Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2.

Abstract:

AIM:To test the hypothesis that a synthetic hydroxyapatite/β-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA/TCP construct alone. MATERIAL AND METHODS:Bilateral mandibular partial thickness 20 × 8 × 8 mm (L × W × H) alveolar defects were surgically created in the edentulated posterior mandible in 18 female minipigs. Randomized into two groups of nine animals each, the alveolar defects either received HA/TCP or HA/TCP/PEG with or without BMP-2 (105 μg/defect) in contra-lateral sites using a split-mouth design. Primary outcome, bone density (%) within four regions of interest, was evaluated following a 4-week healing interval when the animals were killed for histometric analysis. RESULTS:Bone morphogenetic proteins-2 loaded onto HA/TCP constructs significantly enhanced new bone formation compared with HA/TCP controls. Adding PEG apparently obstructed BMP-2 induced bone formation. CONCLUSION:Polyethylene glycol compromises the osteogenic effect of BMP-2.

journal_name

J Clin Periodontol

authors

Gruber RM,Krohn S,Mauth C,Dard M,Molenberg A,Lange K,Perske C,Schliephake H

doi

10.1111/jcpe.12264

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

820-6

issue

8

eissn

0303-6979

issn

1600-051X

journal_volume

41

pub_type

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