Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia.

abstract：:Inflammation is highly associated with colon carcinogenesis. Epigenetic mechanisms could play an important role in the initiation and progression of colon cancer. Curcumin, a dietary phytochemical, shows promising effects in suppressing colitis-associated colon cancer in azoxymethane-dextran sulfate sodium (AOM-DSS) m...

journal_title：Carcinogenesis

authors： Guo Y,Wu R,Gaspar JM,Sargsyan D,Su ZY,Zhang C,Gao L,Cheng D,Li W,Wang C,Yin R,Fang M,Verzi MP,Hart RP,Kong AN

更新日期：2018-05-03 00:00:00

abstract：:Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a downregulation of p21, p27(kip1) and E-cadherin and an upregulation of β-caten...

journal_title：Carcinogenesis

authors： Bi X,Pohl NM,Qian Z,Yang GR,Gou Y,Guzman G,Kajdacsy-Balla A,Iozzo RV,Yang W

更新日期：2012-02-01 00:00:00

abstract：:DNA strand breage in response to damage produced by UV (254 nm) radiation was characterized after permeabilization of diploid normal and xeroderma pigmentosum variant fibroblasts. The breakage reaction required ATP, Mg2+ and sucrose for maximal activity and was inhibited by 150 mM Na+ or K+ and 1 mM N-ethylmaleimide. ...

journal_title：Carcinogenesis

authors： Kaufmann WK,Briley LP

更新日期：1990-01-01 00:00:00

abstract：:The mapping near Kras2 of pulmonary adenoma susceptibility 1 (Pas1), a major locus affecting inherited predisposition to lung cancer in mice prompted us to test the homologous human region (12p12) for association with lung adenocarcinoma, by a population-based study. We genotyped 213 lung adenocarcinoma patients and 2...

journal_title：Carcinogenesis

authors： Manenti G,De Gregorio L,Pilotti S,Falvella FS,Incarbone M,Ravagnani F,Pierotti MA,Dragani TA

更新日期：1997-10-01 00:00:00

abstract：:The appearance of hepatocellular adenomas and carcinomas induced in rat liver with N-nitrosomorpholine is preceded by different types of preneoplastic foci consisting of phenotypically altered hepatocytes. The altered cells show changes in the activities of various enzymes including those of carbohydrate metabolism. G...

journal_title：Carcinogenesis

authors： Klimek F,Bannasch P

更新日期：1993-09-01 00:00:00

abstract：:Despite significant research, our understanding of the molecular mechanisms of Human Papilloma Virus (HPV) induced cancers remains incomplete. Majority of invasive cervical cancers are caused by high-risk HPV 16 and 18. Two potent HPV oncoproteins, E6 and E7, promote human malignancies by disrupting the activities of ...

journal_title：Carcinogenesis

authors： Chand V,John R,Jaiswal N,Johar SS,Nag A

更新日期：2014-08-01 00:00:00

abstract：:Thioredoxin-1 is a low molecular weight redox protein that protects cells against oxidant damage. Thioredoxin-1 levels are increased in the epidermal layer of sun-damaged human skin. Thioredoxin-1 levels are also increased in several human primary tumors where its expression is associated with increased tumor cell pro...

journal_title：Carcinogenesis

authors： Mustacich D,Wagner A,Williams R,Bair W,Barbercheck L,Stratton SP,Bhattacharyya AK,Powis G

更新日期：2004-10-01 00:00:00

abstract：:Telomeres maintain chromosomal stability and integrity and are crucial in carcinogenesis. Telomere length is implicated in multiple cancer risk, but the results are conflicting. Genome-wide association studies have identified several genetic loci associated with telomere length in Caucasians. However, the roles of tel...

journal_title：Carcinogenesis

authors： Du J,Zhu X,Xie C,Dai N,Gu Y,Zhu M,Wang C,Gao Y,Pan F,Ren C,Ji Y,Dai J,Ma H,Jiang Y,Chen J,Yi H,Zhao Y,Hu Z,Shen H,Jin G

更新日期：2015-09-01 00:00:00

abstract：:A line of C3H mouse fibroblasts designated CVP3SC6 (CVP) was found to be nonresponsive to the induction of morphological transformation by the polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) and its BaP-7,8-diol and BaP-diol-epoxide derivates. This cell line was, however, susceptible to BaP-induced mutation to ou...

journal_title：Carcinogenesis

authors： Gehly EB,Heidelberger C

更新日期：1982-01-01 00:00:00

abstract：:Recent evidence demonstrates the existence of diversified microbiota in the lung. However, the effect of lung carcinogenesis on the flora in lung microenvironment has yet not been well investigated. In this study, we surveyed the microbial composition and diversity in lung tumor and paired adjacent normal tissues obta...

journal_title：Carcinogenesis

authors： Mao Q,Ma W,Wang Z,Liang Y,Zhang T,Yang Y,Xia W,Jiang F,Hu J,Xu L

更新日期：2020-08-12 00:00:00

abstract：:One hundred forty-seven female Sprague-Dawley rats were divided into 5 groups and at 60 days of age were treated i.g. with 5 mg of 7,12-dimethylbenzanthracene (DMBA) suspended in 1.0 ml of sesame oil. Selenium (Se), as selenium dioxide (SeO2), was administered in the drinking water to 4 of the 5 groups (30 rats/group)...

journal_title：Carcinogenesis

authors： Welsch CW,Goodrich-Smith M,Brown CK,Greene HD,Hamel EJ

更新日期：1981-01-01 00:00:00

abstract：:Consumption of fruits and vegetables has been associated with a decrease in cancer incidence and cardiovascular disease, presumably caused by antioxidants. We designed a human intervention study to assess antioxidative and possible anti-genotoxic properties of fruit-borne antioxidants. We hypothesized that individuals...

journal_title：Carcinogenesis

authors： Wilms LC,Boots AW,de Boer VC,Maas LM,Pachen DM,Gottschalk RW,Ketelslegers HB,Godschalk RW,Haenen GR,van Schooten FJ,Kleinjans JC

更新日期：2007-08-01 00:00:00

abstract：:Remodeling or deregulation of the calcium signaling pathway is a relevant hallmark of cancer including cutaneous melanoma (CM). In this study, using data from a published genome-wide association study (GWAS) from The University of Texas M.D. Anderson Cancer Center, we assessed the role of 41,377 common single-nucleoti...

journal_title：Carcinogenesis

authors： Wang X,Liu H,Xu Y,Xie J,Zhu D,Amos CI,Fang S,Lee JE,Li X,Nan H,Song Y,Wei Q

更新日期：2019-04-29 00:00:00

abstract：:The chemopreventive effects of phenethyl isothiocyanate (PEITC) were investigated in N-nitrosobis(2-oxopropyl)-amine (BOP)-treated hamsters. Female 5-week-old Syrian golden hamsters were divided into six groups. Animals in groups 1-3, each consisting of 30 hamsters, were given BOP by two subcutaneous injections 7 days...

journal_title：Carcinogenesis

authors： Nishikawa A,Furukawa F,Uneyama C,Ikezaki S,Tanakamaru Z,Chung FL,Takahashi M,Hayashi Y

更新日期：1996-06-01 00:00:00

abstract：:Absorption, metabolism and DNA binding of 2-nitrofluorene (NF) was studied in isolated, perfused and ventilated rat lungs and in lung microsomal incubations. Comparisons were made between control animals and animals treated with beta-naphthoflavone (BNF), a 2,3,7,8-tetrachlorodibenzo(rho)dioxin (TCDD) receptor ligand ...

journal_title：Carcinogenesis

authors： Törnquist S,Möller L,Gabrielsson J,Gustafsson JA,Toftgård R

更新日期：1990-08-01 00:00:00

abstract：:Functional inactivation of BRCA1 is an important mechanism involved in breast cancer pathogenesis. Mutation is often responsible for BRCA1 inactivation in familial breast cancer, but is not responsible for the decreased levels of BRCA1 seen in a subset of sporadic breast cancer patients. To determine if aberrant cytos...

journal_title：Carcinogenesis

authors： Rice JC,Ozcelik H,Maxeiner P,Andrulis I,Futscher BW

更新日期：2000-09-01 00:00:00

abstract：:Expression of blood group-related antigens (BGRAs) A, B, H, Le(b), Le(x) and Le(y) was examined immunohistochemically in neoplastic and hyperplastic lesions induced by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters to determine a relationship between histological and biological patterns of the lesion and expression...

journal_title：Carcinogenesis

authors： Tomioka T,Fujii H,Egami H,Takiyama Y,Pour PM

更新日期：1991-03-01 00:00:00

abstract：:Liposarcoma (LS) is the most common soft-tissue sarcoma. Dedifferentiated liposarcoma (DDLS) shows more aggressive biological behavior than that of well-differentiated liposarcoma (WDLS), so advanced therapeutic agents based on molecular mechanism are urgently needed. Here we show that tissue inhibitors of metalloprot...

journal_title：Carcinogenesis

authors： Shrestha M,Ando T,Chea C,Sakamoto S,Nishisaka T,Ogawa I,Miyauchi M,Takata T

更新日期：2019-10-16 00:00:00

abstract：:It is now widely accepted that cancer is attributed to the accumulation of genetic alterations in cells. Thus, to understand the molecular mechanisms of cancer metastasis, it is indispensable to identify the genes whose alterations accumulate during cancer progression as well as the genes whose expression is responsib...

journal_title：Carcinogenesis

authors： Yokota J

更新日期：2000-03-01 00:00:00

abstract：:Base excision repair pathway may play an important role in repairing DNA damage related to Helicobacter pylori-induced inflammatory process. To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase ...

journal_title：Carcinogenesis

authors： Li WQ,Zhang L,Ma JL,Zhang Y,Li JY,Pan KF,You WC

更新日期：2009-03-01 00:00:00

abstract：:Previous reports showed that skin fibroblasts or peripheral blood lymphocytes from individuals with hereditary cancer or with a genetic disorder predisposing to cancer show an abnormally high frequency of chromatid damage after X-irradiation in G2 phase. The reproducibility of this response suggested that it could pro...

journal_title：Carcinogenesis

authors： Takai S,Price FM,Sanford KK,Tarone RE,Parshad R

更新日期：1990-08-01 00:00:00

abstract：:In light of clinical and biological evidence that bile constituents exert preventive effects against colorectal cancer, we evaluated the influence of oral bilirubin and sodium taurocholate (NaTC) on intestinal tumor formation in APC(Min/+) mice. Mice received bilirubin and/or bovine serum albumin (BSA) and NaTC in the...

journal_title：Carcinogenesis

authors： Smith DL,Keshavan P,Avissar U,Ahmed K,Zucker SD

更新日期：2010-06-01 00:00:00

abstract：:Transforming growth factors alpha and beta (TGF-alpha and TGF-beta) isolated from normal mouse kidney induced gross morphological changes in rat urothelial cells maintained in organ culture. These morphological effects are similar to those observed after long-term treatment of rat bladder organ cultures with the carci...

journal_title：Carcinogenesis

authors： Knowles MA,Hicks RM,Dave H,Harvey AE,Roberts AB,Sporn MB

更新日期：1985-04-01 00:00:00

abstract：:The nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lung adenocarcinoma through formation of DNA adducts. Our previous research on susceptibility to tobacco-induced carcinogenesis focused on benzo[a]pyrene diol epoxide (BPDE) as the in vitro mutagen for phenotype measurements ...

journal_title：Carcinogenesis

authors： Wang L,Wei Q,Shi Q,Guo Z,Qiao Y,Spitz MR

更新日期：2007-07-01 00:00:00

abstract：:The expression of human placental type glutathione S-transferase (GST-pi) was investigated in human cutaneous carcinoma in situ, that is, actinic keratosis and Bowen's disease, and compared with that in normal skin, using Northern blot and immunohistochemical analysis. In Northern blot examination, the expression of G...

journal_title：Carcinogenesis

authors： Shimizu K,Toriyama F,Zhang HM,Yoshida H

更新日期：1995-10-01 00:00:00

abstract：:Covalent binding to haemoglobin, plasma proteins and DNA was determined after intraperitoneal administration of radiolabelled diethylnitrosamine to mice. The level of alkylation of DNA in liver--the main site of activation--was found to be about two orders of magnitude higher than the level of alkylation of haemoglobi...

journal_title：Carcinogenesis

authors： Osterman-Golkar S,Bergmark E

更新日期：1988-11-01 00:00:00

abstract：:Colorectal tumors are continuously exposed to an inflammatory environment, which together with mitogenic signals sustain several cancer hallmarks. Nuclear factor-kappa B (NFκB) is a major regulator of inflammation and variation in NFκB-associated genes could potentially be used as biomarkers to identify patients with ...

journal_title：Carcinogenesis

authors： Ungerbäck J,Belenki D,Jawad ul-Hassan A,Fredrikson M,Fransén K,Elander N,Verma D,Söderkvist P

更新日期：2012-11-01 00:00:00

abstract：:DNA damage induced by tetrachlorohydroquinone (Cl(4)HQ), the quinonoid metabolite of pentachlorophenol (PCP), was investigated in human HeLa S3 tumor cells. Formation of one major and two minor DNA adducts in cells treated with Cl(4)HQ (50-300 microM) was detected by (32)P-post-labeling assay and the adducts accumulat...

journal_title：Carcinogenesis

authors： Lin PH,Nakamura J,Yamaguchi S,La DK,Upton PB,Swenberg JA

更新日期：2001-04-01 00:00:00

abstract：:The Manchester (England) Children's Tumour Registry is population-based with a high level of ascertainment. Pathologic review ensured diagnostic accuracy. Routine monitoring of annual incidence revealed a significant increase in germ cell tumours from approximately 1 per million person years to approximately 4. Analys...

journal_title：Carcinogenesis

authors： Birch JM,Marsden HB,Swindell R

更新日期：1982-01-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have identified 58 susceptibility alleles across 37 regions associated with the risk of colorectal cancer (CRC) with P < 5×10(-8) Most studies have been conducted in non-Hispanic whites and East Asians; however, the generalizability of these findings and the potential for ethnic-...

journal_title：Carcinogenesis

authors： Schmit SL,Schumacher FR,Edlund CK,Conti DV,Ihenacho U,Wan P,Van Den Berg D,Casey G,Fortini BK,Lenz HJ,Tusié-Luna T,Aguilar-Salinas CA,Moreno-Macías H,Huerta-Chagoya A,Ordóñez-Sánchez ML,Rodríguez-Guillén R,Cruz-Bautista I

更新日期：2016-06-01 00:00:00