The pattern of gene expression in human CD15+ myeloid progenitor cells.

abstract：:Well-differentiated liposarcoma (WDLPS), one of the most common human sarcomas, is poorly responsive to radiation and chemotherapy, and the lack of animal models suitable for experimental analysis has seriously impeded functional investigation of its pathobiology and development of effective targeted therapies. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gutierrez A,Snyder EL,Marino-Enriquez A,Zhang YX,Sioletic S,Kozakewich E,Grebliunaite R,Ou WB,Sicinska E,Raut CP,Demetri GD,Perez-Atayde AR,Wagner AJ,Fletcher JA,Fletcher CD,Look AT

更新日期：2011-09-27 00:00:00

abstract：:Adaptive radiation is the evolution of ecological and phenotypic diversity within a rapidly multiplying lineage. Recent studies have identified general patterns in adaptive radiation and inferred that resource competition is a primary factor driving phenotypic divergence. The role and importance of other processes, su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nosil P,Crespi BJ

更新日期：2006-06-13 00:00:00

abstract：:Development of in vitro resistance to HN2 (also called mustargen or mechlorethamine hydrochloride), N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU), and cisplatin [cis-diamminedichloroplatinum(II)] was achieved in two human cell lines, the Raji/Burkitt lymphoma and a squamous cell carcinoma of the tongue. A 10- to 20-fol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frei E 3rd,Cucchi CA,Rosowsky A,Tantravahi R,Bernal S,Ervin TJ,Ruprecht RM,Haseltine WA

更新日期：1985-04-01 00:00:00

abstract：:Telomere syndromes have their most common manifestation in lung disease that is recognized as idiopathic pulmonary fibrosis and emphysema. In both conditions, there is loss of alveolar integrity, but the underlying mechanisms are not known. We tested the capacity of alveolar epithelial and stromal cells from mice with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alder JK,Barkauskas CE,Limjunyawong N,Stanley SE,Kembou F,Tuder RM,Hogan BL,Mitzner W,Armanios M

更新日期：2015-04-21 00:00:00

abstract：:The long-term viability of a forest industry in the Amazon region of Brazil depends on the maintenance of adequate timber volume and growth in healthy forests. Using extensive high-resolution satellite analyses, we studied the forest damage caused by recent logging operations and the likelihood that logged forests wou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asner GP,Broadbent EN,Oliveira PJ,Keller M,Knapp DE,Silva JN

更新日期：2006-08-22 00:00:00

abstract：:The regular spacing of somites during vertebrate embryogenesis involves a dynamic gradient of FGF signaling that controls the timing of maturation of cells in the presomitic mesoderm (PSM). How the FGF signal is transduced by PSM cells is unclear. Here, we first show that the FGF gradient is translated into graded act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delfini MC,Dubrulle J,Malapert P,Chal J,Pourquié O

更新日期：2005-08-09 00:00:00

abstract：:The relative importance of the roles of adaptation and chance in determining genetic diversity and evolution has received attention in the last 50 years, but our understanding is still incomplete. All statements about the relative effects of evolutionary factors, especially drift, need confirmation by strong demograph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiaroni J,Underhill PA,Cavalli-Sforza LL

更新日期：2009-12-01 00:00:00

abstract：:Wnt/beta-catenin signaling inhibits adipogenesis. Genome-wide profiling studies have revealed the enrichment of histone H3K27 methyltransferase Ezh2 on Wnt genes. However, the functional significance of such a direct link between the two types of developmental regulators in mammalian cells, and the role of Ezh2 in adi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Jin Q,Lee JE,Su IH,Ge K

更新日期：2010-04-20 00:00:00

abstract：:Nucleotide sequences that direct transcription of the human 5-lipoxygenase gene have been examined by ligation to the chloramphenicol acetyltransferase gene and determination of chloramphenicol acetyltransferase activity in transfected HeLa and HL-60 cells. Various lengths of 5'-flanking sequences up to 5.9 kilobase p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoshiko S,Rådmark O,Samuelsson B

更新日期：1990-12-01 00:00:00

abstract：:A fundamental issue in human development concerns how the young infant's ability to recognize emotional signals is acquired through both biological programming and learning factors. This issue is extremely difficult to investigate because of the variety of sensory experiences to which humans are exposed immediately af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pollak SD,Kistler DJ

更新日期：2002-06-25 00:00:00

abstract：:We have initiated immunological and drug-binding studies on the tubulins from different higher plant species. Antibodies were raised against electrophoretically separated rose (Rosa sp.) tubulin alpha- and beta-subunits and characterized by immunoblot autoradiographic assays. Each IgG preparation bound to its antigen ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morejohn LC,Bureau TE,Tocchi LP,Fosket DE

更新日期：1984-03-01 00:00:00

abstract：:Chronic fatigue immune dysfunction syndrome (CFIDS) is a recently recognized illness characterized by debilitating fatigue as well as immunological and neurological abnormalities [Straus, S.E. (1988) J. Inf. Dis. 157, 405-412]. Once thought to be caused by Epstein-Barr virus, it is now thought to have a different but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeFreitas E,Hilliard B,Cheney PR,Bell DS,Kiggundu E,Sankey D,Wroblewska Z,Palladino M,Woodward JP,Koprowski H

更新日期：1991-04-01 00:00:00

abstract：:A glycoprotein, termed amphiregulin (AR), inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells. It has been purified to apparent homogeneity from serum-free conditioned medium of MCF-7 human breast carcinoma cells that had been trea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shoyab M,McDonald VL,Bradley JG,Todaro GJ

更新日期：1988-09-01 00:00:00

abstract：:Murine hematopoietic blast colony-forming cells (BL-CFCs) are able to generate up to 30,000 progeny blast cells within 10 d in agar cultures. Contained in these populations are large numbers of lineage-committed progenitor cells in the granulocytic and macrophage lineages. Sequential analyses of blast colonies reveale...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metcalf D,Ng A,Mifsud S,Di Rago L

更新日期：2010-09-14 00:00:00

abstract：:Cell membrane proteins synthesized after infection of Escherichia coli B with wild-type phage T4 and rIIA mutants were analyzed by dodecyl sulfate-polyacrylamide gel electrophoresis. A protein with an approximate molecular weight of 74,000 is present in membranes isolated from T4r(+)-infected cells, but is not found i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ennis HL,Kievitt KD

更新日期：1973-05-01 00:00:00

abstract：:Increased cardiovascular mortality occurs in diabetic patients with or without coronary artery disease and is attributed to the presence of diabetic cardiomyopathy. One potential mechanism is hyperglycemia that has been reported to activate protein kinase C (PKC), preferentially the beta isoform, which has been associ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakasaki H,Koya D,Schoen FJ,Jirousek MR,Ways DK,Hoit BD,Walsh RA,King GL

更新日期：1997-08-19 00:00:00

abstract：:Immune responses can interfere with the effective use of therapeutic proteins to treat genetic deficiencies and have been challenging to manage. To address this problem, we adapted and studied methods of immune tolerance used in canine organ transplantation research to soluble protein therapeutics. A tolerization regi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kakkis E,Lester T,Yang R,Tanaka C,Anand V,Lemontt J,Peinovich M,Passage M

更新日期：2004-01-20 00:00:00

abstract：:Because it is able to produce desalinated water directly using solar energy with minimum carbon footprint, solar steam generation and desalination is considered one of the most important technologies to address the increasingly pressing global water scarcity. Despite tremendous progress in the past few years, efficien...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Xu W,Tang M,Zhou L,Zhu B,Zhu S,Zhu J

更新日期：2016-12-06 00:00:00

abstract：:Transcriptionally silent genes are maintained in inaccessible chromatin. Accessibility of these genes requires their modification by chromatin remodeling complexes (CRCs), which are recruited to promoters by sequence-specific DNA-binding proteins. Early B-cell factor (EBF), which is crucial for B-cell lineage specific...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao H,Lukin K,Ramírez J,Fields S,Lopez D,Hagman J

更新日期：2009-07-07 00:00:00

abstract：:We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones T,Federspiel NA,Chibana H,Dungan J,Kalman S,Magee BB,Newport G,Thorstenson YR,Agabian N,Magee PT,Davis RW,Scherer S

更新日期：2004-05-11 00:00:00

abstract：:August-Copenhagen-Irish (ACI) rats are unique in that the ovary-intact females develop high incidence of mammary cancers induced solely by hormones upon prolonged exposure to high levels of estrogen alone. Studies have also shown that such prolonged exposure to high-dose estrogen results in human-like aneuploid mammar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blank EW,Wong PY,Lakshmanaswamy R,Guzman R,Nandi S

更新日期：2008-03-04 00:00:00

abstract：:We have shown recently that the temporal order of antioxidant consumption in human blood plasma exposed to a constant flux of aqueous peroxyl radicals is ascorbate = protein thiols greater than bilirubin greater than urate greater than alpha-tocopherol and that detectable lipid peroxidation starts only after ascorbate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frei B,England L,Ames BN

更新日期：1989-08-01 00:00:00

abstract：:Type I and type III IFNs bind to different cell-surface receptors but induce identical signal transduction pathways, leading to the expression of antiviral host effector molecules. Despite the fact that type III IFN (IFN-λ) has been shown to predominantly act on mucosal organs, in vivo infection studies have failed to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pott J,Mahlakõiv T,Mordstein M,Duerr CU,Michiels T,Stockinger S,Staeheli P,Hornef MW

更新日期：2011-05-10 00:00:00

abstract：:We find that histidine residues in proteins are major targets for reaction with the lipid peroxidation product 4-hydroxynon-2-enal (HNE). Reaction of insulin (which contains no sulfhydryl groups) with HNE leads to the generation of HNE-protein adducts, which are converted to radioactive derivatives upon subsequent tre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchida K,Stadtman ER

更新日期：1992-05-15 00:00:00

abstract：:Lon is an ATPase associated with cellular activities (AAA+) protease that controls cell division in response to stress and also degrades misfolded and damaged proteins. Subunits of Lon are known to assemble into ring-shaped homohexamers that enclose an internal degradation chamber. Here, we demonstrate that hexamers o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vieux EF,Wohlever ML,Chen JZ,Sauer RT,Baker TA

更新日期：2013-05-28 00:00:00

abstract：:We have studied the kinetics of vitellogenin mRNA accumulation in rooster liver after a primary injection of 17beta-estradiol. The levels of vitellogenin mRNA have been determined both by hybridization of total cellular RNA to vitellogenin cDNA and by translation of vitellogenin mRNA in a wheat germ cell-free system. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burns AT,Deeley RG,Gordon JI,Udell DS,Mullinix KP,Goldberger RF

更新日期：1978-04-01 00:00:00

abstract：:Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases that have inflammation as a common underlying cause. sEH limits tissue levels of cytochrome P450 (CYP) epoxides derived from omega-6 and omega-3 polyunsaturated fatty acids (PUFA) by converting these antiinflammatory mediators in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： López-Vicario C,Alcaraz-Quiles J,García-Alonso V,Rius B,Hwang SH,Titos E,Lopategi A,Hammock BD,Arroyo V,Clària J

更新日期：2015-01-13 00:00:00

abstract：:The template-directed synthesis of a bistable donor-acceptor [2]catenane wherein both translational isomers--one in which a tetrathiafulvalene unit in a mechanically interlocked crown ether occupies the cavity of a cyclobis(paraquat-p-phenylene) ring and the other in which a 1,5-dioxynaphthalene unit in the crown ethe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Olson MA,Fang L,Benítez D,Tkatchouk E,Basu S,Basuray AN,Zhang D,Zhu D,Goddard WA,Stoddart JF

更新日期：2010-08-10 00:00:00

abstract：:Most marine organisms disperse via ocean currents as larvae, so it is often assumed that larval-stage duration is the primary determinant of geographic range size. However, empirical tests of this relationship have yielded mixed results, and alternative hypotheses have rarely been considered. Here we assess the relati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luiz OJ,Allen AP,Robertson DR,Floeter SR,Kulbicki M,Vigliola L,Becheler R,Madin JS

更新日期：2013-10-08 00:00:00

abstract：:Serial passage of simian virus 40 (SV40) at high multiplicity of infection leads to the emergence of variants with deleted, substituted, and/or duplicated DNA. Individual variants have been cloned by selective complementation with temperature sensitive SV40 mutants, or nonselectively by coinfection of cells with wild-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brockman WW,Nathans D

更新日期：1974-03-01 00:00:00