Abstract:
PURPOSE:A high risk of cardiovascular disease (CVD) is reported for HIV-infected individuals. While a link between abacavir and CVD risk is suggested, an association between abacavir and hypertension remains unclear. This study evaluated hypertension risk with abacavir use in comparison to non-abacavir antiretroviral treatment (ART). MATERIALS AND METHODS:From a nationwide cohort of HIV-infected individuals on their initial ART, 6493 who were free of hypertension at baseline were analyzed. The use of ART was treated as a time-varying covariate measured as a daily unit. Incidence rate of hypertension was calculated, and Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) with 95% confidence interval (CI) of incident hypertension overall and among subgroups. RESULTS:From the 6493 participants, 24072 person-years (PY) of follow-up were contributed during 2008-2016. The incidence rates of hypertension were 4.6 and 3.6 per 100 PY for abacavir and non-abacavir ART users, respectively. The population attributable fraction of abacavir use on hypertension was 12%. Abacavir exposure did not elevate the risk of hypertension among overall study population [HR, 1.2 (95% CI, 1.0-1.4), p=0.061]. However, those with poor ART adherence, defined as a medication possession ratio <50% [HR, 1.9 (95% CI, 1.5-2.4), p<0.0001] or requiring prophylactic antibiotics [HR, 1.2 (95% CI, 1.0-1.3), p=0.023], were at risk of hypertension induced by abacavir, as were men, individuals aged ≥40 years, and patients visiting tertiary hospitals in urban areas. CONCLUSION:When present, poor ART adherence, requiring prophylactic antibiotics, male sex, and older age may warrant additional concern for hypertension in patients treated with abacavir.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Kim J,Bang JH,Shin JY,Yang BR,Lee J,Park BJdoi
10.3349/ymj.2018.59.10.1245subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1245-1252issue
10eissn
0513-5796issn
1976-2437pii
59.1245journal_volume
59pub_type
杂志文章abstract::The human major histocompatibility complex HLA is located on the short arm of chromosome 6. It is known to be the most polymorphic genetic system in humans. The biological role of the HLA class I and class II molecules is to present processed peptide antigens. The HLA system is clinically important as transplantation ...
journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
doi:10.3349/ymj.2007.48.1.11
更新日期:2007-02-28 00:00:00
abstract::Left atrial appendage (LAA) occlusion can be employed as an alternative treatment to oral anticoagulation in patients with atrial fibrillation to prevent embolic events. Atrial septal defect (ASD) may be related with right heart dysfunction and allow paradoxical embolism to occur. However, occlusion of both LAA throug...
journal_title:Yonsei medical journal
pub_type:
doi:10.3349/ymj.2017.58.6.1237
更新日期:2017-11-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
doi:10.3349/ymj.2009.50.3.309
更新日期:2009-06-30 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2003.44.2.347
更新日期:2003-04-30 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2017.58.1.90
更新日期:2017-01-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2010.51.4.546
更新日期:2010-07-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2013.54.4.1020
更新日期:2013-07-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2013.54.3.715
更新日期:2013-05-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1999.40.5.478
更新日期:1999-10-01 00:00:00
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journal_title:Yonsei medical journal
pub_type:
doi:10.3349/ymj.2018.59.3.457
更新日期:2018-05-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1995.36.4.367
更新日期:1995-09-01 00:00:00
abstract::Four cases of hepatocellular carcinoma (HCC) were surgically resected following combined radiotherapy (RT) and hyperthermia (HT). Complete necrosis of the tumor without viable tumor cell was found in one case and extensive tumor necrosis was observed in the other three cases; the percentage of necrosis in the specimen...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1991.32.2.147
更新日期:1991-06-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章,meta分析
doi:10.3349/ymj.2016.57.5.1260
更新日期:2016-09-01 00:00:00
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journal_title:Yonsei medical journal
pub_type:
doi:10.3349/ymj.2017.58.2.458
更新日期:2017-03-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2012.53.2.328
更新日期:2012-03-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
doi:10.3349/ymj.2020.61.3.201
更新日期:2020-03-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2017.58.2.388
更新日期:2017-03-01 00:00:00
abstract::Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscular disorder characterized by weakness of facial, shoulder, abdominal, hip girdle, humeral, and anterior distal leg muscles, with descending progression from the face to the legs in an asymmetric pattern. In about 5% of patients with FSHD, no ...
journal_title:Yonsei medical journal
pub_type:
doi:10.3349/ymj.2021.62.1.95
更新日期:2021-01-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 临床试验,杂志文章
doi:10.3349/ymj.2005.46.1.86
更新日期:2005-02-28 00:00:00
abstract::Coronary-subclavian steal through the left internal mammary graft is a rare cause of myocardial ischemia in patients who have had a coronary bypass surgery. We report a 70-year-old man who presented with sustained monomorphic ventricular tachycardia 5 years after the surgical creation of a left internal mammary to the...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2009.50.6.852
更新日期:2009-12-31 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章,随机对照试验
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更新日期:2017-05-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2015.56.2.348
更新日期:2015-03-01 00:00:00
abstract::Presently, allergy diagnosis and therapy procedures are undergoing a transition phase in which allergen extracts are being step-by-step replaced by molecule-based products. The new developments will allow clinicians to obtain detailed information on sensitization patterns, more accurate interpretation of allergic symp...
journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
doi:10.3349/ymj.2014.55.4.839
更新日期:2014-07-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
doi:10.3349/ymj.1998.39.6.611
更新日期:1998-12-01 00:00:00
abstract::When cells are exposed to a low dose of a mutagenic or clastogenic agent, they often become less sensitive to the effects of a higher dose administered subsequently. Such adaptive responses were first described in Escherichia coli. Studies on mammalian cells have been limited to human lymphocytes exposed to low doses ...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1994.35.1.77
更新日期:1994-03-01 00:00:00
abstract:PURPOSE:Adipogenic differentiation of adipose tissue-derived mesenchymal stem cells (AMSCs) is critical to many disease-related disorders, such as obesity and diabetes. Studies have demonstrated that miRNA-138 (miR-138) is closely involved in adipogenesis. However, the mechanisms affected by miR-138 remain unclear. Thi...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2019.60.12.1187
更新日期:2019-12-01 00:00:00
abstract::Although nitric oxide (NO) plays an important role in the pathophysiological process of cerebral ischemia or severe traumatic brain injury, its contribution to the pathogenesis of moderate diffuse axonal injury (mDAI) remains to be clarified. The alterations in nitric oxide synthase (NOS) activity and the histopatholo...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2001.42.5.518
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:Wnt and mammalian target of rapamycin (mTOR) are major molecular signaling pathways associated with the development and progression of tumor, as well as the maintenance and proliferation of cancer stem cells (CSCs), in colorectal cancer (CRC). Identifying patients at risk of poor prognosis is important to deter...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2020.61.7.572
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:To evaluate the diagnosis and treatment of the carpal tunnel syndrome (CTS) due to space occupying lesions (SOL). MATERIALS AND METHODS:Eleven patients and 12 cases that underwent surgery for CTS due to SOL were studied retrospectively. We excluded SOL caused by bony lesions, such as malunion of distal radius ...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2009.50.2.257
更新日期:2009-04-30 00:00:00
abstract::We report herein successful rigid bronchoscopy with preserved spontaneous breathing of a 54-day-old infant with tracheal web associated with previous ventricular septal defect (VSD) repair. We considered the use of dexmedetomidine in conjunction with intermittent ketamine from the following three clinical aspects. Fir...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2014.55.2.539
更新日期:2014-03-01 00:00:00