The effects of Treponema pallidum on human dendritic cells.

Abstract:

:Cell mediated immune responses play a prominent role in syphilis, which is caused by Treponema pallidum. The role of dendritic cells (DC) in the syphilitic infection is not well understood in human. In the present study, we studied interaction of T. pallidum with DC, generated from human peripheral blood mononuclear cells with GM-CSF and IL-4. After adding T. pallidum for 16 hours to immature DC at culture day 7, the change of surface antigens on DC was monitored by flow cytometry, the amount of IL-12 in culture supernatant of DC was measured by ELISA and T cell stimulatory capacity of DC was checked in mixed lymphocyte reaction (MLR). We have observed an efficient phagocytosis of T. pallidum by electron microscopy as early as 2 hours after addition of T. pallidum to DC. Interaction of DC with T. pallidum resulted in increased surface expression of CD83 which was proportionally increased according to the number of T. pallidum. Expressions of CD80, CD86 and HLA-DR on DC were slightly increased. The amount of IL-12 in the culture supernatant of DC was increased (1,099 pg/ml) after the addition of T. pallidum. T. pallidum-infected DC also displayed enhanced T cell stimulatory capacity in MLR. As seen from the above, we observed phagocytosis of T. pallidum by DC as early as 2 hours after addition of T. pallidum to DC and found that T. pallidum can stimulate DC maturation which mean that DC modulate an protective immune response during T. pallidum infection.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Shin JL,Chung KY,Kang JM,Lee TH,Lee MG

doi

10.3349/ymj.2004.45.3.515

keywords:

subject

Has Abstract

pub_date

2004-06-30 00:00:00

pages

515-22

issue

3

eissn

0513-5796

issn

1976-2437

pii

200406515

journal_volume

45

pub_type

杂志文章
  • Association of the adiponectin gene variations with risk of ischemic stroke in a Korean population.

    abstract:PURPOSE:Stroke is the second leading cause of death and a major cause of morbidity and mortality worldwide. Evidence of variations in adiponectin (AdipoQ) genes that are associated with ischemic stroke has not been consistent, and it is unclear whether the same loci contribute to these associations in the Korean popula...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2011.52.1.20

    authors: Cheong MY,Bang OS,Cha MH,Park YK,Kim SH,Kim YJ

    更新日期:2011-01-01 00:00:00

  • Gene expression pattern of human chorion-derived mesenchymal stem cells during adipogenic differentiation.

    abstract:PURPOSE:The aim of this study was to identify the adipocyte-specific gene expression patterns in chorion-derived mesenchymal stem cells during adipogenic differentiation. MATERIALS AND METHODS:Chorionic cells were isolated from the third trimester chorions from human placenta at birth and identified morphologically an...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2012.53.5.1036

    authors: Kim YH,Park TC,Lee G,Shin JC

    更新日期:2012-09-01 00:00:00

  • A case of urethral replacement with polytetrafluoro-ethylene graft for multiple anterior urethral strictures.

    abstract::Recently, the authors had an opportunity to treat a 73-year-old male patient who was transferred to our institution with problematic multiple strictures of the anterior urethra subsequent to a suprapubic cystostomy. A proximal urethra was reconstructed with scrotal skin, but due to the shortage of distal skin, as a la...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1989.30.2.198

    authors: Choi HK,Chang SK

    更新日期:1989-01-01 00:00:00

  • Specially programmed respiratory muscle training for singers by using respiratory muscle training device (Ultrabreathe).

    abstract::Respiratory muscle training is one of the major methods for enhancing the vocal function. Singers who must use their voice most frequently are well aware of the importance of respiration. However, most of them do not know precisely how to exercise their abdominal respiration. Using a respiratory training device, singe...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2004.45.5.810

    authors: Nam DH,Lim JY,Ahn CM,Choi HS

    更新日期:2004-10-31 00:00:00

  • Effects of chronic aluminum administration on blood and liver iron-related parameters in mice.

    abstract::In this study, the effects of chronically administered aluminum on iron metabolism-related parameters of liver and blood of mice were investigated. An additional purpose to determine how chronic aluminum administration together with vitamin E as an antioxidant to mice changed the parameters related to iron metabolism....

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2004.45.1.135

    authors: Turgut G,Kaptanoğlu B,Turgut S,Enli Y,Genç O

    更新日期:2004-02-29 00:00:00

  • Treatment of Behçet's disease.

    abstract::Behçet's disease is characterized with multifactorial etiopathogenesis and multiclinical pictures. The treatment of patients with Behçet's disease is based on the severity of illness, and the most appropriate management of Behçet's disease requires a multidisciplinary approach. Although various therapeutic modalities ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.1997.38.6.401

    authors: Bang D

    更新日期:1997-12-01 00:00:00

  • RETT's syndrome in Korea--report of two cases.

    abstract::Rett's syndrome(RS) is a progressive neurodegenerative disorder characterized by exclusive occurrence in females, autistic behavior, dementia, gait ataxia, loss of purposeful use of the hands with stereotypic hand movement, and seizures. Initially RS was considered to be very rare; however, recent reports suggest that...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.1991.32.2.172

    authors: Choi YC,Lee BI,Huh K,Kim GW

    更新日期:1991-06-01 00:00:00

  • Network analysis of Korean health insurance policy-making process.

    abstract::This study examines how the decision-making process evolved in Korea during the initial phases of introduction and implementation of National Health Insurance. This study analyses the official documents and interviews views made with government officials and related personnel. We used the method of network analysis an...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1992.33.2.121

    authors: Sohn M,Yu SH,Kim YH

    更新日期:1992-06-01 00:00:00

  • Hypoxia Induces Epithelial-Mesenchymal Transition in Follicular Thyroid Cancer: Involvement of Regulation of Twist by Hypoxia Inducible Factor-1α.

    abstract:PURPOSE:Although follicular thyroid cancer (FTC) has a relatively fair prognosis, distant metastasis sometimes results in poor prognosis and survival. There is little understanding of the mechanisms contributing to the aggressiveness potential of thyroid cancer. We showed that hypoxia inducible factor-1α (HIF-1α) induc...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2015.56.6.1503

    authors: Yang YJ,Na HJ,Suh MJ,Ban MJ,Byeon HK,Kim WS,Kim JW,Choi EC,Kwon HJ,Chang JW,Koh YW

    更新日期:2015-11-01 00:00:00

  • Cytological results of ultrasound-guided fine-needle aspiration cytology for thyroid nodules: emphasis on correlation with sonographic findings.

    abstract:PURPOSE:To compare the cytological results of ultrasound-guided fine-needle aspiration (US-FNA) cytology of thyroid nodules to sonographic findings and determine whether US findings are helpful in the interpretation of cytological results. MATERIALS AND METHODS:Among the thyroid nodules that underwent US-FNA cytology,...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2011.52.5.838

    authors: Lee MJ,Hong SW,Chung WY,Kwak JY,Kim MJ,Kim EK

    更新日期:2011-09-01 00:00:00

  • Interaction between warfarin and the herbal product Shengmai-yin: a case report of intracerebral hematoma.

    abstract::A 71-year-old man was stable on warfarin (2.25 mg daily) therapy with an international normalized ratio (INR) of 1.8-2.2 after a heart valve replacement surgery. Recently, he consumed the liquid-like herbal product called shengmai-yin (10 mL daily) against medical advice. Seven days after the daily consumption of shen...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2010.51.5.793

    authors: Su Q,Li Y

    更新日期:2010-09-01 00:00:00

  • A case of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug.

    abstract::Isotretinoin is a known human teratogen that can cause multiple malformations. At present, women who conceive one cycle after discontinuing isotretinoin are told that their teratogenic risk is not higher than baseline. We present a case of both-ear malformation in a newborn whose mother had taken isotretinoin for 2 ye...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2009.50.3.445

    authors: Lee SM,Kim HM,Lee JS,Yoon CS,Park MS,Park KI,Namgung R,Lee C

    更新日期:2009-06-30 00:00:00

  • Pharmacokinetic modeling of phagocytic activity of the liver using superparamagnetic iron oxide nanoparticles in dynamic MR imaging.

    abstract::The purpose of this study was to determine whether phagocytic activity is measurable by dynamic superparamagnetic iron oxide-enhanced MR imaging. For these experiments on New Zealand White rabbits, which were randomly allocated to normal and silica treated groups, we performed a dynamic MR study and radioisotope study...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.3.429

    authors: Na JB,Suh JS,Huh YM,Kim SJ,Kim SH,Cha SH,Lee SH

    更新日期:2003-06-30 00:00:00

  • Changes in treatment outcomes of gastric cancer surgery over 45 years at a single institution.

    abstract:PURPOSE:Although many studies have demonstrated improvements in short-and long-term outcomes of gastric cancer surgery, changes in long-term survival over time are not well-established. This study was conducted to evaluate changes in host, tumor, and treatment factors in patients treated at a single institution over a ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2008.49.3.409

    authors: Hyung WJ,Kim SS,Choi WH,Cheong JH,Choi SH,Kim CB,Noh SH

    更新日期:2008-06-30 00:00:00

  • Change in Renal Function among HIV-Infected Koreans Receiving Tenofovir Disoproxil Fumarate-Backbone Antiretroviral Therapy: A 3-Year Follow-Up Study.

    abstract:PURPOSE:Tenofovir disoproxil fumarate (TDF) is commonly prescribed as a fixed-dose, co-formulated antiretroviral drug for HIV-1 infection. The major concern of long-term TDF use is renal dysfunction. However, little is known about the long-term patterns of changes in renal function in HIV-infected Koreans receiving TDF...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2017.58.4.770

    authors: Lee KH,Lee JU,Ku NS,Jeong SJ,Han SH,Choi JY,Song YG,Kim JM

    更新日期:2017-07-01 00:00:00

  • Kidney function in living donors undergoing nephrectomy by sevoflurane or desflurane anesthesia.

    abstract:PURPOSE:Although there is no clinical evidence of nephrotoxicity with the volatile anesthetics currently used in general anesthesia, a better agent should be needed in terms of preserving postoperative renal function in living kidney donors who have only single remaining kidney. The purpose of the current retrospective...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2013.54.5.1266

    authors: Kim MS,Lee JR,Kim MS,Ham SY,Choi SH

    更新日期:2013-09-01 00:00:00

  • Extranodal marginal zone lymphoma occurring along the trachea and central airway.

    abstract::Extranodal marginal zone lymphoma is a low-grade B cell lymphoma that presents with an indolent clinicopathologic nature. Although this tumor can occur in various sites, including the gastrointestinal tract and lungs, it develops and spreads extremely rarely along the trachea and central airway. We report a case of ex...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2008.49.5.860

    authors: Kang JY,Park HJ,Lee KY,Lee SY,Kim SJ,Park SH,Kim YK

    更新日期:2008-10-31 00:00:00

  • CT and MR findings of primary cardiac lymphoma: report upon 2 cases and review.

    abstract::Although primary cardiac lymphoma was a near fatal disease in the past, recent advances in imaging diagnosis and chemotherapy have dramatically improved survival. We describe the CT and MR findings of primary cardiac lymphoma in two immunocompetent subjects who recovered after chemotherapy. The primary cardiac lymphom...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2001.42.4.451

    authors: Ryu SJ,Choi BW,Choe KO

    更新日期:2001-08-01 00:00:00

  • Surgical outcome of synchronous second primary cancer in patients with gastric cancer.

    abstract:PURPOSE:In order to improve the likelihood of curative and safe gastric surgery, this study investigated the clinical features and surgical outcomes of gastric cancer with a synchronous cancer. PATIENTS AND METHODS:The clinicopathological data of 10,090 gastric cancer patients at Samsung Medical Center from September ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2007.48.6.981

    authors: Ha TK,An JY,Youn HG,Noh JH,Sohn TS,Kim S

    更新日期:2007-12-31 00:00:00

  • Correlation between EGFR and c-erbB-2 oncoprotein status and response to neoadjuvant chemotherapy in cervical carcinoma.

    abstract::Neoadjuvant chemotherapy prior to definitive radical surgery or radiotherapy may be effective in reducing tumor volume or clinical stage and may even enhance pelvic control and survival. However, there are significant limitations to the use of neoadjuvant therapy in the non-responder group. They include delayed total ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1999.40.3.207

    authors: Kim JW,Kim YT,Kim DK

    更新日期:1999-06-01 00:00:00

  • The prevalence study on restriction fragment length polymorphism analysis for the detection of hemophilia A carrier.

    abstract::We have analyzed two (BclI and XbaI) intragenic restriction fragment length polymorphisms (RFLPs) and St14 (DXS52) variable number of tandem repeats (VNTR) by rapid PCR method in 97 unrelated normal subjects. The incidences for positive Bc1I and XbaI polymorphic sites in the Koreans were 81% and 72%, respectively, whi...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1993.34.3.239

    authors: Song KS,Lee CH,Chung CS,Lee K,Yang YH,Kim KY

    更新日期:1993-09-01 00:00:00

  • Associations for BCO2, PCSK9, and TR1B1 Polymorphism and Lifestyle Factors with Ischemic Stroke: A Nested Case-Control Study.

    abstract:PURPOSE:To investigate associations for polymorphisms in β-carotene 9',10'-oxygenase (BCO2, rs10431036 and rs11214109), proprotein convertase subtilisin kexin type 9 (PCSK9, rs11583680), and tribbles pseudokinase 1 (TRIB1, rs17321515 and rs2954029), as well as lifestyle factors, with ischemic stroke (IS). MATERIALS AN...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2019.60.7.659

    authors: Zhao TY,Li Z,Lei S,Huang L,Yang L

    更新日期:2019-07-01 00:00:00

  • Herpes simplex virus 2 infection rate and necessity of screening during pregnancy: a clinical and seroepidemiologic study.

    abstract:PURPOSE:This study determined the seroprevalence of herpes virus 2 in gravidas and the differences between herpes virus 2-infected and healthy gravidas. The need to screen gravidas for herpes virus 2 was also evaluated. MATERIALS AND METHODS:A retrospective analysis involving 500 gravidas who underwent herpes virus 2 ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2012.53.2.401

    authors: Kim ID,Chang HS,Hwang KJ

    更新日期:2012-03-01 00:00:00

  • A Rare Case of Intra-Endometrial Leiomyoma of Uterus Simulating Degenerated Submucosal Leiomyoma Accompanied by a Large Sertoli-Leydig Cell Tumor.

    abstract::A 50-year-old peri-menopausal woman presented with hard palpable mass on her lower abdomen and anemia from heavy menstrual bleeding. Ultrasonography showed a 13×12 cm sized hypoechoic solid mass in pelvis and a 2.5×2 cm hypoechoic cystic mass in uterine endometrium. Abdomino-pelvic computed tomography revealed a hypod...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2016.57.2.523

    authors: Jeong K,Lee SR,Park S

    更新日期:2016-03-01 00:00:00

  • Hydrogen peroxide as an effective disinfectant for Pasteurella multocida.

    abstract::Pasteurella multocida (P. multocida) infections vary widely, from local infections resulting from animal bites and scratches to general infections. As of yet, no vaccine against P. multocida has been developed, and the most effective way to prevent pathogenic transmission is to clean the host environment using disinfe...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,收录出版

    doi:10.3349/ymj.2014.55.4.1152

    authors: Jung IS,Kim HJ,Jung WY,Kim CW

    更新日期:2014-07-01 00:00:00

  • MicroRNA-98-5p Inhibits Tumorigenesis of Hepatitis B Virus-Related Hepatocellular Carcinoma by Targeting NF-κB-Inducing Kinase.

    abstract:PURPOSE:MicroRNAs play key regulatory roles in the tumorigenesis of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). This study aimed to explore the regulatory effects of microRNA-98-5p (miR-98-5p) on the proliferation, migration, invasion, and apoptosis of HBV-HCC cells, as well as the underlying mechanis...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2020.61.6.460

    authors: Fei X,Zhang P,Pan Y,Liu Y

    更新日期:2020-06-01 00:00:00

  • A Single-Center, Retrospective Study of Bevacizumab-Containing Neoadjuvant Chemotherapy followed by Interval Debulking Surgery for Ovarian Cancer.

    abstract:PURPOSE:We evaluated whether adding bevacizumab to current platinum-based chemotherapy could improve clinical outcomes without affecting safety. MATERIALS AND METHODS:We retrospectively reviewed medical records of patients with pathologically confirmed ovarian cancer who received neoadjuvant chemotherapy (NAC) at Yons...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2020.61.4.284

    authors: Park J,Eoh KJ,Nam EJ,Kim S,Kim SW,Kim YT,Lee JY

    更新日期:2020-04-01 00:00:00

  • Multiple small intestinal stromal tumors associated with neurofibromatosis-1.

    abstract::Gastrointestinal stromal tumors (GISTs) are rarely noted in association with neurofibromatosis-1 (NF-1, von Recklinghausen disease) as an individual gastrointestinal manifestation. We report here a case of multiple GISTs with an abundant skeinoid fiber in the jejunum of a 43-year-old woman diagnosed as NF-1. Histologi...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2004.45.3.564

    authors: Joo M,Lee HK,Kim H,Kim MK,Chi JG

    更新日期:2004-06-30 00:00:00

  • Use of grafts in pelvic reconstructive surgery.

    abstract::There has been growing interest in the use of grafts in pelvic reconstructive surgery. This article will address available graft materials and assess their clinical efficacy and safety. We conducted a Pubmed MEDLINE literature search for full-length English text studies with follow-up periods of at least one year. The...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2007.48.2.147

    authors: Jeon MJ,Bai SW

    更新日期:2007-04-30 00:00:00

  • Squamous cell carcinoma of the cornea.

    abstract::In this paper, a case of corneal squamous cell carcinoma is reported. Invasive squamous cell carcinoma of the cornea is a rare disorder and has not been previously described in the Korean literature. In this case, the invasive squamous cell carcinoma of the cornea was treated by complete excision and cryotherapy. No e...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2001.42.5.576

    authors: Shin HJ,Sohn JH,Goo YS,Park JY,Choi CH,Kim EK,Cho SH,Yoo NC,Roh JK

    更新日期:2001-10-01 00:00:00