journal
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doi:10.3349/ymj.1995.36.1.89
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2006.47.6.877
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journal_title:Yonsei medical journal
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doi:10.3349/ymj.2001.42.5.576
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journal_title:Yonsei medical journal
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doi:10.3349/ymj.2015.56.6.1651
更新日期:2015-11-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1999.40.2.159
更新日期:1999-04-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2010.51.3.375
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journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2013.54.2.301
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2001.42.4.451
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2003.44.5.757
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journal_title:Yonsei medical journal
pub_type: 杂志文章,收录出版
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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pub_type: 已发布勘误
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journal_title:Yonsei medical journal
pub_type: 杂志文章,随机对照试验
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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