Abstract:
:Mycobacterium avium ssp. paratuberculosis (M. paratuberculosis), the causative agent of Johne's disease, is an important animal pathogen that has also been implicated in human disease. The major proteins expressed by M. paratuberculosis were analyzed by two-dimensional gel electrophoresis, and a superoxide dismutase (Sod) was identified from this protein profile. The M. paratuberculosis Sod has a molecular mass of 23 kDa and an isoelectric point of 6.1. Sequence analysis of the corresponding sodA gene from M. paratuberculosis indicates that this protein is a manganese-dependent enzyme. We show that the M. paratuberculosis Sod is actively secreted, suggesting that it may elicit a protective cellular immune response in the host during infection.
journal_name
FEMS Microbiol Lettjournal_title
FEMS microbiology lettersauthors
Liu X,Feng Z,Harris NB,Cirillo JD,Bercovier H,Barletta RGdoi
10.1111/j.1574-6968.2001.tb10809.xkeywords:
subject
Has Abstractpub_date
2001-08-21 00:00:00pages
233-8issue
2eissn
0378-1097issn
1574-6968pii
S0378109701003251journal_volume
202pub_type
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