Abstract:
:With growing evidence of an increase in the prevalence, food allergy has been emerged as a new public health problem. As treatment and management of food allergy remain challenging, more attention has been paid to the importance of prevention of food allergy. Although the exact mechanism of recent epidemic is not fully understood, it is suggested that nutritional exposure in early life may play an important role in food allergy development. The underlying hypothesis is that nutritional status or food exposure in the critical period of fetal development can affect the programming of immune system and modify the risk of immunologic reactions to foods in postnatal life. We review accumulating epidemiological studies to examine an association between nutritional exposure during pregnancy or early infancy and food allergy development in children. We also discuss recent advances in the studies of the genetic and epigenetic regulation of food allergy and evaluate the role of early nutrition in food allergy development to provide a new perspective on the prevention of food allergy.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Lee SE,Kim Hdoi
10.3349/ymj.2016.57.3.542subject
Has Abstractpub_date
2016-05-01 00:00:00pages
542-8issue
3eissn
0513-5796issn
1976-2437pii
57.542journal_volume
57pub_type
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