Abstract:
:Isoform diversity in striated muscle is largely controlled at the level of transcription. In this review we will concentrate on studies concerning transcriptional regulation of the alkali myosin light chain 1F/3F gene. Uncoupled activity of the MLC1F and 3F promoters, together with complex patterns of transcription in developing skeletal and cardiac muscle, combine to make analysis of this gene particularly intriguing. In vitro and transgenic studies of MLC1F/3F regulatory elements have revealed an array of cis-acting modules that each drive a subset of the expression pattern of the two promoters. These cis-acting regulatory modules, including the MLC1F and 3F promoter regions and two skeletal muscle enhancers, control tissue-specificity, cell or fibre-type specificity, and the spatiotemporal regulation of gene expression, including positional information. How each of these regulatory modules acts and how their individual activites are integrated to coordinate transcription at this locus are discussed.
journal_name
Microsc Res Techjournal_title
Microscopy research and techniqueauthors
Kelly RG,Buckingham MEdoi
10.1002/1097-0029(20000915)50:6<510::AID-JEMT8>3.0keywords:
subject
Has Abstractpub_date
2000-09-15 00:00:00pages
510-21issue
6eissn
1059-910Xissn
1097-0029pii
10.1002/1097-0029(20000915)50:6<510::AID-JEMT8>3.0journal_volume
50pub_type
杂志文章,评审abstract::All termite species (Isoptera) are eusocial. These insects live in societies where the division of labor is a predominant characteristic, conditioned by the presence of castes with different morphology, ontogeny, and development. The soldier caste is unique among social insects and it is responsible for colony defense...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20365
更新日期:2006-11-01 00:00:00
abstract::We present a microscopic investigation of nanocomposite films of iron oxide (γ-Fe(2)O(3)) magnetic nanowires (NWs) aligned into polymers, formed upon evaporation of solutions of acrylate polymer/magnetic nanoparticles under magnetic field (MF). The field causes the assembly of the γ-Fe(2)O(3) nanoparticles along the d...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20848
更新日期:2010-10-01 00:00:00
abstract::Progressive multifocal leukoencephalopathy is an important viral opportunistic infection of oligodendrocytes leading to direct demyelination. Virus is likely disseminated to the brain via the blood. However, the timing of that dissemination with relationship to clinical disease is unknown. Important clues about viral ...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/jemt.1070320405
更新日期:1995-11-01 00:00:00
abstract::Cetoniinae is one of the showiest scarab groups, exhibiting bright-metallic body colors, and usually attract great attention from entomologists and amateur collectors. Larvae of Cetoniinae show dramatically diversity on morphology and living habits. Although being considered one of the best-studied groups of Scarabaei...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23594
更新日期:2021-02-01 00:00:00
abstract::Mutations in genes related to long QT syndrome (LQTS) is recognized as an independent risk of drug-induced LQTS. We previously screened a mutation F463L in a Chinese patient with LQT2, syncope, and epilepsy. Here, we planned to illustrate how F463L influences the action of dofetilide on hERG channels. F463L-hERG plasm...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23021
更新日期:2018-06-01 00:00:00
abstract::Protein-surface interactions cause the desirable effect of controlled protein adsorption onto biodevices as well as the undesirable effect of protein fouling. The key to controlling protein-surface adsorptions is to identify and quantify the main adsorption mechanisms: adsorptions that occur (1) while depositing a pro...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20954
更新日期:2011-07-01 00:00:00
abstract::Ketogenic diets (KDs) have shown beneficial effects in experimental models of neurodegeneration, designating aged individuals as possible recipients. However, few studies have investigated their consequences on aging brain. Here, late-adult rats (19 months of age) were fed for 8 weeks with two medium chain triglycerid...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20737
更新日期:2009-12-01 00:00:00
abstract::The Fragile X syndrome (FraX), which is characterized among other physical and neurologic impairments by mental retardation, is caused by the absence of the product of the FMR1 gene. The Fragile X Mental Retardation Protein (FMRP) is a member of a novel family of RNA-binding proteins. The latter includes two other pro...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/jemt.10064
更新日期:2002-05-01 00:00:00
abstract::Effects of microstructure and phase component on mechanical property of spearer propodus of mantis shrimp were investigated. The spearer propodus consisted of three layers including epicuticle (outer layer), exocuticle (middle layer), and endocuticle (inner layer). The outer layer was composed of fluorapatite, which w...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23598
更新日期:2020-09-16 00:00:00
abstract::Multifunctional involvement of actin microfilaments during viral infection has been documented in many studies. The molecular mechanism underlying this important host-virus interaction, however, remains poorly understood. We have investigated the role of actin microfilaments in the life cycle of human parainfluenza vi...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0029(19991015)47:2<114::AID-JEM
更新日期:1999-10-15 00:00:00
abstract::Samples of polyglycolic acid PGA/polycaprolactone PCL copolymer absorbable suture materials, which is called Poliglecaprone PGC copolymer suture, were thermally treated by two different processes. The first method is the direct heat exposure, from 20 to 38 °C, in the surrounding medium. Which is an environmental study...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22957
更新日期:2018-01-01 00:00:00
abstract::This study evaluated the fluoride (F) release and remineralizing potential of varnishes containing sodium fluoride (5% NaF), 5% NaF with CPP-ACP and 5% NaF with TCP in early caries lesions in primary teeth. To determine the F release at 1, 4, 6, 24, 72, and 168 hr, strips were covered with the varnishes and immersed i...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23662
更新日期:2020-12-05 00:00:00
abstract::Voltage-gated sodium channels are largely localized to the nodes of Ranvier in myelinated axons, providing the physiological basis for saltatory conduction. Studies using antisodium channel antibodies have shown that along demyelinated axons sodium channels form new distributions. The nature of this changed distributi...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0029(19960801)34:5<445::AID-JEM
更新日期:1996-08-01 00:00:00
abstract::Dystrophin-deficient muscles have repeated cycles of necrosis and regeneration, being susceptible to injury induced by muscle contractions. Some studies have demonstrated that tendons are also affected in mdx mice, based especially on the changes in biomechanical properties arising from the respective linked muscles. ...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22448
更新日期:2015-01-01 00:00:00
abstract::This report describes osteoclastic bone resorption around intraosseous fixation screws in rat and pig mandibles. These screws supported distraction devices and provided for neutral fixation following the distraction period. Progressive clinical instability of bicortical screws and radiographic and histologic evidence ...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.10376
更新日期:2003-08-15 00:00:00
abstract::The mechanical properties of healing ligaments and tendons are not comparable to those of normal tissue. To improve the quality of the ligament healing, therapeutic strategies include gene transfer or placement of mesenchymal stem cells at the healing site. Studies show that marker genes, growth factors, and antisense...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/jemt.10114
更新日期:2002-07-01 00:00:00
abstract::The tip is one of the critical factors to improve the efficiency in picking up individual DNA molecules from solid substrates based on atomic force microscope (AFM) nanomanipulation. We found that wearing AFM tips on certain solid substrates in advance to nanomanipulation operation would largely improve the pickup eff...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.21104
更新日期:2012-05-01 00:00:00
abstract::Numerous studies using morphologic techniques have demonstrated the plasticity of pulmonary epithelial cells and the requirement for complex intercellular interactions for regeneration of normal epithelium following lung injury. Recent developments in the molecular characterization of genes expressed in the lung have ...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0029(19970901)38:5<473::AID-JEM
更新日期:1997-09-01 00:00:00
abstract::Myotonic dystrophy (DM) is an inherited multisystem disorder characterized by the presence of a high polymorphic expansion of trinucleotide (CTG) repeat in the 3' untranslated region of the DM protein kinase (DMPK) gene. However, the role of myotonic dystrophy protein kinase (DMPK) has yet to be elucidated. Studies ai...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.10223
更新日期:2002-09-01 00:00:00
abstract::Several studies support the role of Western-style diet (WD) in inflammatory bowel disease (IBD). Toll-like receptors/NOD-like receptors (TLRs/NLRs) are important to maintain a healthy epithelium as well as inducing inflammation. Given that dietary factors influence IBD development, that epithelial dysfunction is thoug...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22831
更新日期:2017-06-01 00:00:00
abstract::The rapid photothermal lysis of Escherichia coli O157:H7 treated with light-triggered Janus nanomotors was visualized by Hilbert differential contrast transmission electron microscopy (HDC-TEM). The extraordinary advantage of this high-resolution microscopic technique was that it revealed the detailed ultrastructure a...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23657
更新日期:2020-11-27 00:00:00
abstract::The importance of chloride channels for the cell is demonstrated by a number of serious human diseases that are due to mutations in chloride channels. The most well-known of these diseases is cystic fibrosis. Investigations into the mechanisms of the disease and possible treatments require the study of chloride fluxes...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.10234
更新日期:2002-12-15 00:00:00
abstract::In the way of making graphene an industry-friendly material, it must be mass-produced with high-quality and reduced cost over large areas. Assisted by machine-learning techniques, rapid, nondestructive and accurate determination of large graphene sheets on SiO2 /Si substrates has been made possible in recent years by ...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23505
更新日期:2020-09-01 00:00:00
abstract::To evaluate the performance degradation of fabric drying in domestic air-vented dryer, the appearance, mechanical, and microscopic properties of the wool fabric after different drying cycles were studied. Pilling and dimensional stability tests were performed according to established international standards. Microscop...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22881
更新日期:2017-08-01 00:00:00
abstract::Biodegradable microspheres such as those made of poly-D,L-lactide (PDLLA) are widely investigated delivery systems for drugs or antigens. The aim of this study was to examine experimental conditions in order to produce PDLLA microspheres with the best properties for controlled and sustained drug delivery by the modifi...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20529
更新日期:2008-02-01 00:00:00
abstract::Brain tumor identification using magnetic resonance images (MRI) is an important research domain in the field of medical imaging. Use of computerized techniques helps the doctors for the diagnosis and treatment against brain cancer. In this article, an automated system is developed for tumor extraction and classificat...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23238
更新日期:2019-06-01 00:00:00
abstract::Actin, though highly conserved, exhibits a myriad of diverse functions, most of which ultimately depend on its intrinsic ability to rapidly assemble and disassemble filamentous structures. Many organisms synthesize multiple actin isoforms even within the same cell. Tissue-specific expression patterns and tight develop...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0029(19991001)47:1<38::AID-JEMT
更新日期:1999-10-01 00:00:00
abstract::The enzyme adenylyl cyclase (AC) plays a pivotal role in smooth muscle relaxation. Biochemical evidence suggests that AC is predominantly located in the outer layers of the myometrium; however, neither immunocytochemical nor histochemical studies have been undertaken to demonstrate the specific cellular distribution o...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0029(19980301)40:6<488::AID-JEM
更新日期:1998-03-15 00:00:00
abstract::E-cadherin and its associated cytoplasmic proteins alpha-, beta-, and gamma-catenin, play a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. Perturbation in the expression or function of any of these molecules results in loss of intercellular adhesion, with possible conseque...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0029(19981101)43:3<224::AID-JEM
更新日期:1998-11-01 00:00:00
abstract::Ribbon synapses differ from conventional chemical synapses in that they contain, within the cloud of synaptic vesicles (SV's), a specialized synaptic body, most often termed synaptic ribbon (SR). This body assumes various forms. Reconstructions reveal that what appear as rod- or ribbon-like profiles in sections are in...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0029(19961215)35:6<472::AID-JEM
更新日期:1996-12-15 00:00:00