Abstract:
:This study was performed to investigate the effect of peritoneal glucose load on plasma leptin concentrations in the continuous ambulatory peritoneal dialysis (CAPD) performed on 13 non-diabetic ESRD patients. Plasma leptin and insulin concentrations were measured for 2 hours during a single 2 liter exchange of 1.5% glucose-based dialysate (SPD, n = 6), for 7 days of daily peritoneal dialysis (DPD, n = 7). In DPD, standard full volume (2,000 ml x 4 times/day) exchange was performed immediately after operation. In SPD, plasma leptin and insulin concentrations remained unchanged during the study. In DPD, the plasma leptin concentration increased significantly after CAPD on the first day (PD1) (11.2 +/- 5.4 to 17.0 +/- 6.0 ng/mL, p < 0.05) and this elevation seemed to persist until 7 days after operation. After CAPD, there was no significant day-to-day variation in peritoneal glucose absorption (391-465 cal). Oral intake seemed to decrease on operation day (PD0) and PD1 and then increased slowly. Plasma insulin and glucose concentrations did not significantly change after CAPD. Changes of leptin concentration were significantly correlated with the changes of peritoneal glucose absorption at PD1. In conclusion, continuous peritoneal glucose load may affect plasma leptin concentrations in CAPD patients.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Kim MJ,Kim GA,Lee SW,Song JH,Hyun IYdoi
10.3349/ymj.2000.41.4.485keywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
485-90issue
4eissn
0513-5796issn
1976-2437journal_volume
41pub_type
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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doi:10.3349/ymj.2003.44.1.150
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
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更新日期:2007-10-31 00:00:00
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更新日期:2014-03-01 00:00:00
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journal_title:Yonsei medical journal
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