Antineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitis.

Abstract:

AIM:This study evaluated the effects of 5-fluorouracil (5-FU) and cisplatin (CIS) in healthy periodontal tissues and in the early stages of experimental periodontitis (EP) in rats. METHODS:One hundred and eighty male rats were divided into three groups, which were submitted to the following systemic treatments: physiological saline solution (PSS); CIS and 5FU. Each group was subdivided into two subgroups: without (NEP) and with (EP) induction of EP. Animals were euthanized at 3, 5 and 7 days post-treatment. Histological, histometric (percentage of bone in the furcation [PBF]) and immunohistochemical (for tumour necrosis factor-α, interleukin-1β and receptor activator of nuclear factor-κB ligand) analyses were performed. Data were statistically analysed. RESULTS:CIS-NEP and 5FU-NEP showed more inflammation than PSS-NEP at 3, 5 and 7 days. CIS-EP and 5FU-EP showed more inflammation and lower PBF than PSS-EP at all periods of evaluation. 5FU-EP showed lower PBF than CIS-EP at 5 and 7 days. CONCLUSION:5-FU and CIS exacerbated periodontal inflammation and aggravated the progression of EP in its early stages.

journal_name

J Clin Periodontol

authors

Gusman DJR,Ervolino E,Theodoro LH,Garcia VG,Nagata MJH,Alves BES,de Araujo NJ,Matheus HR,de Almeida JM

doi

10.1111/jcpe.13101

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

457-469

issue

4

eissn

0303-6979

issn

1600-051X

journal_volume

46

pub_type

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