Abstract:
PURPOSE:Spontaneous bacterial peritonitis (SBP) frequently develops in patients with liver cirrhosis; however, there is little data to suggest whether the acquisition site of infection influences the prognosis. This study compared the bacteriology, clinical characteristics and treatment outcomes of community-acquired SBP (CA-SBP) and nosocomial SBP (N-SBP). MATERIALS AND METHODS:The medical records of 130 patients with hepatitis B virus (HBV)-related liver cirrhosis, who had experienced a first episode of SBP between January 1999 and December 2008, were reviewed. RESULTS:The study population included 111 (85.4%) patients with CA-SBP and 19 (14.6%) patients with N-SBP. Baseline and microbiological characteristics as well as clinical course, including in-hospital mortality, did not differ between patients with CA-SBP and those with N-SBP (all p>0.05). The median survival time was 6.5 months, and 117 (90.0%) patients died during the follow-up period. Patients with CA-SBP and N-SBP survived for median periods of 6.6 and 6.2 months, respectively, without significant difference (p=0.569). Time to recurrence did not differ between patients with CA-SBP and N-SBP (4.7 vs. 3.6 months, p=0.925). CONCLUSION:The acquisition site of infection did not affect clinical outcomes for patients with HBV-related liver cirrhosis who had experienced their first episode of SBP. Third-generation cephalosporins may be effective in empirically treating these patients, regardless of the acquisition site of the infection.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Kim SU,Chon YE,Lee CK,Park JY,Kim DY,Han KH,Chon CY,Kim S,Jung KS,Ahn SHdoi
10.3349/ymj.2012.53.2.328subject
Has Abstractpub_date
2012-03-01 00:00:00pages
328-36issue
2eissn
0513-5796issn
1976-2437pii
201203328journal_volume
53pub_type
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journal_title:Yonsei medical journal
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Yonsei medical journal
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pub_type: 杂志文章
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journal_title:Yonsei medical journal
pub_type: 杂志文章,已发布勘误
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journal_title:Yonsei medical journal
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pub_type: 杂志文章
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