Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. A randomized clinical trial.

Abstract:

OBJECTIVE:To investigate the effects of an orally administered probiotic on the oral microbiota. METHODS:A placebo-controlled, parallel study was conducted in 40 gingivitis subjects during 8 weeks. Treatment consisted on the administration of a daily tablet, either containing Lactobacillus reuteri or placebo. Unstimulated saliva and subgingival samples were collected and analysed by culture and PCR. Clinical and microbiological outcome variables were compared between and within groups. RESULTS:There were no significant changes between and within the groups in the clinical variables. In saliva, total anaerobic counts after 4 weeks (p = 0.021) and counts of Prevotella intermedia after 8 weeks (p = 0.030), showed reductions in the test group. In subgingival samples, significant reductions in the changes baseline to 4 weeks were observed for P. gingivalis counts (p = 0.008). With PCR, L. reuteri ATCC-PTA-5289 was more frequently detected than L. reuteri DSM-17938. CONCLUSIONS:The effect of L. reuteri administered in tablets resulted in a reduction in the number of selected periodontal pathogens in the subgingival microbiota, without an associated clinical impact.

journal_name

J Clin Periodontol

authors

Iniesta M,Herrera D,Montero E,Zurbriggen M,Matos AR,Marín MJ,Sánchez-Beltrán MC,Llama-Palacio A,Sanz M

doi

10.1111/j.1600-051X.2012.01914.x

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

736-44

issue

8

eissn

0303-6979

issn

1600-051X

journal_volume

39

pub_type

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