Abstract:
PURPOSE:Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections. The aim of this study was to identify risk factors associated with mortality in patients with S. marcescens bacteremia. MATERIALS AND METHODS:We performed a retrospective cohort study of 98 patients who had one or more blood cultures positive for S. marcescens between January 2006 and December 2012 in a tertiary care hospital in Seoul, South Korea. Multiple risk factors were compared with association with 28-day all-cause mortality. RESULTS:The 28-day mortality was 22.4% (22/98 episodes). In a univariate analysis, the onset of bacteremia during the intensive care unit stay (p=0.020), serum albumin level (p=0.011), serum C-reactive protein level (p=0.041), presence of indwelling urinary catheter (p=0.023), and Sequential Oran Failure Assessment (SOFA) score at the onset of bacteremia (p<0.001) were significantly different between patients in the fatal and non-fatal groups. In a multivariate analysis, lower serum albumin level and an elevated SOFA score were independently associated with 28-day mortality [adjusted odds ratio (OR) 0.206, 95% confidential interval (CI) 0.044-0.960, p=0.040, and adjusted OR 1.474, 95% CI 1.200-1.810, p<0.001, respectively]. CONCLUSION:Lower serum albumin level and an elevated SOFA score were significantly associated with adverse outcomes in patients with S. marcescens bacteremia.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Kim SB,Jeon YD,Kim JH,Kim JK,Ann HW,Choi H,Kim MH,Song JE,Ahn JY,Jeong SJ,Ku NS,Han SH,Choi JY,Song YG,Kim JMdoi
10.3349/ymj.2015.56.2.348subject
Has Abstractpub_date
2015-03-01 00:00:00pages
348-54issue
2eissn
0513-5796issn
1976-2437pii
201503348journal_volume
56pub_type
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journal_title:Yonsei medical journal
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doi:10.3349/ymj.2011.52.1.165
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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doi:10.3349/ymj.2007.48.4.665
更新日期:2007-08-31 00:00:00
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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更新日期:1998-10-01 00:00:00
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journal_title:Yonsei medical journal
pub_type: 杂志文章
doi:10.3349/ymj.2003.44.2.288
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