Abstract：
PURPOSE:Numerous studies have assessed the association of SP110 gene variants with tuberculosis (TB), but the results were inconsistent. Through a comprehensive review and meta-analysis, our study aimed to clarify the nature of genetic risks contributed by 11 polymorphisms for the development of TB. MATERIALS AND METHODS:Through searching PubMed, web of science, China National Knowledge Infrastructure (CNKI) databases, a total of 11 articles including 13 independent studies were selected. The pooled odd ratios (ORs) along with their corresponding 95% confidence interval (CI) were estimated for allelic comparisons, additive model (homozygote comparisons; heterozygote comparisons), dominant model and recessive model. We also assessed the heterogeneity across the studies and publication bias. RESULTS:The results of combined analysis revealed a significantly increased risk of TB for single nucleotide polymorphism (SNP) rs9061 in all five comparisons (allelic comparisons: OR=1.28, 95% CI=1.14-1.44, p<0.0001; homozygote comparisons: OR=2.84, 95% CI=1.84-4.38, p<0.00001; heterozygote comparisons: OR=1.23, 95% CI=1.05-1.43, p=0.009; dominant model: OR=1.32, 95% CI=1.14-1.53, p=0.0003; recessive model: OR=2.26, 95% CI=1.18-4.34, p=0.01). In subgroup analysis, the risk of TB associated with SNP rs9061 appeared to be increased. Moreover, increased risk of TB was also found in Asian subgroup of SNP rs11556887, while decreased risk of TB appeared in large sample size subgroup of SNP rs1135791. No significant association was observed between other SNPs and the risk of TB. CONCLUSION:Our meta-analysis suggested that the variant of SNP rs9061 might be a risk factor for TB.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Zhang S,Wang XB,Han YD,Wang C,Zhou Y,Zheng Fdoi
10.3349/ymj.2017.58.1.165subject
Has Abstractpub_date
2017-01-01 00:00:00pages
165-173issue
1eissn
0513-5796issn
1976-2437pii
58.165journal_volume
58pub_type
杂志文章,meta分析,评审abstract：PURPOSE:To report long term treatment outcomes of osteofibrous dysplasia and association with adamantinoma. PATIENTS AND METHODS:From January 1984 to July 2001, 14 patients with osteofibrous dysplasia were followed for an average of 108 months (78 to 260 months). Our patient group consisted of 6 men and 8 women, with ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2007.48.3.502
更新日期：2007-06-30 00:00:00
abstract：PURPOSE:To estimate long-term outcomes after treatment modification in patients with chronic hepatitis B (CHB) treated with entecavir (ETV) and telbivudine (LdT). MATERIALS AND METHODS:The study enrolled 131 nucleos(t)ide analogue (NA)-naïve CHB patients treated with ETV or LdT. During the 3-year study, NA treatment h...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2018.59.3.383
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:To determine and compare the clinical characteristics, visual prognosis and treatment of hemorrhagic polypoidal choroidal vasculopathy (HPCV) with those of hemorrhagic choroidal neovascularization (HCNV) due to age-related macular degeneration (ARMD). MATERIALS AND METHODS:Retrospective analysis of 44 consecut...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2007.48.2.225
更新日期：2007-04-30 00:00:00
abstract：PURPOSE:Although there is a consensus about the need for surveillance colonoscopy after endoscopic resection, the interval remains controversial for large sessile colorectal polyps. The aim of this study was to evaluate the long-term outcome and the adequate surveillance colonoscopy interval required for sessile and fl...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2016.57.5.1106
更新日期：2016-09-01 00:00:00
abstract：:Many features of the developing nervous system are visible from external observations of intact human embryos. In this study, a photographic atlas from the 4th to the 7th week after ovulation (Carnegie stages 10-18) is provided. The neural folds began to fuse at stage 10, and the rostral and caudal neuropore were clos...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1997.38.1.26
更新日期：1997-02-01 00:00:00
abstract：PURPOSE:We evaluated the validity of robotic surgery (RS) for pediatric choledochal cyst (CC) in comparison to open surgery (OS). MATERIALS AND METHODS:From January 2009 to April 2013, clinical data from 79 consecutive pediatric patients with CC, who underwent RS (n=36) or OS (n=43) performed by a single pediatric sur...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2015.56.3.737
更新日期：2015-05-01 00:00:00
abstract：:Although cytologic screening has considerably reduced the incidence of cervical cancer, there are some problems which remain to be solved, such as the low sensitivity of this procedure. HPV testing is fundamentally different from conventional cytologic testing, because it evaluates the HPV infection itself, the most i...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2002.43.6.763
更新日期：2002-12-01 00:00:00
abstract：:The human major histocompatibility complex HLA is located on the short arm of chromosome 6. It is known to be the most polymorphic genetic system in humans. The biological role of the HLA class I and class II molecules is to present processed peptide antigens. The HLA system is clinically important as transplantation ...
journal_title：Yonsei medical journal
pub_type： 杂志文章,评审
doi：10.3349/ymj.2007.48.1.11
更新日期：2007-02-28 00:00:00
abstract：:A few approaches can be used to decompress traumatic facial nerve paralysis including the middle cranial fossa approach or transmastoid approach depending on the site of injury. In some specific situation of treating traumatic facial nerve palsy whose injured site was confined from the geniculate ganglion to the secon...
journal_title：Yonsei medical journal
pub_type：
doi：10.3349/ymj.2018.59.3.457
更新日期：2018-05-01 00:00:00
abstract：:The present study compares neonatal outcome after preterm delivery of infants in pregnancies complicated by the HELLP syndrome or severe preeclampsia (PS). The maternal and neonatal charts of 71 out of a total of 409 pregnancies that were complicated by hypertensive disorders at Severance hospital between January 1995...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2006.47.3.393
更新日期：2006-06-30 00:00:00
abstract：:Behçet's disease is characterized with multifactorial etiopathogenesis and multiclinical pictures. The treatment of patients with Behçet's disease is based on the severity of illness, and the most appropriate management of Behçet's disease requires a multidisciplinary approach. Although various therapeutic modalities ...
journal_title：Yonsei medical journal
pub_type： 杂志文章,评审
doi：10.3349/ymj.1997.38.6.401
更新日期：1997-12-01 00:00:00
abstract：PURPOSE:To investigate the relationship between prostate volume and the increased risk for being diagnosed with prostate cancer (PCa) in men with slowly increasing prostate specific antigen (PSA). MATERIALS AND METHODS:A cohort of 1035 men who visited our hospital's health promotion center and were checked for serum P...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2013.54.5.1202
更新日期：2013-09-01 00:00:00
abstract：:Colorectal cancers (CRC)--and probably all cancers--are caused by alterations in genes. This includes activation of oncogenes and inactivation of tumor suppressor genes (TSGs). There are many ways to achieve these alterations. Oncogenes are frequently activated by point mutation, gene amplification, or changes in the ...
journal_title：Yonsei medical journal
pub_type： 杂志文章,评审
doi：10.3349/ymj.2009.50.3.309
更新日期：2009-06-30 00:00:00
abstract：:The overall prognosis of gastric cancer has gradually improved over the past decades with growing awareness of potential carcinogens, surveillance programs and early diagnosis, as well as advances in surgical techniques and multimodality treatments. Nevertheless, the outcome of advanced stage disease still remains poo...
journal_title：Yonsei medical journal
pub_type： 杂志文章,评审
doi：10.3349/ymj.2012.53.2.248
更新日期：2012-03-01 00:00:00
abstract：:Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for con...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1996.37.2.97
更新日期：1996-04-01 00:00:00
abstract：:The purpose of this study was to determine the factors which were responsible for delaying early diagnosis and optimal management of rheumatoid arthritis (RA) in Korea. We interviewed 109 outpatients diagnosed as RA being treated by rheumatologists, and we eventually analyzed 98 patients' data. The median length of ti...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1998.39.3.247
更新日期：1998-06-01 00:00:00
abstract：:The spinal motonucleus of the genitofemoral nerve regulating scrotal temperature can also be related to prenatal and neonatal testicular descent by gubernacular change in rats, and a sexually dimorphic-like bulbocavernosus/dorsolateral motonucleus. There is a hypothesis that neonatal androgen affects these motonuclei,...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1998.39.1.13
更新日期：1998-02-01 00:00:00
abstract：PURPOSE:Decision to perform concurrent ipsilateral thyroidectomy on patients with hypopharyngeal cancer is important, and unnecessary thyroidectomy should be avoided if oncologically feasible. We hypothesized that concurrent ipsilateral thyroidectomy is not routinely required to prevent occult metastasis. This study ai...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2015.56.3.812
更新日期：2015-05-01 00:00:00
abstract：:A 50-year-old peri-menopausal woman presented with hard palpable mass on her lower abdomen and anemia from heavy menstrual bleeding. Ultrasonography showed a 13×12 cm sized hypoechoic solid mass in pelvis and a 2.5×2 cm hypoechoic cystic mass in uterine endometrium. Abdomino-pelvic computed tomography revealed a hypod...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2016.57.2.523
更新日期：2016-03-01 00:00:00
abstract：:Long QT syndrome is associated with lethal tachyarrhythmia that can lead to syncope, seizure, and sudden death. Congenital long QT syndrome is a genetic disorder, characterized by delayed cardiac repolarization and prolongation of the QT interval on the electrocardiogram (ECG). Type 2 congenital long QT is linked to m...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2011.52.6.1025
更新日期：2011-11-01 00:00:00
abstract：:We evaluated the one-stage intraoperative adjustment strabismus surgery with adjustable suture under topical anesthesia. Medical records of the patients who had intraoperative adjustment surgery under topical anesthesia for horizontal or vertical strabismus in our hospital from March 1997 to March 2003 with follow-up ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2006.47.5.667
更新日期：2006-10-31 00:00:00
abstract：:The aim of this research was to estimate the community prevalence of alcoholism and the potential risk factors that affect it in the Edirne provincial centre by using a scanning test. A cross-sectional study was carried out in the Edirne provincial centre. A sample population composed of 500 women and 200 men was sele...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2004.45.2.207
更新日期：2004-04-30 00:00:00
abstract：PURPOSE:The aim of this study was to investigate whether the peroxisomal proliferator-activated receptor gamma (PPARγ) ligand troglitazone in combination with photodynamic therapy (PDT) enhances the apoptotic response of DLD-1 colon cancer cells. MATERIALS AND METHODS:The effects of troglitazone, PDT, and troglitazone...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2016.57.6.1494
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the effect of incentive spirometer exercise (ISE) on pulmonary function and maximal phonation time (MPT) in children with spastic cerebral palsy (CP). MATERIALS AND METHODS:Fifty children with CP were randomly assigned to two groups: the experimental group and the contr...
journal_title：Yonsei medical journal
pub_type： 杂志文章,随机对照试验
doi：10.3349/ymj.2016.57.3.769
更新日期：2016-05-01 00:00:00
abstract：PURPOSE:Exclusive enteral nutrition (EEN) therapy effectively induces clinical remission in Crohn's disease (CD). It remains unclear, however, whether partial enteral nutrition (PEN) can maintain remission. This study was performed to determine the abilities of oral EEN and oral PEN to induce and maintain clinical remi...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2016.57.5.1185
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:This study aimed to investigate whether Müllerian inhibiting substance (MIS) in combination with calcitriol modulates proliferation and apoptosis of human ovarian cancer (OCa) cell lines (SKOV3, OVCAR3, and OVCA433) and identify the signaling pathway by which MIS mediates apoptosis. MATERIALS AND METHODS:OCa c...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2016.57.1.33
更新日期：2016-01-01 00:00:00
abstract：:Transient myocardial ischemia during cardiac surgery causes a loss of energy sources, contractile depression, and accumulation of metabolites and H+ ion resulting in intracellular acidosis. The reperfusion following ischemic cardioplegia recovers intracellular pH, activates Na+-H+ exchange and Na+-Ca2+ exchange transp...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2001.42.3.333
更新日期：2001-06-01 00:00:00
abstract：:Retinoic acid receptor-beta (RAR-beta) is induced by and mediates the growth-inhibitory and apoptotic effects of retinoic acid (RA), suggesting that loss of RAR-beta expression may be one of the critical events involved in the carcinogenesis/ progression of non-small cell lung cancer (NSCLC) and in the responsiveness ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2004.45.3.435
更新日期：2004-06-30 00:00:00
abstract：PURPOSE:The present study aimed to evaluate the efficacy and safety of polymer-free drug-coated BioFreedom stent implantation in comparison to coronary artery bypass graft (CABG) before major noncardiac surgery. MATERIALS AND METHODS:In a multicenter registry, 55 patients required revascularization before major noncar...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2018.59.4.480
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:Since 1993, Koreans have used diagnostic criteria set by the Korean Society on Thrombosis and Hemostasis (KSTH) in the diagnosis of overt disseminated intravascular coagulation (DIC). In 2001, the Scientific and Standardization Committee (SCC) of the International Society on Thrombosis and Hemostasis (ISTH) pro...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2007.48.4.595
更新日期：2007-08-31 00:00:00
