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The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial.

Abstract：

AIM:To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. MATERIAL AND METHODS:A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group). RESULTS:After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C-reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively). CONCLUSIONS:The non-surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis.

journal_name

J Clin Periodontol

journal_title

Journal of clinical periodontology

authors

Caúla AL,Lira-Junior R,Tinoco EM,Fischer RG

doi

10.1111/jcpe.12290

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

875-82

issue

9

eissn

0303-6979

issn

1600-051X

journal_volume

41

pub_type

杂志文章,随机对照试验

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