Abstract:
PURPOSE:To investigate associations for polymorphisms in β-carotene 9',10'-oxygenase (BCO2, rs10431036 and rs11214109), proprotein convertase subtilisin kexin type 9 (PCSK9, rs11583680), and tribbles pseudokinase 1 (TRIB1, rs17321515 and rs2954029), as well as lifestyle factors, with ischemic stroke (IS). MATERIALS AND METHODS:This nested case-control study included 161 patients with IS and 483 matched control individuals. We collected medical reports, lifestyle details, and blood samples from individuals and used the PCR-ligase detection reaction method to genotype single nucleotide polymorphisms (SNPs). RESULTS:The GA+AA genotype of rs10431036 (p<0.001) and rs17321515 (p=0.003), the CT+TT genotype of rs11214109 (p=0.005), and the TA+AA genotype of rs2954029 (p=0.006) in dominant models increased the risk of IS. In additive models, the GG genotype of rs17321515 (p=0.005) and the TT genotype of rs2954029 (p=0.008) increased the risk of IS. Adequate intake of fruits/vegetables reduced the risk of IS (p=0.005). Although there was no interaction between genes and fruits/vegetables, people with inadequate intake of fruits/vegetables who carried a risk genotype had a higher risk of IS than those only having inadequate fruits/vegetables intake or those only carrying a risk genotype. Also, the haplotypes AC, AT, and GT (comprising rs10431036 and rs11214109) and GT (comprising rs2954029 and rs17321515) were found to be associated with an increased risk of IS (p<0.05). CONCLUSION:Polymorphisms in BCO2 and TRIB1 and fruits/vegetables intake were associated with IS. These results provide the theoretical basis for gene screening to prevent chronic cerebrovascular diseases.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Zhao TY,Li Z,Lei S,Huang L,Yang Ldoi
10.3349/ymj.2019.60.7.659subject
Has Abstractpub_date
2019-07-01 00:00:00pages
659-666issue
7eissn
0513-5796issn
1976-2437pii
60.659journal_volume
60pub_type
杂志文章abstract::Ankle spasticity following brain injury leads to abnormal posture and joint contracture; making standing or walking impossible. This study investigates the efficacy of selective tibial neurotomy (STN) and intensive rehabilitation in a patient who suffered ankle spasticity after brain injury. This case describes a 37-y...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2004.45.4.743
更新日期:2004-08-31 00:00:00
abstract::Although pectoralis major plays an important role as a prime or assistant mover for the varied range of shoulder movement, there was no significant functional loss in ordinary activities in case of congenital absence of this muscle, because of compensation of surrounding muscles. This report describes a 22-year-old so...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1991.32.1.87
更新日期:1991-03-01 00:00:00
abstract::Primary adrenal lymphoma (PAL) is a very rare disease and usually does not have disease elsewhere, and if present, it is frequently extranodal. Several cases of PALs, with central nervous system (CNS) involvement, gastrointestinal tract or other endocrine organs involvement, have been reported in Western literature. W...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2002.43.3.385
更新日期:2002-06-01 00:00:00
abstract::Fractures of the distal radius are common among elderly patients. Although the indications for surgical treatment are clearly defined, there are patients who will not consent to an operation, even when it is indicated. Inevitably, these cases will require conservative treatment. The aim of this study was to determine ...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2003.44.5.836
更新日期:2003-10-30 00:00:00
abstract:PURPOSE:During stimulated in vitro fertilization (IVF) cycle, up to 30% of the recovered oocytes are immature ones which have poor fertilization capacity; however, the precise influencing factors are largely unknown. Here, we analyzed the association of oocyte immaturity with woman's age in IVF cycles stimulated by sin...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2012.53.1.181
更新日期:2012-01-01 00:00:00
abstract::Behçet's disease is a chronic relapsing multisystemic inflammatory disorder characterized by four major symptoms (oral aphthous ulcers, genital ulcers, skin lesions, and ocular lesions) and occasionally by five minor symptoms (arthritis, gastrointestinal ulcers, epididymitis, vascular lesions, and central nervous syst...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2012.53.1.35
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:The proposed the thoracolumbar injury classification system (TLICS) for thoracolumbar injury cites the integrity of the posterior ligamentous complex (PLC). However, no report has elucidated the severity of damage in thoracic and lumbar injury with classification schemes by presence of the PLC injury. The purpo...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2013.54.4.1020
更新日期:2013-07-01 00:00:00
abstract::The purpose of this study was to determine whether phagocytic activity is measurable by dynamic superparamagnetic iron oxide-enhanced MR imaging. For these experiments on New Zealand White rabbits, which were randomly allocated to normal and silica treated groups, we performed a dynamic MR study and radioisotope study...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2003.44.3.429
更新日期:2003-06-30 00:00:00
abstract::Diffusion tensor imaging (DTI) allows to isolate the corticospinal tract (CST) area from adjacent structures. Using DTI, we investigated the characteristics of the CST areas according to the pontine level in the normal human brain. We recruited 33 healthy subjects and DTIs were acquired using a sensitivity-encoding he...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2013.54.3.785
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:Descent of the uterus is a major etiology of uterine prolapse. However, true cervical elongation can cause uterine prolapse without uterine descent. The aim of study was to investigate the clinical outcomes of Manchester operation in patients with uterine prolapse caused by "true cervical elongation," compared ...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2019.60.11.1074
更新日期:2019-11-01 00:00:00
abstract::Expression of estrogen receptors (ER)-alpha and -beta, as well as androgen receptor (AR), in hepatocellular carcinoma (HCC) is thought to be correlated with prognosis, survival, and male prevalence of HCC. These hypotheses are based on investigations of European patients; however the expression patterns of these recep...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2006.47.6.811
更新日期:2006-12-31 00:00:00
abstract:PURPOSE:Alpha-fetoprotein (AFP) is a prognostic marker for hepatocellular carcinoma (HCC). We investigated the prognostic value of AFP levels in patients who achieved complete response (CR) to transarterial chemoembolization (TACE) for HCC. MATERIALS AND METHODS:Between 2005 and 2018, 890 patients with HCC who achieve...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2021.62.1.12
更新日期:2021-01-01 00:00:00
abstract::We evaluated and compared procedural memory and auditory P300 event-related potential in age-matched normal controls (n = 15) and drug-naive patients with Parkinson's disease (n = 16). We used Gollin's incomplete picture test for visual procedural memory function and Tower of Hanoi puzzle for visuomotor procedural mem...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1995.36.4.367
更新日期:1995-09-01 00:00:00
abstract:PURPOSE:To analyze the feasibility of unilateral and bilateral translaminar screw placement in Koran population, and compare the acceptance rate using previously reported data in American population. MATERIALS AND METHODS:The translaminar lengths, thickness, heights, and sagittal-diagonal measurements were performed. ...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2015.56.1.159
更新日期:2015-01-01 00:00:00
abstract::The infusion and persistence in a transplant recipient of donor-derived bone marrow cells (DBMC) of multi-lineage can lead to a state of permanent chimerism. In solid vascular organ transplantation, the donor bone marrow lineage cells can even be derived from the transplant organ, and these cells can be detected in ve...
journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
doi:10.3349/ymj.2004.45.6.998
更新日期:2004-12-31 00:00:00
abstract::Dieulafoy's lesion is an uncommon cause of gastrointestinal bleeding. Hemorrhage occurs through mucosal erosion from an abnormally dilated submucosal artery. Although Dieulafoy's lesion is usually located in the stomach, it may occur anywhere in the gastrointestinal tract. We report here on a case of jejunal Dieulafoy...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2005.46.3.445
更新日期:2005-06-30 00:00:00
abstract:PURPOSE:Plasma levels of renin, angiotensin II and aldosterone are increased during normal pregnancy. However, these values in preeclampsia are decreased to nearly that of a nonpregnant subject, and vascular sensitivity to angiotensin II is increased. In preeclampsia, aldosterone is decreased less than rennin. Therefor...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2008.49.1.138
更新日期:2008-02-29 00:00:00
abstract:PURPOSE:To evaluate the clinicopathological characteristics and prognosis of localized resectable genitourinary sarcomas in adults. MATERIALS AND METHODS:Between September, 1996 and November, 2008, 18 consecutive cases of adults (12 men and 6 women; median age 48.8 years) who were treated for primary genitourinary sar...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2011.52.5.761
更新日期:2011-09-01 00:00:00
abstract::Pyogenic sacroiliitis is a relatively rare condition that often leads to surgical treatment, including debridement and arthrodesis. Here we introduce a new surgical technique using bilateral dual iliac screws to secure early ambulation and maximal fusion success rate for the treatment of pyogenic sacroiliitis. We retr...
journal_title:Yonsei medical journal
pub_type:
doi:10.3349/ymj.2020.61.2.198
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:Exclusive enteral nutrition (EEN) therapy effectively induces clinical remission in Crohn's disease (CD). It remains unclear, however, whether partial enteral nutrition (PEN) can maintain remission. This study was performed to determine the abilities of oral EEN and oral PEN to induce and maintain clinical remi...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2016.57.5.1185
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Patients with chronic kidney disease frequently show cognitive dysfunction. The association of depression and cognitive function is not well known in maintenance dialysis patients. We evaluated cognitive impairment and depression, as well as their relationship in regards to methods of dialysis, maintenance hemo...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2013.54.6.1447
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:To investigate the relationship between prostate volume and the increased risk for being diagnosed with prostate cancer (PCa) in men with slowly increasing prostate specific antigen (PSA). MATERIALS AND METHODS:A cohort of 1035 men who visited our hospital's health promotion center and were checked for serum P...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2013.54.5.1202
更新日期:2013-09-01 00:00:00
abstract::Recent studies have been reported the roles of the estrogen receptor (ER), progesterone receptor (PR) and p53 in the development of a pelvic organ prolapse (POP). The pathogenesis of stress urinary incontinence (SUI) is related to that of POP in the weakness of pelvic support. Therefore, this study was carried out to ...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2004.45.5.885
更新日期:2004-10-31 00:00:00
abstract::Left atrial appendage (LAA) occlusion can be employed as an alternative treatment to oral anticoagulation in patients with atrial fibrillation to prevent embolic events. Atrial septal defect (ASD) may be related with right heart dysfunction and allow paradoxical embolism to occur. However, occlusion of both LAA throug...
journal_title:Yonsei medical journal
pub_type:
doi:10.3349/ymj.2017.58.6.1237
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:Augmentation rhinoplasty using alloplastic materials is a relatively common procedure among Asians. Silicon, expanded polytetrafluoroethylene (Gore-tex®), and porous high density polyethylene (Medpor®) are most frequently used materials. This study was conducted to analyze revisional rhinoplasty cases with allo...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2014.55.6.1617
更新日期:2014-11-01 00:00:00
abstract::Effects of a platelet-released, naturally occurring nucleotide, adenosine 5'-tetraphosphate (ATPP) on vascular tone were analyzed in the isolated rat aorta. Under resting tension ATPP (1 approximately 100 microM) elicited concentration-dependent contractions in endothelium-intact aortic rings in contrast to the concen...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1995.36.6.487
更新日期:1995-12-01 00:00:00
abstract:PURPOSE:Magnetocardiography (MCG) has been proposed as a noninvasive, diagnostic tool for risk-stratifying patients with acute myocardial infarction (AMI). This study evaluated whether MCG predicts long-term prognosis in AMI. MATERIALS AND METHODS:In 124 AMI patients (95 males, mean age 60±11 years), including 39 with...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2016.57.6.1339
更新日期:2016-11-01 00:00:00
abstract::Antimicrobial resistance surveillance is necessary to determine the size of the problem and to guide empirical selection of antimicrobial agents for treating infected patients. The aim of this study was to analyze the results of susceptibility tests performed by hospitals participating in the Korean Nationwide Surveil...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2003.44.4.571
更新日期:2003-08-30 00:00:00
abstract::Since the Gordius worm is a parasite of crickets and several arthropods, cases of humans infected with this worm have been rare and accidental. A Gordius worm was obtained from a three-year-old girl who consulted a local clinic in Gwangju, Kyunggi-do, Korea. She lived in a rural area, and had eaten an insect that look...
journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
doi:10.3349/ymj.2003.44.3.557
更新日期:2003-06-30 00:00:00
abstract::The purpose of this study was to determine factors that could predict the one-year response of the lumbar bone mineral density (BMD) to alendronate treatment in elderly Japanese women with osteoporosis. Eighty-five postmenopausal women with osteoporosis, all of whom were between 55-88 years of age, were treated with a...
journal_title:Yonsei medical journal
pub_type: 临床试验,杂志文章
doi:10.3349/ymj.2004.45.4.676
更新日期:2004-08-31 00:00:00