Abstract:
BACKGROUND:The increased odds of stomach cancer among subjects with blood type A have been reported in epidemiological studies. AIM:To study the relation of family history of gastric cancer and ABO blood type with precancerous gastric lesions in a high-risk area for stomach cancer. Subjects and setting We examined 3400 adults aged 35-64 in a population-based gastric endoscopic screening in a county in China with one of the highest rates of stomach cancer in the world. METHODS:In this cross-sectional study, data on family cancer history, ABO blood type and other characteristics of the participants were obtained by interview and blood test. Responses were compared between those with the most advanced gastric lesions, dysplasia (DYS) or intestinal metaplasia (IM), versus those with chronic atrophic gastritis (CAG) or superficial gastritis (SG). RESULTS:The prevalence odds ratio (OR) for blood type A relative to other types was 1.39 (95% CI : 1.12-1.73) for DYS and 1.28 (95% CI : 1.06-1.53) for IM. The OR associated with parental history of stomach cancer was 1.88 (95% CI : 1.20-2.95) for DYS, but the numbers were too small to evaluate aggregation among siblings. The combined OR associated with blood type A and a parental of history of gastric cancer was 2.61 (95% CI : 1.59-4.30) for DYS and 1.46 (95% CI : 0.93-2.31) for IM. CONCLUSIONS:The findings suggest that genetic factors play a role in developing precancerous gastric lesions.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
You WC,Ma JL,Liu W,Gail MH,Chang YS,Zhang L,Hu YR,Fraumeni JF Jr,Xu GWkeywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
405-7issue
3eissn
0300-5771issn
1464-3685journal_volume
29pub_type
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