Abstract:
:Expression of estrogen receptors (ER)-alpha and -beta, as well as androgen receptor (AR), in hepatocellular carcinoma (HCC) is thought to be correlated with prognosis, survival, and male prevalence of HCC. These hypotheses are based on investigations of European patients; however the expression patterns of these receptors in Asian patients are largely unknown. In this study, we collected liver carcinoma and peritumor tissues from 32 patients (9 females and 23 males) in South Korea. The expression of ERs and ARs was studied using RT-PCR. Wild-type ER-alpha and AR were expressed in all of the samples investigated, and their expression was independent of the causal virus or patient sex. Expression of the ER-alpha variant was independent of sex (100% female vs. 91.3% male) and HCV and HBV status (91.3% vs. 100%). Wild-type ER-beta was expressed more often in HCV patients than in HBV patients (95.7% vs. 44.4%; p < 0.05). In conclusion, the stronger ER-alpha variant expression in HCC tissues implies that this variant has an important role in HCC development. However, at least in Korean patients, expression of the ER-alpha variant (vER-alpha) is not related to male HCC prevalence. In addition, the predominant expression of ER-beta in HCV patients suggests that it plays an important role in HCV-induced liver disease.
journal_name
Yonsei Med Jjournal_title
Yonsei medical journalauthors
Wang AG,Lee KY,Kim SY,Choi JY,Lee KH,Kim WH,Wang HJ,Kim JM,Park MG,Yeom YI,Kim NS,Yu DY,Lee DSdoi
10.3349/ymj.2006.47.6.811subject
Has Abstractpub_date
2006-12-31 00:00:00pages
811-6issue
6eissn
0513-5796issn
1976-2437pii
200612811journal_volume
47pub_type
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journal_title:Yonsei medical journal
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journal_title:Yonsei medical journal
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