Rethinking statistical approaches to evaluating drug safety.

abstract：PURPOSE:Data comparing the clinical benefits of medical treatment with those of percutaneous coronary intervention (PCI) in an elderly population with angina pectoris are limited. Therefore, we evaluated the efficacy of elective PCI versus optimal medical treatment (OMT) in elderly patients (between 75 and 84 years old...

journal_title：Yonsei medical journal

authors： Won H,Her AY,Kim BK,Kim YH,Shin DH,Kim JS,Ko YG,Choi D,Kwon HM,Jang Y,Hong MK

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:The treatment of a clinically node-positive (cN+) neck is important in the management of oral cavity squamous cell carcinoma (OSCC). However, the extent of neck dissection (ND) remains controversial. The purpose of our study was to evaluate whether level IV or V can be excluded in therapeutic ND for cN+ OSCC pa...

journal_title：Yonsei medical journal

authors： Shin YS,Koh YW,Kim SH,Choi EC

更新日期：2013-01-01 00:00:00

abstract：:The concept of cell transplantation using tissue engineering techniques has provided numerous possibilities in the area of urologic tissue reconstruction. Tissue engineering applications in the genitourinary tract system have been investigated in almost every tissue in order to improve, restore and replace existing ti...

journal_title：Yonsei medical journal

authors： Yoo JJ,Atala A

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:To evaluate reliability of Fourier-domain optical coherence tomography (OCT) (RTVue), time-domain OCT (Visante), and slit-lamp adapted ultrasonic pachymetry (SL-US) in the measurement of central corneal thickness (CCT). MATERIALS AND METHODS:Thirty healthy volunteers visited our clinic 3 times and fifty eyes w...

journal_title：Yonsei medical journal

authors： Hong JP,Nam SM,Kim TI,Seo KY,Lee SY,Meduri A,Kim EK

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:Although follicular thyroid cancer (FTC) has a relatively fair prognosis, distant metastasis sometimes results in poor prognosis and survival. There is little understanding of the mechanisms contributing to the aggressiveness potential of thyroid cancer. We showed that hypoxia inducible factor-1α (HIF-1α) induc...

journal_title：Yonsei medical journal

authors： Yang YJ,Na HJ,Suh MJ,Ban MJ,Byeon HK,Kim WS,Kim JW,Choi EC,Kwon HJ,Chang JW,Koh YW

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:This study aimed to explore the effects and mechanisms of long non-coding RNA (lncRNA) anti-differentiation non-coding RNA (ANCR) on the osteogenesis of osteoblast cells in postmenopausal osteoporosis (PMOP). MATERIALS AND METHODS:Mice models of PMOP were established. ANCR expression and intracellular calcium ...

journal_title：Yonsei medical journal

authors： Cai N,Li C,Wang F

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:The conventional trocar and cannula method in peritoneal dialysis (PD) catheter insertion has its limitation in clinical setting. The aim of this study was to compare a modified method for percutaneous PD catheter insertion with the conventional method, and demonstrate advantages of the modified method. MATERI...

journal_title：Yonsei medical journal

authors： Lee YK,Yang PS,Park KS,Choi KH,Kim BS

更新日期：2015-07-01 00:00:00

abstract：:Brucellosis is a disease involving the lymphoproliferative system, which may lead to changes in the hematological parameters; however, pancytopenia is a rare finding. However, malignant diseases in association with brucellosis are rarely the cause of pancytopenia. Herein, two cases with fever and pancytopenia, diagnos...

journal_title：Yonsei medical journal

authors： Eser B,Altuntas F,Soyuer I,Er O,Canoz O,Coskun HS,Cetin M,Unal A

更新日期：2006-10-31 00:00:00

abstract：:Stage IV-S neuroblastoma, characterized by a primary tumor plus disseminated tumors in liver, skin and bone marrow, has a favorable clinical prognosis when compared to metastatic Stage IV neuroblastoma. This favorable outcome also characterized mice receiving tumor transplants to these "IV-S" sites. We report the test...

journal_title：Yonsei medical journal

authors： Choi SH,Lim TS,Hwang EH

更新日期：1992-09-01 00:00:00

abstract：PURPOSE:Stroke is the second leading cause of death and a major cause of morbidity and mortality worldwide. Evidence of variations in adiponectin (AdipoQ) genes that are associated with ischemic stroke has not been consistent, and it is unclear whether the same loci contribute to these associations in the Korean popula...

journal_title：Yonsei medical journal

authors： Cheong MY,Bang OS,Cha MH,Park YK,Kim SH,Kim YJ

更新日期：2011-01-01 00:00:00

abstract：:We report a case of a 25-month-old girl presented to us for the evaluation of a severe delayed psychomotor development who also has pigmentary abnormalities. Linear and whorled hyperpigmentations following Blaschko's lines were noticed on her entire body except on her face, palms, soles, eyes and mucous membranes, whi...

journal_title：Yonsei medical journal

authors： Yim SY,Lee IY,Rah UW,Moon HW,Hahn SH,Lee ES,Yim HL

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:Elevated C-reactive protein (CRP) is associated with poor prognosis in several tumor types. The purpose of this study was to investigate serum CRP as a prognostic marker in small cell lung cancer (SCLC). MATERIALS AND METHODS:The pretreatment serum CRP level was measured in 157 newly diagnosed SCLC patients, a...

journal_title：Yonsei medical journal

authors： Hong S,Kang YA,Cho BC,Kim DJ

更新日期：2012-01-01 00:00:00

abstract：:Strength training is one of the most common exercises practiced in the field of physical therapy or sports training. However, limited methodology is available to evaluate its effect on the target muscle. This study aimed to test the hypothesis that surface electromyographic (EMG) data from both isometric and isotonic ...

journal_title：Yonsei medical journal

authors： Shin HK,Cho SH,Lee YH,Kwon OY

更新日期：2006-02-28 00:00:00

abstract：PURPOSE:To investigate 100 consecutive cases of videoscopic retrograde intrarenal surgery (RIRS) by a single surgeon and to evaluate factors associated with stone-free status and the learning curve thereof. MATERIALS AND METHODS:We analyzed the results of videoscopic RIRS in 100 patients who underwent primary treatmen...

journal_title：Yonsei medical journal

authors： Jeong JY,Kim JC,Kang DH,Lee JY

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Although time-of-flight (TOF)-magnetic resonance angiography (MRA) can clearly depict intracranial arteries, the arterial flow of middle cerebral artery (MCA) is occasionally not detected. We evaluated this phenomenon with reference to cerebrovascular dynamics. MATERIALS AND METHODS:Seventeen patients with sus...

journal_title：Yonsei medical journal

authors： Igase K,Igase M,Matsubara I,Sadamoto K

更新日期：2018-01-01 00:00:00

abstract：:Dendritic cells (DCs) play a pivotal role in T cell-mediated immunity and have been shown to induce strong antitumor immune responses in vitro and in vivo. Various approaches utilizing different vaccine cell formats, cell numbers, vaccination schedule, site of vaccination and maturation stages of DCs were investigated...

journal_title：Yonsei medical journal

authors： Song SY,Kim HS

更新日期：2004-06-30 00:00:00

abstract：:The purpose of this study was to compare the perioperative complication rates of reconstructive pelvic surgery and general gynecologic surgery, and to identify the predictive risk factors for perioperative complications in reconstructive pelvic surgery. The medical records of 148 reconstructive pelvic surgery patients...

journal_title：Yonsei medical journal

authors： Bai SW,An JM,Shin JS,Park JH,Kim SK,Park KH

更新日期：2004-04-30 00:00:00

abstract：:This study proposed an assessment of the correlation of hand bone mineral density measured by dual energy x-ray absorbtiometry (DXA) with the carpo:metacarpal (C:MC) ratio and metacarpal cortical index (CI) in patients with rheumatoid arthritis (RA). The correlation of total hand BMD, CI and C:MC ratio with BMD at oth...

journal_title：Yonsei medical journal

authors： Ozgocmen S,Karaoglan B,Kocakoc E,Ardicoglu O,Yorgancioglu ZR

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:Patients with chronic kidney disease frequently show cognitive dysfunction. The association of depression and cognitive function is not well known in maintenance dialysis patients. We evaluated cognitive impairment and depression, as well as their relationship in regards to methods of dialysis, maintenance hemo...

journal_title：Yonsei medical journal

authors： Jung S,Lee YK,Choi SR,Hwang SH,Noh JW

更新日期：2013-11-01 00:00:00

abstract：:We undertook this study to assess the patterns of regional cerebral perfusion (RCP) with SPECT using Technetium- 99m-ethyl cysteinate dimer (Tc-99m-ECD) in children with Tourette's Syndrome (TS), and to compare these with the patterns in a group of normal controls. The study sample consisted of 38 children (7 to 14 ye...

journal_title：Yonsei medical journal

authors： Diler RS,Reyhanli M,Toros F,Kibar M,Avci A

更新日期：2002-08-01 00:00:00

abstract：:Recent studies have been reported the roles of the estrogen receptor (ER), progesterone receptor (PR) and p53 in the development of a pelvic organ prolapse (POP). The pathogenesis of stress urinary incontinence (SUI) is related to that of POP in the weakness of pelvic support. Therefore, this study was carried out to ...

journal_title：Yonsei medical journal

authors： Bai SW,Jung YW,Kwon HS,Yoon JM,Shin JS,Kim SK,Park KH,Park JH

更新日期：2004-10-31 00:00:00

abstract：PURPOSE:The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations between the ALDH2 polymorphism and the risk of ALC. MATERIALS AND ME...

journal_title：Yonsei medical journal

authors： He L,Deng T,Luo H

更新日期：2016-07-01 00:00:00

abstract：:Leptin, a peptide hormone secreted by adipocytes in proportion of the amount of energy stored in fat, plays a central role in regulating human energy homeostasis. In addition, leptin plays a significant permissive role in the physiological regulation of several neuroendocrine axes, including the hypothalamic-pituitary...

journal_title：Yonsei medical journal

authors： Khan SM,Hamnvik OP,Brinkoetter M,Mantzoros CS

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:Hypoxemia during one-lung ventilation (OLV) remains a serious problem, particularly in the supine position. We investigated the effects of alveolar recruitment (AR) and positive end-expiratory pressure (PEEP) on oxygenation during OLV in the supine position. MATERIALS AND METHODS:Ninety-nine patients were rand...

journal_title：Yonsei medical journal

authors： Choi YS,Bae MK,Kim SH,Park JE,Kim SY,Oh YJ

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To analyze the feasibility of unilateral and bilateral translaminar screw placement in Koran population, and compare the acceptance rate using previously reported data in American population. MATERIALS AND METHODS:The translaminar lengths, thickness, heights, and sagittal-diagonal measurements were performed. ...

journal_title：Yonsei medical journal

authors： Ji GY,Oh CH,Park SH,Kurniawan F,Lee J,Jeon JK,Shin DA,Kim KN

更新日期：2015-01-01 00:00:00

abstract：:Anaplastic thyroid carcinoma (ATC) is one of the most malignant human neoplasms and has a grave prognosis. This study gives an update on our experience with this unusual neoplasm, with specific focus on the response to various treatment modalities. Forty-seven patients with histologically proven ATCs were enrolled (19...

journal_title：Yonsei medical journal

authors： Chang HS,Nam KH,Chung WY,Park CS

更新日期：2005-12-31 00:00:00

abstract：PURPOSE:Alpha-fetoprotein (AFP) is a prognostic marker for hepatocellular carcinoma (HCC). We investigated the prognostic value of AFP levels in patients who achieved complete response (CR) to transarterial chemoembolization (TACE) for HCC. MATERIALS AND METHODS:Between 2005 and 2018, 890 patients with HCC who achieve...

journal_title：Yonsei medical journal

authors： Lee JS,Chon YE,Kim BK,Park JY,Kim DY,Ahn SH,Han KH,Kang W,Choi MS,Gwak GY,Paik YH,Lee JH,Koh KC,Paik SW,Kim HY,Kim TH,Yoo K,Ha Y,Kim MN,Lee JH,Hwang SG,Kim SS,Cho HJ,Cheong JY,Cho SW,Park SH,Heo NY,H

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Genetic factors are known to be important in the etiology of bipolar disorder (BD). The fragile sites (FSs) are a very interesting subject for the study of clinical disorders. The aim of this study was to evaluate fragile sites seen in patients with bipolar disorder and find a correlation between some fragile s...

journal_title：Yonsei medical journal

authors： Demirhan O,Tastemir D,Sertdemir Y

更新日期：2009-02-28 00:00:00

abstract：:A porcine heart valve was irradiated by Ultraviolet (UV) rays (10 W, 254 nm) for 2, 4, 8 and 24 hours at 4 degrees C to cross-link the structural collagen matrix. The degree of cross-linking was evaluated by assaying the released amount of hydroxyproline (Hyp) from the matrix, and comparing it with the positive contro...

journal_title：Yonsei medical journal

authors： Suh H,Lee WK,Park JC,Cho BK

更新日期：1999-04-01 00:00:00

abstract：:This study was undertaken to evaluate the clinical usefulness of operative laparoscopy in treatment of benign ovarian cysts. A retrospective study was carried on 468 operative laparoscopy cases performed from September 1995 to September 1998 at Yonsei University College of Medicine, Department of Obstetrics and Gyneco...

journal_title：Yonsei medical journal

authors： Park KH,Chung JE,Kim JY,Lee BS

更新日期：1999-12-01 00:00:00