Abstract:
BACKGROUND:Bone morphogenetic proteins (BMPs) have shown considerable promise as a therapeutic agent to enhance periodontal regeneration although the optimal characteristics of a suitable release system are not known. AIM:The aim of this study was to compare the effects of slow and fast degrading gelatin carriers on BMP-2-induced periodontal healing. METHOD:Recombinant human bone morphogenetic protein-2 (rhBMP-2) was incorporated into gelatin and subsequently differentially cross-linked to produce slow and fast release carrier systems. Release kinetics were confirmed in vitro, by measuring release of 125I-growth hormone from similar gelatin plugs. Effects of BMP were evaluated in surgically created rat periodontal fenestration defects which were processed for histology 10 days post-operatively. The rats were divided into 4 groups and the control defects were treated with either slow or fast degrading gelatin (CONs or CONf respectively), whilst test groups were treated with 1.25 microg rhBMP-2 in the slow or fast degrading gelatin (BMPs or BMPf respectively). RESULTS:BMPf greatly increased bone formation compared with the control (CONf) (1.67 +/- 0.65 versus 0.34 +/- 0.11 x 10(-4) m2), but no significant differences were observed with BMPs and CONs. In contrast, new cementum formation was significantly greater in the BMPs group compared with all other groups (p<0.05). CONCLUSION:Release kinetics of BMP may have important effects on the outcome of BMP-induced periodontal regeneration. New bone formation may be affected by rapid-release kinetics although further investigation is necessary to confirm this. In contrast, new cementum formation is promoted by slow release of BMP.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
Talwar R,Di Silvio L,Hughes FJ,King GNdoi
10.1034/j.1600-051x.2001.028004340.xkeywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
340-7issue
4eissn
0303-6979issn
1600-051Xjournal_volume
28pub_type
杂志文章abstract:BACKGROUND:The aim of this Systematic Review (SR) was to assess the clinical efficacy of periodontal plastic surgery procedures in the treatment of localized gingival recessions (Rec) with or without inter-dental clinical attachment loss (iCAL). MATERIAL AND METHODS:Electronic and hand searches were performed to ident...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,评审
doi:10.1111/jcpe.12182
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The non-communicable diseases dental caries and periodontal diseases pose an enormous burden on mankind. The dental biofilm is a major biological determinant common to the development of both diseases, and they share common risk factors and social determinants, important for their prevention and control. The...
journal_title:Journal of clinical periodontology
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1111/jcpe.12687
更新日期:2017-03-01 00:00:00
abstract::Gingival ulcers caused by tooth brushing in 13 patients with an average age of 29.9 years are presented. The lesions show characteristic clinical features not compatible with simple traumatic ulcers, e.g. running a more chronical course, the duration averaging 6.5 months. Repeated trauma and, in some cases, infection ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1982.tb02057.x
更新日期:1982-05-01 00:00:00
abstract:AIM:We aimed to investigate the association of periodontitis and oral hygiene indicators with changes in blood lipid parameters in a nationwide, population-based cohort in a longitudinal setting. MATERIALS AND METHODS:We included nationwide health screening program participants who underwent oral health examination in...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/jcpe.13373
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Peri-implant soft tissue may be critical to prevent inflammation and promote gingival margin stability. The purpose of this randomized clinical trial (RCT) is to compare xenogeneic collagen matrix (XCM) versus connective tissue graft (CTG) to increase buccal soft tissue thickness at implant site. MATERIALS ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jcpe.12750
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To determine the concentration of cathepsin K secreted into the crevicular fluid around dental implants and its correlation with clinical parameters of healthy implants and implants showing clinical signs of peri-implantitis. MATERIAL AND METHODS:Nineteen patients with 40 implants with and without peri-impla...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2006.00904.x
更新日期:2006-04-01 00:00:00
abstract:AIM:This systematic review investigates the impact of specific interventions aiming at promoting behavioural changes to improve oral hygiene (OH) in patients with periodontal diseases. METHODS:A literature search was performed on different databases up to March 2019. Randomized and non-randomized controlled trials eva...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/jcpe.13234
更新日期:2020-07-01 00:00:00
abstract:AIM:To investigate the association of the Periodontal Risk Assessment (PRA) model categories with periodontitis recurrence and tooth loss during supportive periodontal therapy (SPT) and to explore the role of patient compliance. MATERIAL AND METHODS:In a retrospective cohort, PRA was performed for 160 patients after a...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2009.01508.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:Investigate the association between the frequency of alcohol consumption and periodontitis. Moreover, evaluate the influence of biological, behavioural, and social risk variables in this association. METHODS:Sample was comprised by 542 subjects of both genders, 35-55 years of age, who underwent a complete pe...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2011.01809.x
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:To study the short-term microbiological changes following full-mouth compared with quadrant wise scaling and root planing (FMRP and QRP) as well as long-term effects. METHOD:Twenty patients with chronic periodontitis were randomized into a test group treated in two sessions with subgingival scaling and root...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-051X.2006.01035.x
更新日期:2007-02-01 00:00:00
abstract::This controlled clinical trial evaluated the potential of fibrin glue as a biological carrier to locally deliver guided tissue regeneration (GTR) modulators, 2 controlateral, morphologically similar defects were selected in each of 11 patients and randomly assigned to the test (teflon membrane and fibrin glue) and the...
journal_title:Journal of clinical periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-051x.1995.tb00829.x
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) is undiagnosed in approximately 1/2 of the patients actually suffering from the disease. In addition, the prevalence of DM is more than 2x as high in patients with periodontitis when compared to periodontally healthy subjects. Thus, a high number of patients with periodontitis may have...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.2002.290306.x
更新日期:2002-03-01 00:00:00
abstract::In a cross-sectional, epidemiological study of phenytoin induced gingival overgrowth in 77 institutionalized persons with epilepsy, the severity of the gum lesions was quantified by means of a precise new technique. Lesion severity was then compared statistically to other clinical and laboratory parameters. Positive c...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1984.tb02214.x
更新日期:1984-04-01 00:00:00
abstract::The objective of this study was to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) concentration on regeneration of alveolar bone and cementum, and on associated root resorption and ankylosis. Contralateral, critical size, supra-alveolar, periodontal defects were surgically produced and...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.1999.260610.x
更新日期:1999-06-01 00:00:00
abstract::In this study, an assessment using modified periodontal indices was done on a group of 48 fully edentulous patients who had each been treated with 3 porous-coated (EndoPore) dental implants and a mandibular overdenture. Parameters assessed included plaque index (PI), sulcular bleeding index (SBI), pocket probing depth...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1996.tb01819.x
更新日期:1996-06-01 00:00:00
abstract:AIM:The aim of this study was to test whether or not soft tissue augmentation with a collagen matrix (VCMX) leads to a similar increase in ridge width around dental implants compared to the use of an autogenous subepithelial connective tissue graft (SCTG). MATERIALS AND METHODS:In 12 dogs, immediate dental implants we...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/jcpe.12635
更新日期:2017-02-01 00:00:00
abstract::This study examined the effects of tetracycline hydrochloride (TCN) and chlorhexidine gluconate (CHX) on the growth and viability of Candida albicans. Subcultures of Candida albicans on Sabouraud's agar, were divided into 5 treatment groups: group 1, untreated control; group 2, 0.12% CHX; group 3, 3.0 mg/ml TCN adjust...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1997.tb00193.x
更新日期:1997-10-01 00:00:00
abstract::The association between subgingival temperature, other clinical characteristics, and the subgingival microbiota was examined in adult subjects with initial periodontitis and differing levels of gingival inflammation. 43 subjects were measured at 6 sites per tooth for pocket depth, attachment level, presence of plaque,...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1998.tb02371.x
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of an orally administered probiotic on the oral microbiota. METHODS:A placebo-controlled, parallel study was conducted in 40 gingivitis subjects during 8 weeks. Treatment consisted on the administration of a daily tablet, either containing Lactobacillus reuteri or placebo. Unstimul...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-051X.2012.01914.x
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Patients preconceptions of periodontal therapy have not been extensively studied and are poorly understood. AIMS:To register specific anxieties and preconceptions held by patients referred for specialist periodontal treatment and to investigate the risks such patients were prepared to take of progressive pe...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.2001.280811.x
更新日期:2001-08-01 00:00:00
abstract:AIM:To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. MATERIAL AND METHODS:A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed p...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jcpe.12290
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND AIM:Tobacco users and especially cigarette smokers are at higher risk than non-smokers for periodontal disease. The pathogenic mechanism has been proposed to be the vasoconstrictive properties of nicotine, with reduced gingival blood flow (GBF) as a contributing factor in the development of periodontal d...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.2002.290911.x
更新日期:2002-09-01 00:00:00
abstract::In the present study, radiographs of a model simulating several degrees of alveolar bone height were taken at different vertical projection angles. Bone height was measured by three examiners utilizing a projection technique similar to that originally employed by Björn et al. (1966, 1969). Correlation coefficients of ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1981.tb00896.x
更新日期:1981-12-01 00:00:00
abstract:AIM:Anti-cardiolipin (CL) antibodies can be induced in Buerger disease (BD), an inflammatory occlusive disorder affecting peripheral blood vessels, in response to bacteria bearing homology to the TLRVYK peptide of a phospholipid-binding plasma protein beta-2-glycoprotein I. TLRVYK homologies are present in Porphyromona...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2009.01467.x
更新日期:2009-10-01 00:00:00
abstract:AIMS:The aim of this split-mouth study was to investigate levels of tumour necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta2) and interleukin-1 beta (IL-1beta) in gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) after a 21-day-period of de novo plaque accumulation in ...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2008.01224.x
更新日期:2008-06-01 00:00:00
abstract:AIM:This study evaluated the effects of 5-fluorouracil (5-FU) and cisplatin (CIS) in healthy periodontal tissues and in the early stages of experimental periodontitis (EP) in rats. METHODS:One hundred and eighty male rats were divided into three groups, which were submitted to the following systemic treatments: physio...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/jcpe.13101
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND/AIMS:Periodontal infections with Actinobacillus actinomycetemcomitans seem to be refractory to conventional therapy. The aim of the present study was to test the in vitro susceptibilities of A. actinomycetemcomitans strains to a panel of seven orally administrable antibiotics. METHODS:A total of 60 isolates...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1034/j.1600-051x.2002.290810.x
更新日期:2002-08-01 00:00:00
abstract:AIM:The study was set to evaluate the validity of subjective jaw bone quality assessment. MATERIALS AND METHODS:A total of 298 patients (198 females, mean age 56.4) were treated with oral implants at the Periodontology Department at the University Hospital of KUL. A total of 761 TiUnite implants have been installed. S...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051X.2007.01047.x
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:The primary aim was to address the following focused question: What is the clinical effect of laser application compared with mechanical debridement in non-surgical periodontal therapy in patients with chronic periodontitis? A secondary aim was to survey the relevant literature in relation to safety of laser...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1600-051X.2008.01259.x
更新日期:2008-09-01 00:00:00
abstract::The measurement process of attachment loss has been criticized in recent years. Problems with clinical interpretation, precision of the measurement, and statistical manipulation of the obtained data, are some of the problems associated with the present methodology. The purpose of the present study was to propose an al...
journal_title:Journal of clinical periodontology
pub_type: 杂志文章
doi:10.1111/j.1600-051x.1989.tb01645.x
更新日期:1989-04-01 00:00:00