Abstract：
PURPOSE:Although current guidelines recommend continuing the same antithrombotic strategy regardless of rhythm control after radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF), anticoagulation has a risk of major bleeding. We evaluated the safety of switching warfarin to aspirin in patients with successful AF ablation. MATERIALS AND METHODS:Among 721 patients who underwent RFCA of AF, 608 patients (age, 57.3±10.9 years; 77.0% male, 75.5% paroxysmal AF) who had no evidence of AF recurrence at 3 months post-RFCA were included. We compared the thromboembolic and hemorrhagic events in patients for whom warfarin was switched to aspirin (ASA group; n=296) and patients who were kept on warfarin therapy (W group; n=312). RESULTS:There were no significant differences in CHA₂DS₂-VASc or HAS-BLED scores between the groups. In 30 patients in the ASA group and 37 patients in W group, AF recurred and warfarin was restarted or maintained during the 18.0±12.2 months of follow-up. There were no significant differences in thromboembolic (0.3% vs. 1.0%, p=0.342) and major bleeding incidences (0.7% vs. 0.6%, p=0.958) between ASA and W groups during the follow-up period. In the 259 patients with a CHA₂DS₂-VASc score≥2, there were no significant differences in thromboembolism (0.8% and 2.2%, p=0.380) or major bleeding incidences (0.8% and 1.4%, p=0.640) between ASA and W groups. CONCLUSION:Switching warfarin to aspirin 3 months after successful RFCA of AF could be as safe and efficacious as long-term anticoagulation even in patients with CHA₂DS₂-VASc score≥2. However, strict rhythm monitoring cannot be overemphasized.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Uhm JS,Won H,Joung B,Nam GB,Choi KJ,Lee MH,Kim YH,Pak HNdoi
10.3349/ymj.2014.55.5.1238subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1238-45issue
5eissn
0513-5796issn
1976-2437pii
2014091238journal_volume
55pub_type
杂志文章abstract：:The present study compares neonatal outcome after preterm delivery of infants in pregnancies complicated by the HELLP syndrome or severe preeclampsia (PS). The maternal and neonatal charts of 71 out of a total of 409 pregnancies that were complicated by hypertensive disorders at Severance hospital between January 1995...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2006.47.3.393
更新日期：2006-06-30 00:00:00
abstract：:The Harmonic Scalpel made by Ultracision is a system for endoscopic cutting. The energy source is vibration. The power box is attached to a forceps or blade, and the vibrational frequency of the blade approaches 55,500 cycles/second. This causes a knife-like action of the blade through tissue, with enough heating to c...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1999.40.6.545
更新日期：1999-12-01 00:00:00
abstract：:Calcineurin Inhibitors (CNIs) and Corticosteroids have been the main immunosuppressive agents in solid organ transplantation. Many studies have confirmed the positive impacts of withdrawal/avoidance of these agents, separately, on their side effect profiles. A pilot study was performed avoiding both agents among low-i...
journal_title：Yonsei medical journal
pub_type： 临床试验,杂志文章
doi：10.3349/ymj.2004.45.6.1143
更新日期：2004-12-31 00:00:00
abstract：PURPOSE:The aim of this study was to compare a negative pressure drain with a natural drain in order to determine whether a negative pressure drainage tube causes an increase in the drainage volume. MATERIALS AND METHODS:Sixty-two patients who underwent total thyroidectomy for papillary thyroid carcinoma (PTC) were en...
journal_title：Yonsei medical journal
pub_type： 杂志文章,随机对照试验
doi：10.3349/ymj.2013.54.1.204
更新日期：2013-01-01 00:00:00
abstract：:Different difficulties can be encountered during removal of an intramedullary femoral nail depending partly upon the design of the nail but mainly on bone ingrowth. This possibility is higher in younger patients and when nail removal is attempted long after initial insertion. We present a case of difficult nail remova...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2003.44.6.1083
更新日期：2003-12-30 00:00:00
abstract：PURPOSE:Coronary artery spasm (CAS) and diabetes mellitus (DM) are implicated in endothelial dysfunction, and insulin resistance (IR) is a major etiological cause of type 2 DM. However, the association between CAS and IR in non-diabetic individuals has not been elucidated. The aim of the present study was to evaluate t...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2018.59.9.1057
更新日期：2018-11-01 00:00:00
abstract：PURPOSE:Genetic factors are known to be important in the etiology of bipolar disorder (BD). The fragile sites (FSs) are a very interesting subject for the study of clinical disorders. The aim of this study was to evaluate fragile sites seen in patients with bipolar disorder and find a correlation between some fragile s...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2009.50.1.137
更新日期：2009-02-28 00:00:00
abstract：:The external elastic lamina (EEL) serves as a barrier for cells and macromolecules between the media and adventitia in the vascular wall. We evaluated the morphological changes and quantitative assessments of the EEL architecture in the coronary circulation of pigs fed with a high cholesterol diet. Confocal microscopy...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1999.40.3.273
更新日期：1999-06-01 00:00:00
abstract：PURPOSE:The purpose of this study was to examine a J-shaped relationship between alcohol consumption and depression among the elderly in South Korea. MATERIALS AND METHODS:Cross-section data were drawn from a community-based sample of individuals 60 years of age and older (n=1819). Respondents completed the Alcohol Us...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2015.56.2.418
更新日期：2015-03-01 00:00:00
abstract：:This study was performed to investigate the effects of behavior modification on body image, depression and body fat in obese elementary school children. Sixty-two elementary students of the 4th to 6th grade were selected from two different Seoul schools. Thirty-four children in one school were designated as the experi...
journal_title：Yonsei medical journal
pub_type： 临床试验,杂志文章
doi：10.3349/ymj.2004.45.1.61
更新日期：2004-02-29 00:00:00
abstract：PURPOSE:This study was designed to assess the prevalence and correlates of disturbed eating attitudes and behaviors in South Korean students. MATERIALS AND METHODS:In a cross-sectional survey, 2,226 fourth and seventh grade students filled out questionnaires on eating attitudes and behaviors (Eating Attitude Test -26,...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2010.51.3.302
更新日期：2010-05-01 00:00:00
abstract：PURPOSE:Label adherence for non-vitamin K antagonist oral anticoagulants (NOACs) has not been well evaluated in Asian patients with non-valvular atrial fibrillation (AF). The present study aimed to assess label adherence for NOACs in a Korean AF population and to determine risk factors of off-label prescriptions of NOA...
journal_title：Yonsei medical journal
pub_type： 杂志文章,多中心研究
doi：10.3349/ymj.2019.60.3.277
更新日期：2019-03-01 00:00:00
abstract：PURPOSE:Pulse wave velocity (PWV) is at least partially controlled by vascular tone. Vascular tone and underlying physiological processes such as sympathetic activity, plasma catecholamin, and cortisol levels have been shown to follow diurnal variations. MATERIALS AND METHODS:Carotid-to-radial PWV was non-invasively a...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2007.48.4.665
更新日期：2007-08-31 00:00:00
abstract：PURPOSE:Mitochondrial encephalopathy (ME) is a rare disorder of energy metabolism. The disease course can roughly be evaluated by clinical findings. The purpose of this study was to evaluate metabolic spectral changes using proton MR spectroscopy (MRS), and to establish a way to monitor ME by neuroimaging. MATERIALS A...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2010.51.5.672
更新日期：2010-09-01 00:00:00
abstract：PURPOSE:The conventional trocar and cannula method in peritoneal dialysis (PD) catheter insertion has its limitation in clinical setting. The aim of this study was to compare a modified method for percutaneous PD catheter insertion with the conventional method, and demonstrate advantages of the modified method. MATERI...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2015.56.4.981
更新日期：2015-07-01 00:00:00
abstract：:For the present, to determine growth hormone(GH) deficiency in patients with short stature, many provocative tests using various pharmacological agents such as glucagon, insulin, clonidine, arginine, growth hormone releasing factor, etc. should be done. These are not only complicated but are also misleading in some pa...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1989.30.4.367
更新日期：1989-12-01 00:00:00
abstract：:Antimicrobial resistance surveillance is necessary to determine the size of the problem and to guide empirical selection of antimicrobial agents for treating infected patients. The aim of this study was to analyze the results of susceptibility tests performed by hospitals participating in the Korean Nationwide Surveil...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2003.44.4.571
更新日期：2003-08-30 00:00:00
abstract：PURPOSE:Imbalances between osteogenic and adipogenic differentiation leads to diseases such as osteoporosis. The aim of our study was to demonstrate the differences in extracellular signal-regulated kinase (ERK) phosphorylation during both adipogenesis and osteogenesis of human bone marrow-derived stem cells (BMSCs). ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2011.52.1.165
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:The cytochrome P450 2C19 (CYP2C19) metabolizes arachidonic acid to produce epoxyicosanoid acids, which are involved in vascular tone and regulation of blood pressure. Recent findings suggest that CYP2C19 gene might be considered as a novel candidate gene for treatment of cardiovascular disease. The aim of the p...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2012.53.6.1113
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:Rearrangement of the proto-oncogene rearranged during transfection (RET) has been newly identified potential driver mutation in lung adenocarcinoma. Clinically available tyrosine kinase inhibitors (TKIs) target RET kinase activity, which suggests that patients with RET fusion genes may be treatable with a kinas...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2017.58.1.9
更新日期：2017-01-01 00:00:00
abstract：:Gastrointestinal stromal tumors (GISTs) are rarely noted in association with neurofibromatosis-1 (NF-1, von Recklinghausen disease) as an individual gastrointestinal manifestation. We report here a case of multiple GISTs with an abundant skeinoid fiber in the jejunum of a 43-year-old woman diagnosed as NF-1. Histologi...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2004.45.3.564
更新日期：2004-06-30 00:00:00
abstract：PURPOSE:Continuous cardiac monitoring in a stroke unit (SU) may improve detection of atrial fibrillation (AF), and SU care may improve the rate of anticoagulation by better adherence to a standardized treatment protocol in patients with AF. We investigated the effects of the SU on the detection of AF and the rate of wa...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2013.54.2.301
更新日期：2013-03-01 00:00:00
abstract：PURPOSE:The purpose of this study is to evaluate the clinical results of treatment with a high dose of 3-dimensional conformal boost (3DCB) using a real-time tracking radiation therapy (RTRT) system in cervical cancer patients. MATERIALS AND METHODS:Between January 2001 and December 2004, 10 patients with cervical can...
journal_title：Yonsei medical journal
pub_type： 临床试验,杂志文章
doi：10.3349/ymj.2010.51.1.93
更新日期：2010-01-01 00:00:00
abstract：:We report a case of epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM), which was associated with congenital pyloric atresia (PA) and various urologic abnormalities, a diagnosis confirmed by immunofluorescence mapping and electron microscopic findings. Immunofluorescent mapping showed the serum from a patient ...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2000.41.3.411
更新日期：2000-06-01 00:00:00
abstract：:Eosinophilic gastroenteritis (EG) is characterized by eosinophilic infiltration of the bowel wall and variable gastrointestinal manifestations. Clinicians should have a high index of suspicion for EG when faced with gastrointestinal symptoms and peripheral eosinophilia to avoid incorrect diagnosis and inappropriate tr...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2010.51.1.145
更新日期：2010-01-01 00:00:00
abstract：:Hepatocytes are the primary targets of the hepatitis C virus (HCV). While immunosuppressive roles of HCV core protein have been found in several studies, it remains uncertain whether core protein expressed in hepatocytes rather than in immune cells affects the CD8+ T cell response. In order to transduce genes selectiv...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2005.46.6.827
更新日期：2005-12-31 00:00:00
abstract：PURPOSE:Information on the possible role of the ribosomal protein S15a (RPS15a) in gastric cancer is scarce. The aim of this study was to evaluate the impact of RPS15a gene expression on the growth and cell cycle of gastric cancer cells in vitro and in vivo. MATERIALS AND METHODS:RPS15a mRNA expression was examined in...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2018.59.10.1166
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:We evaluated the validity of robotic surgery (RS) for pediatric choledochal cyst (CC) in comparison to open surgery (OS). MATERIALS AND METHODS:From January 2009 to April 2013, clinical data from 79 consecutive pediatric patients with CC, who underwent RS (n=36) or OS (n=43) performed by a single pediatric sur...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.2015.56.3.737
更新日期：2015-05-01 00:00:00
abstract：:The purpose of this study was to determine the factors which were responsible for delaying early diagnosis and optimal management of rheumatoid arthritis (RA) in Korea. We interviewed 109 outpatients diagnosed as RA being treated by rheumatologists, and we eventually analyzed 98 patients' data. The median length of ti...
journal_title：Yonsei medical journal
pub_type： 杂志文章
doi：10.3349/ymj.1998.39.3.247
更新日期：1998-06-01 00:00:00
abstract：:Living donor liver transplantation (LDLT) was first successfully performed on a child in 1990 and the Shinshu group performed the same procedure on an adult for the first time in 1994. Over the past few years adult LDLT has been increasing worldwide because of the severe shortage of cadaveric organs, especially in loc...
journal_title：Yonsei medical journal
pub_type： 杂志文章,评审
doi：10.3349/ymj.2004.45.6.1076
更新日期：2004-12-31 00:00:00
