Abstract:
PURPOSE:Growing evidence suggests that hypoadiponectinemia may play a significant role in the development of metabolic syndrome (MetS). Therefore, the relationships between serum adiponectin with MetS and components of MetS were investigated in non-diabetic samples of drawn from the Koreans general population. MATERIALS AND METHODS:We performed a cross-sectional study in samples of older Koreans (age > 40 years) including 2,471 men and 3,463 women. MetS was defined according to the Asian modified criteria of the National Cholesterol Education Program Adult Treatment Panel III report. Serum adiponectin concentrations were measured by radioimmunoassay. RESULTS:The median adiponectin level in MetS was significantly lower than that in non-MetS subjects in men (6.00 vs. 8.00 μg/mL, p < 0.001) and women (10.12 vs. 11.74 μg/mL, p < 0.001). Adiponectin concentration was negatively correlated with waist circumference and levels of triglyceride, C-reactive protein (CRP), fasting glucose, and insulin, and positively correlated with high-density lipoprotein and age in both genders (p < 0.001). In a multivariate regression model after adjustment for age, body mass index, smoking, CRP, and lipid profiles, the odds ratio of MetS comparing extreme quartiles of adiponectin distribution was 0.32 [95% confidence interval (CI), 0.20 to 0.50] in men and 0.57 (95% CI, 0.43 to 0.76) in women. CONCLUSION:Adiponectin levels are independently associated with the phenotype of MetS, as well as components of MetS in the non-diabetic Korean general population.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Koh SB,Yoon J,Kim JY,Yoo BS,Lee SH,Park JK,Choe KHdoi
10.3349/ymj.2011.52.2.234subject
Has Abstractpub_date
2011-03-01 00:00:00pages
234-41issue
2eissn
0513-5796issn
1976-2437pii
201103234journal_volume
52pub_type
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