Epithelial-mesenchymal interactions in the alteration of gene expression and morphology following lung injury.

Abstract:

:Numerous studies using morphologic techniques have demonstrated the plasticity of pulmonary epithelial cells and the requirement for complex intercellular interactions for regeneration of normal epithelium following lung injury. Recent developments in the molecular characterization of genes expressed in the lung have generated additional tools for evaluation of lung cell phenotypes and interactions. This review discusses the relationship between molecular and morphologic changes in lung cells during injury and repair. Changes in epithelial morphology and their differentiated gene products may be mediated through alterations in expression of numerous factors acting through paracrine and autocrine mechanisms. Tumor necrosis factor alpha, transforming growth factor beta, and retinoic acid, whose roles in the regulation of epithelial cell differentiation have been well documented, will be discussed in the context of normal lung development and repair from injury.

journal_name

Microsc Res Tech

authors

O'Reilly MA,Stripp BR,Pryhuber GS

doi

10.1002/(SICI)1097-0029(19970901)38:5<473::AID-JEM

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

473-9

issue

5

eissn

1059-910X

issn

1097-0029

pii

10.1002/(SICI)1097-0029(19970901)38:5<473::AID-JEM

journal_volume

38

pub_type

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