Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use.

Abstract:

:Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults with known risk factors of prothrombotic conditions, pregnancy, infection, malignancy, and drugs. Dutasteride is a 5α-reductase inhibitor that is used for benign prostate hypertrophy and androgenetic alopecia. To date, CVT caused by dutasteride use has not been reported. A 25-year-old male presented with headache and diplopia. He had taken 0.5 mg of dutasteride every other day for 9 months to treat alopecia. A headache developed 7 months after he started taking medication, and horizontal diplopia occurred 1 month after the onset of headache. Fundus examination showed bilateral papilledema. Brain magnetic resonance imaging showed thrombosis in the left sigmoid and transverse sinuses. Headache and diplopia improved after discontinuing dutasteride and starting anticoagulation. The results from this case report indicated dutasteride as a potential cause of CVT. Presumably, the increased estrogen level due to dutasteride use caused the formation of a thrombus.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Choi BK,Cheon K,Cho BH,Jung JW,Lee KY

doi

10.3349/ymj.2020.61.6.553

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

553-555

issue

6

eissn

0513-5796

issn

1976-2437

pii

61.553

journal_volume

61

pub_type

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