Expression of Eph receptors and ephrins is differentially regulated by E-cadherin.

abstract：:The sclerotome portion of the differentiating embryonic chick somite becomes infiltrated by neural crest cells prior to its dispersal towards the embryonic axis. This means that sclerotome cells explanted into culture for the purpose of examining their interactions in vitro are contaminated with a proportion of neural...

journal_title：Journal of cell science

authors： Sanders EJ,Cheung E

更新日期：1988-05-01 00:00:00

abstract：:ADP-ribosylation factors (Arfs) and ADP-ribosylation factor-like proteins (Arls) are highly conserved small GTPases that function as main regulators of vesicular trafficking and cytoskeletal reorganization. Arl1, the first identified member of the large Arl family, is an important regulator of Golgi complex structure ...

journal_title：Journal of cell science

authors： Yu CJ,Lee FJ

更新日期：2017-05-15 00:00:00

abstract：:KLP61F in Drosophila and other BimC kinesins are essential for spindle bipolarity across species; loss of BimC function generates high frequencies of monopolar spindles. Concomitant loss of Kar3 kinesin function increases the frequency of bipolar spindles although the underlying mechanism is not known. Recent studies ...

journal_title：Journal of cell science

authors： Wilson PG,Simmons R,Saighal S

更新日期：2004-10-01 00:00:00

abstract：:Cadherins are transmembrane glycoproteins involved in Ca2+-dependent cell-cell adhesion. Using L cells expressing one of three functional E-cadherin constructs, the wild-type, a chimeric molecule with alpha-catenin (EalphaC), and a tail-less one, we determined the effect of v-Src expression on E-cadherin-mediated adhe...

journal_title：Journal of cell science

authors： Ozawa M,Ohkubo T

更新日期：2001-02-01 00:00:00

abstract：:Osh6 and Osh7 are lipid transfer proteins (LTPs) that move phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM). High PS levels at the PM are key for many cellular functions. Intriguingly, Osh6 and Osh7 localize to ER-PM contact sites, although they lack membrane-targeting motifs, in...

journal_title：Journal of cell science

authors： D'Ambrosio JM,Albanèse V,Lipp NF,Fleuriot L,Debayle D,Drin G,Čopič A

更新日期：2020-06-04 00:00:00

abstract：:Gap junctions (GJs) assembled from connexin (Cx) proteins allow direct cell-cell communication. While phosphorylation is known to regulate multiple GJ functions, much less is known about the role of ubiquitin in these processes. Using ubiquitylation-type-specific antibodies and Cx43 lysine-to-arginine mutants we show ...

journal_title：Journal of cell science

authors： Kells-Andrews RM,Margraf RA,Fisher CG,Falk MM

更新日期：2018-08-09 00:00:00

abstract：:Septins have been shown to play important roles in cytokinesis in diverse organisms ranging from yeast to mammals. In this study, we show that both the unc-59 and unc-61 loci encode Caenorhabditis elegans septins. Genomic database searches indicate that unc-59 and unc-61 are probably the only septin genes in the C. el...

journal_title：Journal of cell science

authors： Nguyen TQ,Sawa H,Okano H,White JG

更新日期：2000-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that have important roles in gene regulation. We have previously reported that activin receptor-like kinase 7 (ALK7) and its ligand, Nodal, induce apoptosis in human epithelial ovarian cancer cells. In this study, we examined the regulation of ALK7 by miRNAs and demonstrate ...

journal_title：Journal of cell science

authors： Ye G,Fu G,Cui S,Zhao S,Bernaudo S,Bai Y,Ding Y,Zhang Y,Yang BB,Peng C

更新日期：2011-02-01 00:00:00

abstract：:Centaurin-alpha(1) is a phosphatidylinositol 3,4,5-trisphosphate binding protein as well as a GTPase activating protein (GAP) for the ADP-ribosylation factor (ARF) family of small GTPases. To further understand its cellular function, we screened a rat brain cDNA library using centaurin-alpha(1) as bait to identify cen...

journal_title：Journal of cell science

authors： Venkateswarlu K,Hanada T,Chishti AH

更新日期：2005-06-01 00:00:00

abstract：:To understand the molecular mechanisms underlying sorting of apical and basolateral membrane components in human intestinal epithelial cells, we have cloned the human homolog of rat syntaxin 3 and looked for its subcellular localization. Endogenous human syntaxin 3 was found to be localized at the apical membrane of c...

journal_title：Journal of cell science

authors： Delgrossi MH,Breuza L,Mirre C,Chavrier P,Le Bivic A

更新日期：1997-09-01 00:00:00

abstract：:Human SW-13 cells express the intermediate filament protein vimentin in a mosaic pattern (Hedberg, K. K. and Chen, L. B. (1986). Exp. Cell Res. 163, 509-517). We have isolated SW-13 clones that do (vim+) or do not (vim-) synthesize vimentin as analyzed using anti-intermediate filament immunofluorescence, electron micr...

journal_title：Journal of cell science

authors： Sarria AJ,Lieber JG,Nordeen SK,Evans RM

更新日期：1994-06-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) establishes life-long latent infection in hematopoietic progenitor cells and circulating monocytes in infected individuals. Myeloid differentiation coupled with immune dysregulation leads to viral reactivation, which can cause severe disease and mortality. Reactivation of latent virus requ...

journal_title：Journal of cell science

authors： Krishna BA,Wass AB,Dooley AL,O'Connor CM

更新日期：2021-01-25 00:00:00

abstract：:The semaphorin family comprises soluble and membrane-bound proteins originally identified as axonal guidance cues that function during neuronal development. Emerging evidence suggests that a subset of semaphorins, called 'immune semaphorins', function in the immune system. The class IV semaphorins Sema4D/CD100 and Sem...

journal_title：Journal of cell science

authors： Kumanogoh A,Kikutani H

更新日期：2003-09-01 00:00:00

abstract：:Regulated, programmed cell death is crucial for all multicellular organisms. Cell death is essential in many processes, including tissue sculpting during embryogenesis, development of the immune system and destruction of damaged cells. The best-studied form of programmed cell death is apoptosis, a process that require...

journal_title：Journal of cell science

authors： Tait SW,Ichim G,Green DR

更新日期：2014-05-15 00:00:00

abstract：:A glass neodymium laser was modified to make it possible to produce small lesions of 1-2 micron size with a quantitatively known amount of energy. The 1-06-micron radiation of this laser is sufficiently absorbed by water to work without the additions of dyes. Ciliary arrest in Phragmatopoma gills was produced by an am...

journal_title：Journal of cell science

authors： Rikmenspoel R,Orris SE,O'Day P

更新日期：1977-04-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival, neurite outgrowth and synaptic plasticity by activating the receptor tropomyosin receptor kinase B (TrkB, also known as NTRK2). TrkB has been shown to undergo recycling after BDNF stimulation. We have previously reported that full-l...

journal_title：Journal of cell science

authors： Sui WH,Huang SH,Wang J,Chen Q,Liu T,Chen ZY

更新日期：2015-03-15 00:00:00

abstract：:Antithrombin inhibits chemokine-induced migration of neutrophils by activating heparan sulfate proteoglycan-dependent signaling. Whether antithrombin affects migration of other types of leukocytes is not known. We investigated the effects of antithrombin on spontaneous and chemokine-triggered migration of lymphocytes ...

journal_title：Journal of cell science

authors： Kaneider NC,Reinisch CM,Dunzendorfer S,Römisch J,Wiedermann CJ

更新日期：2002-01-01 00:00:00

abstract：:Melanotransferrin (p97) is an iron-binding membrane glycoprotein with 40% homology to transferrin and lactoferrin. It was first identified on the basis of its high level of expression in melanoma cells, as compared to normal melanocytes. It is also present in many cultured cell types. In normal tissues, p97 is express...

journal_title：Journal of cell science

authors： Alemany R,Vilá MR,Francí C,Egea G,Real FX,Thomson TM

更新日期：1993-04-01 00:00:00

abstract：:An important aspect of wound healing is the recruitment of neutrophils to the site of infection or tissue injury. Lumican, an extracellular matrix component belonging to the small leucine rich proteoglycan (SLRP) family, is one of the major keratan sulfate proteoglycans (KSPGs) within the corneal stroma. Increasing ev...

journal_title：Journal of cell science

authors： Hayashi Y,Call MK,Chikama T,Liu H,Carlson EC,Sun Y,Pearlman E,Funderburgh JL,Babcock G,Liu CY,Ohashi Y,Kao WW

更新日期：2010-09-01 00:00:00

abstract：:Chromatin is no longer considered to be a static structural framework for packaging DNA within the nucleus but is instead believed to be an interactive component of DNA metabolism. The ordered assembly of chromatin produces a nucleoprotein template capable of epigenetically regulating the expression and maintenance of...

journal_title：Journal of cell science

authors： Ridgway P,Almouzni G

更新日期：2000-08-01 00:00:00

abstract：:Insect flight muscle has a large component (Tn-H) in the tropomyosin-troponin complex that is not present in vertebrate striated muscle thin filaments. Tn-H is shown by gold/Fab labelling to be present at regular intervals in insect flight muscle thin filaments. The Fab fragment of a monoclonal antibody to Tn-H was co...

journal_title：Journal of cell science

authors： Newman R,Butcher GW,Bullard B,Leonard KR

更新日期：1992-03-01 00:00:00

abstract：:During cell division, misaligned chromosomes are captured and aligned by motors before their segregation. The CENP-E motor is recruited to polar unattached kinetochores to facilitate chromosome alignment. The spindle checkpoint protein BubR1 (also known as BUB1B) has been reported as a CENP-E interacting partner, but ...

journal_title：Journal of cell science

authors： Legal T,Hayward D,Gluszek-Kustusz A,Blackburn EA,Spanos C,Rappsilber J,Gruneberg U,Welburn JPI

更新日期：2020-08-25 00:00:00

abstract：:Two monoclonal antibodies, BA16 and BA17, have been developed using a detergent-insoluble extract of human mammary epithelial organoids as immunogen. Indirect immunofluorescent staining of cultured cells showed that the component reacting with the antibodies was filamentous and the intensity of staining was stronger i...

journal_title：Journal of cell science

authors： Bartek J,Durban EM,Hallowes RC,Taylor-Papadimitriou J

更新日期：1985-04-01 00:00:00

abstract：:Monoclonal mouse hybridoma antibodies were obtained for secreted cellular fibronectin (cFn) from A8387 fibrosarcoma cells. One of them, 52-DH1 (DH), reacted exclusively with cFns but not with plasma Fns (pFns) in immunoblotting and solid-phase EIA. The DH antibody also recognized thermolysin cFn fragments and beta-gal...

journal_title：Journal of cell science

authors： Vartio T,Laitinen L,Närvänen O,Cutolo M,Thornell LE,Zardi L,Virtanen I

更新日期：1987-11-01 00:00:00

abstract：:ARF-like proteins (ARLs) are distinct group of members of the ARF family of Ras-related GTPases. Although ARLs are very similar in primary structure to ARFs, their functions remain unclear. We cloned mouse (m) and human (h) ARL5 cDNAs to characterize the protein products and their molecular properties. mARL5 mRNA was ...

journal_title：Journal of cell science

authors： Lin CY,Li CC,Huang PH,Lee FJ

更新日期：2002-12-01 00:00:00

abstract：:Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteolytic enzymes are implicated in a variety of physiological processes, such as collagen maturation, organogenesis, angiogenesis, reproduction and inflammation. Moreover, deficiency or overexpression of certain ADAMTS ...

journal_title：Journal of cell science

authors： Llamazares M,Obaya AJ,Moncada-Pazos A,Heljasvaara R,Espada J,López-Otín C,Cal S

更新日期：2007-10-15 00:00:00

abstract：:The compartmentalization of second messenger-activated protein kinases contributes to the fidelity of hormone-mediated signal transduction events. For example, the cAMP-dependent protein kinase is tethered at specific intracellular locations through association with A-kinase anchoring proteins (AKAPs). We now report t...

journal_title：Journal of cell science

authors： Kapiloff MS,Schillace RV,Westphal AM,Scott JD

更新日期：1999-08-01 00:00:00

abstract：:During cytokinesis, the central spindle, a bundle of interdigitated anti-parallel microtubules between separating chromosomes, recruits various cytokinetic regulator proteins to the cleavage region. Here, we show that the level of protein ubiquitylation is strikingly and transiently elevated in Aurora B kinase-positiv...

journal_title：Journal of cell science

authors： Mukai A,Mizuno E,Kobayashi K,Matsumoto M,Nakayama KI,Kitamura N,Komada M

更新日期：2008-04-15 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells is a pathological process that occurs during peritoneal dialysis. EMT leads to peritoneal fibrosis, ultrafiltration failure and eventually to the discontinuation of therapy. Signaling pathways involved in mesothelial EMT are thus of great inter...

journal_title：Journal of cell science

authors： Strippoli R,Benedicto I,Foronda M,Perez-Lozano ML,Sánchez-Perales S,López-Cabrera M,Del Pozo MÁ

更新日期：2010-12-15 00:00:00

abstract：:The fate of concanavalin A (Con A) bound to normal and enucleated L cells was followed at the ultrastructural level over a 20-h period. In both enucleates and normal cells the Con A is seen to be distributed in a uniform manner over the entire cell surface following a 30-min pulse with a low concentration of Con A. In...

journal_title：Journal of cell science

authors： Wise GE

更新日期：1976-12-01 00:00:00