The HLA system: genetics, immunology, clinical testing, and clinical implications.

Abstract:

:The human major histocompatibility complex HLA is located on the short arm of chromosome 6. It is known to be the most polymorphic genetic system in humans. The biological role of the HLA class I and class II molecules is to present processed peptide antigens. The HLA system is clinically important as transplantation antigens. Molecular HLA allele typing is routinely performed to provide HLA class I and class II allele matching in unrelated donor hematopoietic stem cell transplantation. Prospective lymphocyte crossmatching is critical in solid organ transplantation to prevent allograft rejection. HLA alloimmunization causes various problems in transfusion therapy. The HLA system is associated with certain diseases, but its underlying mechanisms are not yet fully explained.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Choo SY

doi

10.3349/ymj.2007.48.1.11

subject

Has Abstract

pub_date

2007-02-28 00:00:00

pages

11-23

issue

1

eissn

0513-5796

issn

1976-2437

pii

200702011

journal_volume

48

pub_type

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