Abstract:
PURPOSE:To overcome the potential disadvantages of the use of foreign materials and autologous fat or collagen, we introduce here an autologous plasma gel for injection laryngoplasty. The purpose of this study was to present a new injection material, a plasma gel, and to discuss its clinical effectiveness. MATERIALS AND METHODS:From 2 mL of blood, the platelet poor serum layer was collected and heated at 100°C for 12 min to form a plasma gel. The plasma gel was then injected into a targeted site; the safety and efficacy thereof were evaluated in 30 rats. We also conducted a phase I/II clinical study of plasma gel injection laryngoplasty in 11 unilateral vocal fold paralysis patients. RESULTS:The plasma gel was semi-solid and an easily injectable material. Of note, plasma gel maintains the same consistency for up to 1 year in a sealed bottle. However, exposure to room air causes the plasma gel to disappear within 1 month. In our animal study, the autologous plasma gel remained in situ for 6 months in animals with minimal inflammation. Clinical study showed that vocal cord palsy was well compensated for with the plasma gel in all patients at two months after injection with no significant complications. Jitter, shimmer, maximum, maximum phonation time (MPT) and mean voice handicap index (VHI) also improved significantly after plasma gel injection. However, because the injected plasma gel was gradually absorbed, 6 patients needed another injection, while the gel remained in place in 2 patients. CONCLUSION:Injection laryngoplasty with autologous plasma gel may be a useful and safe treatment option for temporary vocal cord palsy.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Woo SH,Kim JP,Park JJ,Chung PS,Lee SH,Jeong HSdoi
10.3349/ymj.2013.54.6.1516subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1516-23issue
6eissn
0513-5796issn
1976-2437pii
2013111516journal_volume
54pub_type
杂志文章abstract:PURPOSE:High mobility group box 1 (HMGB1) plays a central role in the pathogenesis of sepsis and multiple organ dysfunction syndromes. We investigated the associations of a single nucleotide polymorphism (SNP; rs1045411) in HMGB1 with various clinical parameters, severity, and prognosis in patients with sepsis, severe ...
journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2016.57.1.111
更新日期:2016-01-01 00:00:00
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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pub_type: 杂志文章,评审
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journal_title:Yonsei medical journal
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doi:10.3349/ymj.1998.39.2.109
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
doi:10.3349/ymj.2004.45.1.135
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.1998.39.3.247
更新日期:1998-06-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2014.55.5.1310
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
pub_type: 杂志文章,评审
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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更新日期:2015-05-01 00:00:00
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更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-12-30 00:00:00