Relationship of CagA to serum gastrin concentrations and antral G, D cell densities in Helicobacter pylori infection.

Abstract:

:The purpose of this study was to investigate whether the densities of antral gastrin and somatostatin-immunoreactive cells in Helicobacter pylori (H. pylori) infection were related to the bacterial expression of cytotoxin-associated gene A (CagA). 32 patients who had underwent diagnostic esophagogastroduodenoscopy were studied. On the histologic examination all patients had antral gastritis. We divided the subjects into three groups. Group I consisted of 6 patients who had chronic superficial gastritis, group II, 9 patients who had H. pylori-associated gastritis but with no expression of CagA, and group III, 17 patients who had H. pylori-associated gastritis with the expression of CagA. In group I and II, serum gastrin levels, and antral G cell and D-cell were measured. In group III, serum gastrin levels, and antral G cell and D-cell were measured, before and after the eradication of H. pylori. The results were as follows. Firstly, serum gastrin concentrations were significantly higher in the patients with H. pylori infection than in the negative controls. Nextly, there was no correlation between the changes in antral G or D-cell density and H. pylori infection. Thirdly, group III had a significant increase in serum gastrin concentrations and a significant decrease in antral D-cell density than group I. Forthly, eradication of H. pylori in group III showed a significantly increased antral D-cell density. Our results suggest that hypergastrinemia in H. pylori-associated gastritis is relevant to the presence of CagA, and the possible mechanism of hypergastrinemia may be related to antral D-cell deficiency, which is caused by H. pylori infection with the expression of CagA.

journal_name

Yonsei Med J

journal_title

Yonsei medical journal

authors

Kim JH,Park HJ,Cho JS,Lee KS,Lee SI,Park IS,Kim CK

doi

10.3349/ymj.1999.40.4.301

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

301-6

issue

4

eissn

0513-5796

issn

1976-2437

journal_volume

40

pub_type

杂志文章
  • Changes in treatment outcomes of gastric cancer surgery over 45 years at a single institution.

    abstract:PURPOSE:Although many studies have demonstrated improvements in short-and long-term outcomes of gastric cancer surgery, changes in long-term survival over time are not well-established. This study was conducted to evaluate changes in host, tumor, and treatment factors in patients treated at a single institution over a ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2008.49.3.409

    authors: Hyung WJ,Kim SS,Choi WH,Cheong JH,Choi SH,Kim CB,Noh SH

    更新日期:2008-06-30 00:00:00

  • Consolidations in nodular bronchiectatic Mycobacterium avium complex lung disease: Mycobacterium avium complex or other infection?

    abstract:PURPOSE:The objective of this study is to define the clinical implications of consolidations in nodular bronchiectatic type Mycobacterium avium complex (NBMAC) infection. MATERIALS AND METHODS:A total of 69 patients (M : F = 17 : 52; mean age, 64 years; age range, 41-85 years) with MAC isolated in the sputum culture a...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2010.51.4.546

    authors: Im SA,Park HJ,Park SH,Chun HJ,Jung WS,Kim SH

    更新日期:2010-07-01 00:00:00

  • Hydrogen peroxide as an effective disinfectant for Pasteurella multocida.

    abstract::Pasteurella multocida (P. multocida) infections vary widely, from local infections resulting from animal bites and scratches to general infections. As of yet, no vaccine against P. multocida has been developed, and the most effective way to prevent pathogenic transmission is to clean the host environment using disinfe...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,收录出版

    doi:10.3349/ymj.2014.55.4.1152

    authors: Jung IS,Kim HJ,Jung WY,Kim CW

    更新日期:2014-07-01 00:00:00

  • Helicobacter pylori: bacterial strategy for incipient stage and persistent colonization in human gastric niches.

    abstract::Helicobacter pylori (H. pylori) undergoes decades long colonization of the gastric mucosa of half the population in the world to produce acute and chronic gastritis at the beginning of infection, progressing to more severe disorders, including peptic ulcer disease and gastric cancer. Prolonged carriage of H. pylori is...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2014.55.6.1453

    authors: Rhee KH,Park JS,Cho MJ

    更新日期:2014-11-01 00:00:00

  • CT and MR findings of primary cardiac lymphoma: report upon 2 cases and review.

    abstract::Although primary cardiac lymphoma was a near fatal disease in the past, recent advances in imaging diagnosis and chemotherapy have dramatically improved survival. We describe the CT and MR findings of primary cardiac lymphoma in two immunocompetent subjects who recovered after chemotherapy. The primary cardiac lymphom...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2001.42.4.451

    authors: Ryu SJ,Choi BW,Choe KO

    更新日期:2001-08-01 00:00:00

  • Association between Atrial Fibrillation and Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease.

    abstract:PURPOSE:Non-alcoholic fatty liver disease (NAFLD) is independently associated with the development of atrial fibrillation (AF). However, the association of AF with advanced liver fibrosis, which is related to all-cause, cardiovascular, and liver-related mortality, has not been established in NAFLD patients. We aimed to...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2020.61.10.860

    authors: Kang MK,Park JG,Kim MC

    更新日期:2020-10-01 00:00:00

  • Comparison of diagnostic performance of three real-time PCR kits for detecting Mycobacterium species.

    abstract:PURPOSE:PCR is widely used for rapidly and accurately detecting Mycobacterium species. The purpose of this study was to assess the diagnostic performance of three real-time PCR kits and evaluate the concordance with two older PCR methods. MATERIALS AND METHODS:Using 128 samples, the five PCR methods were assessed, inc...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2011.52.2.301

    authors: Cho SY,Kim MJ,Suh JT,Lee HJ

    更新日期:2011-03-01 00:00:00

  • Effects of epithelium on the mechanism of mediator release from guinea pig tracheal tissues sensitized by IgG1 versus IgE antibody.

    abstract::In the present work, we have examined the effect of PAF, removal of epithelium, the mechanism of desensitization, and the substances that increases the level of intracellular c-AMP on the differences of mediator release from superfused tracheal strips after passive sensitization with IgG1 versus IgE Ab. In the passive...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1995.36.2.161

    authors: Ro JY,Kim KH

    更新日期:1995-05-01 00:00:00

  • Simultaneous Closure of a Left Atrial Appendage through an Atrial Septal Defect and the Atrial Septal Defect.

    abstract::Left atrial appendage (LAA) occlusion can be employed as an alternative treatment to oral anticoagulation in patients with atrial fibrillation to prevent embolic events. Atrial septal defect (ASD) may be related with right heart dysfunction and allow paradoxical embolism to occur. However, occlusion of both LAA throug...

    journal_title:Yonsei medical journal

    pub_type:

    doi:10.3349/ymj.2017.58.6.1237

    authors: Song S,Lee OH,Kim JS,Cho IJ,Shim CY,Hong GR,Pak HN,Jang Y

    更新日期:2017-11-01 00:00:00

  • Imaging findings of giant liposarcoma of the esophagus.

    abstract::A giant esophageal liposarcoma showing rapid growth over 7 months is presented in 56-year-old man. It originated from the pharyngo-esophageal junction with a short stalk, and extended downward to the distal esophagus. A barium swallow study showed a large, sausage-like intraluminal mass in the dilated esophagus. CT an...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.4.715

    authors: Chung JJ,Kim MJ,Kim JH,Lee JT,Yoo HS,Kim KW

    更新日期:2003-08-30 00:00:00

  • Pulse oximetry during shunt surgery in pediatric patients with tetralogy of fallot.

    abstract::Pulse oximetry is a noninvasive technique for measuring O2 saturation (SpO2) continuously. We applied pulse oximetry to 9 pediatric patients with tetralogy of Fallot during shunt surgery. Arterial oxygen tensions (PaO2) and saturations (SaO2) were also measured at the time of postinduction, just before the shunt, afte...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1989.30.1.12

    authors: Oh HK,Park WK,Nam SH,Bang SO

    更新日期:1989-01-01 00:00:00

  • Utilization characteristics of health care service for rheumatoid arthritis patients in Korea.

    abstract::The purpose of this study was to determine the factors which were responsible for delaying early diagnosis and optimal management of rheumatoid arthritis (RA) in Korea. We interviewed 109 outpatients diagnosed as RA being treated by rheumatologists, and we eventually analyzed 98 patients' data. The median length of ti...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1998.39.3.247

    authors: Cho KJ,Jang SH,Lee SK,Doh WS

    更新日期:1998-06-01 00:00:00

  • A Single-Center, Retrospective Study of Bevacizumab-Containing Neoadjuvant Chemotherapy followed by Interval Debulking Surgery for Ovarian Cancer.

    abstract:PURPOSE:We evaluated whether adding bevacizumab to current platinum-based chemotherapy could improve clinical outcomes without affecting safety. MATERIALS AND METHODS:We retrospectively reviewed medical records of patients with pathologically confirmed ovarian cancer who received neoadjuvant chemotherapy (NAC) at Yons...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2020.61.4.284

    authors: Park J,Eoh KJ,Nam EJ,Kim S,Kim SW,Kim YT,Lee JY

    更新日期:2020-04-01 00:00:00

  • Real World Experience of Telbivudine Versus Entecavir in Patients with Chronic Hepatitis B, Including Long-Term Outcomes after Treatment Modification.

    abstract:PURPOSE:To estimate long-term outcomes after treatment modification in patients with chronic hepatitis B (CHB) treated with entecavir (ETV) and telbivudine (LdT). MATERIALS AND METHODS:The study enrolled 131 nucleos(t)ide analogue (NA)-naïve CHB patients treated with ETV or LdT. During the 3-year study, NA treatment h...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2018.59.3.383

    authors: Choi JW,Kim SH,Seo JH,Cho YS,Won SY,Park BK,Jeon HH,Lee YK,Lee CK

    更新日期:2018-05-01 00:00:00

  • Exploring the non-linear relationship between alcohol consumption and depression in an elderly population in Gangneung: the Gangneung Health Study.

    abstract:PURPOSE:The purpose of this study was to examine a J-shaped relationship between alcohol consumption and depression among the elderly in South Korea. MATERIALS AND METHODS:Cross-section data were drawn from a community-based sample of individuals 60 years of age and older (n=1819). Respondents completed the Alcohol Us...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2015.56.2.418

    authors: Kim SA,Kim E,Morris RG,Park WS

    更新日期:2015-03-01 00:00:00

  • Revolution and refinement of surgical techniques for living donor partial liver transplantation.

    abstract::Living donor liver transplantation (LDLT) was first successfully performed on a child in 1990 and the Shinshu group performed the same procedure on an adult for the first time in 1994. Over the past few years adult LDLT has been increasing worldwide because of the severe shortage of cadaveric organs, especially in loc...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2004.45.6.1076

    authors: Dulundu E,Sugawara Y,Makuuchi M

    更新日期:2004-12-31 00:00:00

  • RETT's syndrome in Korea--report of two cases.

    abstract::Rett's syndrome(RS) is a progressive neurodegenerative disorder characterized by exclusive occurrence in females, autistic behavior, dementia, gait ataxia, loss of purposeful use of the hands with stereotypic hand movement, and seizures. Initially RS was considered to be very rare; however, recent reports suggest that...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.1991.32.2.172

    authors: Choi YC,Lee BI,Huh K,Kim GW

    更新日期:1991-06-01 00:00:00

  • Clinical usefulness of magnetic resonance cisternography in patients having hemifacial spasm.

    abstract::To evaluate the usefulness of MR cisternography fourteen patients that had hemifacial spasm and 20 control patients underwent MR cisternography. All the patients with hemifacial spasm had a confirmed vascular compression after surgery. MR cisternography was performed using a 1.5-tesla superconducting MR magnet in whic...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2001.42.4.390

    authors: Lee MS,Kim MS,Hong IS,Whang K,Han YP

    更新日期:2001-08-01 00:00:00

  • Clinicopathologic characteristics associated with complications and long-term outcomes of endoscopic papillectomy for adenoma.

    abstract:PURPOSE:Endoscopic papillectomy (EP) is currently employed for the treatment of ampullary adenoma. This study aimed to evaluate the clinical, endoscopic, and histologic characteristics related to complications and long-term outcomes of EP. MATERIALS AND METHODS:Thirty-nine patients underwent EP for ampullary adenoma. ...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2014.55.3.644

    authors: Shim CN,Chung MJ,Bang S,Park SW,Song SY,Chung JB,Park JY

    更新日期:2014-05-01 00:00:00

  • Eosinophilic gastroenteritis with eosinophilic dermatitis.

    abstract::Eosinophilic gastroenteritis (EG) is characterized by eosinophilic infiltration of the bowel wall and variable gastrointestinal manifestations. Clinicians should have a high index of suspicion for EG when faced with gastrointestinal symptoms and peripheral eosinophilia to avoid incorrect diagnosis and inappropriate tr...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2010.51.1.145

    authors: Cha JM,Lee JI,Joo KR,Shin HP

    更新日期:2010-01-01 00:00:00

  • A case of superficial epithelioma with sebaceous differentiation.

    abstract::Superficial epithelioma with sebaceous differentiation (SESD) is a rare benign neoplasm with peculiar histopathologic characteristics, which occurs in aged skin. We report upon a case of SESD occurring on the left upper back, which histopathologically is a superficial, multilobular tumor with numerous basaloid cells m...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2003.44.2.347

    authors: Lee MJ,Kim YC,Lew W

    更新日期:2003-04-30 00:00:00

  • A case of immunoglobulin E mediated anaphylaxis to levodropropizine.

    abstract::We experienced a case of immunoglobulin E (IgE) mediated anaphylaxis to levodropropizine. The patient was an 18-year old Korean woman. After taking the common cold medication including acetaminophen, domperidone, and levodropropizine, skin rash, angioedema and anaphylaxis were developed immediately. As she was tolerab...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2013.54.1.262

    authors: Park KH,Yun IS,Choi SY,Lee JH,Hong CS,Park JW

    更新日期:2013-01-01 00:00:00

  • Morphological characteristics of the developing human brain during the embryonic period.

    abstract::Many features of the developing nervous system are visible from external observations of intact human embryos. In this study, a photographic atlas from the 4th to the 7th week after ovulation (Carnegie stages 10-18) is provided. The neural folds began to fuse at stage 10, and the rostral and caudal neuropore were clos...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.1997.38.1.26

    authors: Yoon H,Shin YS,Lee KC,Park HW

    更新日期:1997-02-01 00:00:00

  • Association of the adiponectin gene variations with risk of ischemic stroke in a Korean population.

    abstract:PURPOSE:Stroke is the second leading cause of death and a major cause of morbidity and mortality worldwide. Evidence of variations in adiponectin (AdipoQ) genes that are associated with ischemic stroke has not been consistent, and it is unclear whether the same loci contribute to these associations in the Korean popula...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2011.52.1.20

    authors: Cheong MY,Bang OS,Cha MH,Park YK,Kim SH,Kim YJ

    更新日期:2011-01-01 00:00:00

  • Multidrug-resistant Acinetobacter spp.: increasingly problematic nosocomial pathogens.

    abstract::Pathogenic bacteria have increasingly been resisting to antimicrobial therapy. Recently, resistance problem has been relatively much worsened in Gram-negative bacilli. Acinetobacter spp. are typical nosocomial pathogens causing infections and high mortality, almost exclusively in compromised hospital patients. Acineto...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章,评审

    doi:10.3349/ymj.2011.52.6.879

    authors: Lee K,Yong D,Jeong SH,Chong Y

    更新日期:2011-11-01 00:00:00

  • Granular Cell Tumors on Unusual Anatomic Locations.

    abstract::Granular cell tumors (GCTs) are soft tissue tumors, which are thought to be derived from Schwann cells. Although most GCTs are reported to arise in tongue and oral cavity (30-50%), they can appear on any anatomic sites, even visceral organs. Herein, we report 5 cases of GCTs on unusual anatomic locations, such as palm...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2015.56.6.1731

    authors: Kim HJ,Lee MG

    更新日期:2015-11-01 00:00:00

  • Robotic colorectal surgery.

    abstract::Robotic colorectal surgery has gradually been performed more with the help of the technological advantages of the da Vinci system. Advanced technological advantages of the da Vinci system compared with standard laparoscopic colorectal surgery have been reported. These are a stable camera platform, three-dimensional im...

    journal_title:Yonsei medical journal

    pub_type: 历史文章,杂志文章,评审

    doi:10.3349/ymj.2008.49.6.891

    authors: Baik SH

    更新日期:2008-12-31 00:00:00

  • The expression of folate sensitive fragile sites in patients with bipolar disorder.

    abstract:PURPOSE:Genetic factors are known to be important in the etiology of bipolar disorder (BD). The fragile sites (FSs) are a very interesting subject for the study of clinical disorders. The aim of this study was to evaluate fragile sites seen in patients with bipolar disorder and find a correlation between some fragile s...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2009.50.1.137

    authors: Demirhan O,Tastemir D,Sertdemir Y

    更新日期:2009-02-28 00:00:00

  • Polypoidal choroidal vasculopathy in Korean patients with large submacular hemorrhage.

    abstract:PURPOSE:To determine and compare the clinical characteristics, visual prognosis and treatment of hemorrhagic polypoidal choroidal vasculopathy (HPCV) with those of hemorrhagic choroidal neovascularization (HCNV) due to age-related macular degeneration (ARMD). MATERIALS AND METHODS:Retrospective analysis of 44 consecut...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2007.48.2.225

    authors: Yoon JS,Lee J,Lee SC,Koh HJ,Kim SS,Kwon OW

    更新日期:2007-04-30 00:00:00

  • The expression of estrogen receptors in hepatocellular carcinoma in Korean patients.

    abstract::Expression of estrogen receptors (ER)-alpha and -beta, as well as androgen receptor (AR), in hepatocellular carcinoma (HCC) is thought to be correlated with prognosis, survival, and male prevalence of HCC. These hypotheses are based on investigations of European patients; however the expression patterns of these recep...

    journal_title:Yonsei medical journal

    pub_type: 杂志文章

    doi:10.3349/ymj.2006.47.6.811

    authors: Wang AG,Lee KY,Kim SY,Choi JY,Lee KH,Kim WH,Wang HJ,Kim JM,Park MG,Yeom YI,Kim NS,Yu DY,Lee DS

    更新日期:2006-12-31 00:00:00