Plasticity of the superior olivary complex.

Abstract:

:The superior olivary complex (SOC) is part of the auditory brainstem of the vertebrate brain. Residing ventrally in the rhombencephalon, it receives sensory signals from both cochleae through multisynaptic pathways. Neurons of the SOC are also a target of bilateral descending projections. Ascending and descending efferents of the SOC affect the processing of auditory signals on both sides of the brainstem and in both organs of Corti. The pattern of connectivity indicates that the SOC fulfills functions of binaural signal integration serving sound localization. But whereas many of these connectional features are shared with the inferior colliculus (with the important exception of a projection to the inner ear), cellular and molecular investigations have shown that cells residing in SOC are unique in several respects. Unlike those of other auditory brainstem nuclei, they specifically express molecules known to be involved in development, plasticity, and learning (e.g., GAP-43 mRNA, specific subunits of integrin). Moreover, neurons of the SOC in adult mammals respond to various kinds of hearing impairment with the expression of plasticity-related substances (e.g., GAP-43, c-Jun, c-Fos, cytoskeletal elements), indicative of a restructuring of auditory connectivity. These observations suggest that the SOC is pivotal in the developmental and adaptive tuning of binaural processing in young and adult vertebrates.

journal_name

Microsc Res Tech

authors

Illing RB,Kraus KS,Michler SA

doi

10.1002/1097-0029(20001115)51:4<364::AID-JEMT6>3.0

keywords:

subject

Has Abstract

pub_date

2000-11-15 00:00:00

pages

364-81

issue

4

eissn

1059-910X

issn

1097-0029

pii

10.1002/1097-0029(20001115)51:4<364::AID-JEMT6>3.0

journal_volume

51

pub_type

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