Abstract:
:A 71-year-old man was stable on warfarin (2.25 mg daily) therapy with an international normalized ratio (INR) of 1.8-2.2 after a heart valve replacement surgery. Recently, he consumed the liquid-like herbal product called shengmai-yin (10 mL daily) against medical advice. Seven days after the daily consumption of shengmai-yin, he was admitted to the intensive care unit because of consciousness disturbance [Glasgow Coma Scale (GCS) score 7] with an INR of 5.08. Head computed topography revealed intracerebral hematoma in the left temporoparietal region. Both warfarin therapy and the herbal product were withdrawn. At the same time, therapy with intravenous vitamin K1 40 mg was started. On the second day of admission, craniectomy was performed to remove the intacerebral hematoma under general anesthesia. He remained confused and restless for 2 days, but then showed progressive recovery in the consciousness level as well as motor and verbal functions. Shengmai-yin contains herbal ingredients that can interact with warfarin. The Drug Interaction Probability Scale (DIPS) indicated that warfarin and shengmai-yin were highly probable causes of intracerebral hematoma. Patients on warfarin therapy should be discouraged from taking herbal medicines, especially preparations that are already known to have antiplatelet and antithrombotic effects.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Su Q,Li Ydoi
10.3349/ymj.2010.51.5.793subject
Has Abstractpub_date
2010-09-01 00:00:00pages
793-6issue
5eissn
0513-5796issn
1976-2437pii
201009796journal_volume
51pub_type
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2013.54.4.875
更新日期:2013-07-01 00:00:00
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journal_title:Yonsei medical journal
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更新日期:2015-01-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1992.33.2.121
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journal_title:Yonsei medical journal
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更新日期:2003-10-30 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1996.37.4.290
更新日期:1996-08-01 00:00:00
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journal_title:Yonsei medical journal
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abstract::Klinefelter's syndrome is one of the most common forms of primary hypogonadism and infertility in males. It is characterized by small and firm testes, gynecomastia, azoospermia, and an elevated gonadotropin level. The frequencies of diabetes mellitus, breast cancer, and germ cell neoplasia increases in Klinefelter's s...
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doi:10.3349/ymj.2004.45.2.341
更新日期:2004-04-30 00:00:00
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pub_type: 杂志文章
doi:10.3349/ymj.2006.47.5.667
更新日期:2006-10-31 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1994.35.2.223
更新日期:1994-06-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2002.43.1.37
更新日期:2002-02-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2011.52.3.535
更新日期:2011-05-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1991.32.3.215
更新日期:1991-09-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1995.36.3.287
更新日期:1995-07-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1993.34.1.35
更新日期:1993-03-01 00:00:00
abstract::Although pectoralis major plays an important role as a prime or assistant mover for the varied range of shoulder movement, there was no significant functional loss in ordinary activities in case of congenital absence of this muscle, because of compensation of surrounding muscles. This report describes a 22-year-old so...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1991.32.1.87
更新日期:1991-03-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章,收录出版,评审
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更新日期:2006-02-28 00:00:00
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journal_title:Yonsei medical journal
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doi:10.3349/ymj.2011.52.1.20
更新日期:2011-01-01 00:00:00
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journal_title:Yonsei medical journal
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doi:10.3349/ymj.1998.39.5.417
更新日期:1998-10-01 00:00:00
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更新日期:1993-09-01 00:00:00
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journal_title:Yonsei medical journal
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更新日期:2007-02-28 00:00:00
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更新日期:2003-06-30 00:00:00
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pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 已发布勘误
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更新日期:2017-09-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2006-08-31 00:00:00
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更新日期:2012-09-01 00:00:00
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更新日期:2002-06-01 00:00:00
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pub_type: 杂志文章
doi:10.3349/ymj.2008.49.1.58
更新日期:2008-02-29 00:00:00