Importance of newly generated neurons in the adult olfactory bulb for odor discrimination.

abstract：:The androgen receptor (AR) binds to androgen response elements and regulates target genes via a mechanism involving coregulators. Here we demonstrate that the AR can interact with the testicular orphan receptor-4 (TR4) and function as a repressor to down-regulate the TR4 target genes by preventing the TR4 binding to i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee YF,Shyr CR,Thin TH,Lin WJ,Chang C

更新日期：1999-12-21 00:00:00

abstract：:Hydrogenases catalyze the reversible reaction 2H(+) + 2e(-) ↔ H(2) with an equilibrium constant that is dependent on the reducing potential of electrons carried by their redox partner. To examine the possibility of increasing the photobiological production of hydrogen within cyanobacterial cultures, we expressed the [...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ducat DC,Sachdeva G,Silver PA

更新日期：2011-03-08 00:00:00

abstract：:Ciliary Neurotrophic Factor (CNTF) was first characterized as a trophic factor for motor neurons in the ciliary ganglion and spinal cord, leading to its evaluation in humans suffering from motor neuron disease. In these trials, CNTF caused unexpected and substantial weight loss, raising concerns that it might produce ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lambert PD,Anderson KD,Sleeman MW,Wong V,Tan J,Hijarunguru A,Corcoran TL,Murray JD,Thabet KE,Yancopoulos GD,Wiegand SJ

更新日期：2001-04-10 00:00:00

abstract：:We recently have shown that mice deficient for the 86-kDa component (Ku80) of the DNA-dependent protein kinase exhibit growth retardation and a profound deficiency in V(D)J (variable, diversity, and joining) recombination. These defects may be related to abnormalities in DNA metabolism that arise from the inability of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nussenzweig A,Sokol K,Burgman P,Li L,Li GC

更新日期：1997-12-09 00:00:00

abstract：:Current theoretical models of the commons assert that common-pool resources can only be managed sustainably with clearly defined boundaries around both communities and the resources that they use. In these theoretical models, open access inevitably leads to a tragedy of the commons. However, in many open-access system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moritz M,Behnke R,Beitl CM,Bliege Bird R,Chiaravalloti RM,Clark JK,Crabtree SA,Downey SS,Hamilton IM,Phang SC,Scholte P,Wilson JA

更新日期：2018-12-18 00:00:00

abstract：:The p2b domain of Rous sarcoma virus (RSV) Gag and the p6 domain of HIV-1 Gag contain late assembly (L) domains that engage the ESCRT membrane fission machinery and are essential for virus release. We now show that the PPXY-type RSV L domain specifically recruits the BAR domain protein PACSIN2 into virus-like particle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Popov S,Popova E,Inoue M,Wu Y,Göttlinger H

更新日期：2018-07-03 00:00:00

abstract：:Highly purified RNA polymerase II was found to be able to weakly recognize the initiator (Inr) present in the adenovirus IVa2 and major late promoters. The association of RNA polymerase II with the Inr was enhanced by the general transcription factors. The Inr was capable of directing the formation of a DNA-protein co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carcamo J,Buckbinder L,Reinberg D

更新日期：1991-09-15 00:00:00

abstract：:Primary HIV-1 isolates were evaluated for their sensitivity to inhibition by beta-chemokines RANTES (regulated upon activation, normal T-cell expressed and secreted), macrophage inflammatory protein 1 alpha (MIP-1 alpha), and MIP-1 beta. Virus isolates of both nonsyncytium-inducing (NSI) and syncytium-inducing (SI) bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jansson M,Popovic M,Karlsson A,Cocchi F,Rossi P,Albert J,Wigzell H

更新日期：1996-12-24 00:00:00

abstract：:The mitochondrial trifunctional protein (TFP) catalyzes three reactions in the fatty acid β-oxidation process. Mutations in the two TFP subunits cause mitochondrial trifunctional protein deficiency and acute fatty liver of pregnancy that can lead to death. Here we report a 4.2-Å cryo-electron microscopy α2β2 tetrameri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang K,Li N,Wang X,Dai J,Liu P,Wang C,Chen XW,Gao N,Xiao J

更新日期：2018-07-03 00:00:00

abstract：:Citrullinemia is an inborn error of metabolism due to deficiency of the urea cycle enzyme, argininosuccinate synthetase [L-citrulline:L-aspartate ligase (AMP-forming), EC 6.3.4.5]. The disease was first described in humans but was recently reported in dairy cattle in Australia. Here we report the nucleotide sequence o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dennis JA,Healy PJ,Beaudet AL,O'Brien WE

更新日期：1989-10-01 00:00:00

abstract：:Previous studies have shown that the helical RecA nucleoprotein filament formed on a circular single strand of DNA causes the progressive, directional transfer of a complementary strand from naked linear duplex DNA to the nucleoprotein filament, even when the duplex contains a sizable heterologous insertion. Since Rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jwang B,Radding CM

更新日期：1992-08-15 00:00:00

abstract：:Heparinase I from Flavobacterium heparinum has important uses for elucidating the complex sequence heterogeneity of heparin-like glycosaminoglycans (HLGAGs). Understanding the biological function of HLGAGs has been impaired by the limited methods for analysis of pure or mixed oligosaccharide fragments. Here, we use me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ernst S,Rhomberg AJ,Biemann K,Sasisekharan R

更新日期：1998-04-14 00:00:00

abstract：:Wnt signaling regulates many aspects of development by increasing the signaling activity of beta-catenin. Axin is a negative regulator of the Wnt signaling pathway, and it is responsible for the formation of the beta-catenin degradation complex. Genetic studies with Drosophila suggest that Axin promotes cytoplasmic lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cong F,Varmus H

更新日期：2004-03-02 00:00:00

abstract：:Analysis of the activity and structure of lower vertebrate alcohol dehydrogenases reveals that relationships between the classical liver and yeast enzymes need not be continuous. Both the ethanol activity of class I-type alcohol dehydrogenase (alcohol:NAD+ oxidoreductase, EC 1.1.1.1) and the glutathione-dependent form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danielsson O,Jörnvall H

更新日期：1992-10-01 00:00:00

abstract：:We present the first experimental evidence to our knowledge that ingroup relations attenuate core disgust and that this helps explain the ability of groups to coact. In study 1, 45 student participants smelled a sweaty t-shirt bearing the logo of another university, with either their student identity (ingroup conditio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reicher SD,Templeton A,Neville F,Ferrari L,Drury J

更新日期：2016-03-08 00:00:00

abstract：:Synthesis of the iron-storage protein ferritin is thought to be regulated at the translational level by the cytosolic content of chelatable iron. This response to iron is regulated by the iron-modulated binding to ferritin mRNAs of a repressor protein, the iron regulatory element-binding protein. From measurements mad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenstein RS,Garcia-Mayol D,Pettingell W,Munro HN

更新日期：1991-02-01 00:00:00

abstract：:The mutation spectrum induced by the widely used antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP) showed that cisDDP[d(ApG)] adducts, although they account for only 25% of the lesions formed, are approximately 5 times more mutagenic than the major GG adduct. We report the construction of vectors bearing a sin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burnouf D,Gauthier C,Chottard JC,Fuchs RP

更新日期：1990-08-01 00:00:00

abstract：:Estrogen receptor alpha (ERalpha) plays a major role in the regulation of neuroendocrine functions and behaviors by estrogens. Although the generation of ERalpha knockout mice advanced our knowledge of ERalpha functions, gene deletion using this method is global and potentially confounded by developmental consequences...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Musatov S,Chen W,Pfaff DW,Kaplitt MG,Ogawa S

更新日期：2006-07-05 00:00:00

abstract：:Embryogenesis requires the timely and coordinated activation of developmental regulators. It has been suggested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically target the repressive H3K27me3 modification play an important role in the activation of "bivalent" genes in respon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welstead GG,Creyghton MP,Bilodeau S,Cheng AW,Markoulaki S,Young RA,Jaenisch R

更新日期：2012-08-07 00:00:00

abstract：:Mature larvae of Sarcophaga argyrostoma fail to form puparia when kept in contact with water, but pupariate after having been subsequently exposed to dryness for 30 hr. They become increasingly more sensitive to injected ecdysone the longer the exposure to dry conditions. A second wet treatment halts the production of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zdarek J,Fraenkel G

更新日期：1970-09-01 00:00:00

abstract：:Populations of isogenic embryonic stem cells or clonal bacteria often exhibit extensive phenotypic heterogeneity that arises from intrinsic stochastic dynamics of cells. The phenotypic state of a cell can be transmitted epigenetically in cell division, leading to correlations in the states of cells related by descent....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hormoz S,Desprat N,Shraiman BI

更新日期：2015-05-05 00:00:00

abstract：:Goblet cell metaplasia and mucus hypersecretion are observed in many pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. However, the regulation of goblet cell differentiation remains unclear. Here, we identify a regulator of this process in an N-ethyl-N-nitrosourea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim HT,Yin W,Nakamichi Y,Panza P,Grohmann B,Buettner C,Guenther S,Ruppert C,Kobayashi Y,Guenther A,Stainier DYR

更新日期：2019-12-17 00:00:00

abstract：:Distinct subsets of thymic epithelial cells (TECs) support T-cell development and selection. Isolated TECs contain multicellular complexes that enclose many viable thymocytes. However, the functions of those TECs, termed thymic nurse cells (TNCs), are unclear and the idea that TNCs are present in vivo is questioned. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakagawa Y,Ohigashi I,Nitta T,Sakata M,Tanaka K,Murata S,Kanagawa O,Takahama Y

更新日期：2012-12-11 00:00:00

abstract：:Inflammation is a hallmark of many diseases, such as atherosclerosis, chronic obstructive pulmonary disease, arthritis, infectious diseases, and cancer. Although steroids and cyclooxygenase inhibitors are effective antiinflammatory therapeutical agents, they may cause serious side effects. Therefore, developing unique...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeon KI,Xu X,Aizawa T,Lim JH,Jono H,Kwon DS,Abe J,Berk BC,Li JD,Yan C

更新日期：2010-05-25 00:00:00

abstract：:Human hepatitis B virus genome encodes a protein, termed HBx, that is widely recognized as a transcriptional transactivator. While HBx does not directly bind cis-acting transcriptional control elements, it has been shown to associate with cellular proteins that bind DNA. Because HBx transactivated a large number of vi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qadri I,Conaway JW,Conaway RC,Schaack J,Siddiqui A

更新日期：1996-10-01 00:00:00

abstract：:A calmodulin-neomycin-resistance fusion gene was introduced into Trypanosoma brucei by electroporation, and stably transformed cell lines were obtained. In all of the transformants, the fusion gene had integrated into the host genome at the cognate locus, evidently by homologous recombination within flanking calmoduli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eid J,Sollner-Webb B

更新日期：1991-03-15 00:00:00

abstract：:The auditory cortex is critical for perceiving a sound's location. However, there is no topographic representation of acoustic space, and individual auditory cortical neurons are often broadly tuned to stimulus location. It thus remains unclear how acoustic space is represented in the mammalian cerebral cortex and how...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller LM,Recanzone GH

更新日期：2009-04-07 00:00:00

abstract：:Unconscious neural activity has been repeatedly shown to precede and potentially even influence subsequent free decisions. However, to date, such findings have been mostly restricted to simple motor choices, and despite considerable debate, there is no evidence that the outcome of more complex free decisions can be pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soon CS,He AH,Bode S,Haynes JD

更新日期：2013-04-09 00:00:00

abstract：:Most evidence supports the view that ER alpha is responsible for estrogen (ovarian estradiol, E(2))-induced proliferation in the epithelial cells of the mammary gland, but despite this, proliferating epithelial cells do not express ER alpha. We have examined this apparent paradox by studying the role of ER alpha and E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng G,Weihua Z,Warner M,Gustafsson JA

更新日期：2004-03-16 00:00:00

abstract：:Insulin activates sterol regulatory element-binding protein-1c (SREBP-1c) in liver, thereby increasing fatty acid and triglyceride synthesis. We created a line of transgenic rats that produce epitope-tagged human SREBP-1c in liver under control of the constitutive apolipoprotein E promoter/enhancer. This system allows...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen JL,Zhang Y,Bae SH,Farooqi MS,Liang G,Hammer RE,Goldstein JL,Brown MS

更新日期：2012-10-02 00:00:00