Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily.

abstract：:We previously have identified a subpopulation of contact-insensitive (CS-) cells which lacks density-dependent inhibition of cell division in primary and low-passage cultures of Syrian hamster embryonic (SHE) fibroblastic cells. Further, we have shown that the proportion of these CS- cells declines as a result of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakano S,Ueo H,Bruce SA,Ts'o PO

更新日期：1985-08-01 00:00:00

abstract：:Splice variants (SVs) of receptors for growth hormone-releasing hormone (GHRH) have been found in primary human prostate cancers and diverse human cancer cell lines. GHRH antagonists inhibit growth of various experimental human cancers, including pancreatic and colorectal, xenografted into nude mice or cultured in vit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busto R,Schally AV,Varga JL,Garcia-Fernandez MO,Groot K,Armatis P,Szepeshazi K

更新日期：2002-09-03 00:00:00

abstract：:The phosphorylation and dephosphorylation of the dihydropyridine-sensitive Ca2+ channel was studied in transverse-tubule membranes isolated from rabbit skeletal muscle. Exposure of these membranes to either the cAMP-dependent protein kinase or a Ca2+/calmodulin-dependent protein kinase resulted in a rapid phosphorylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hosey MM,Borsotto M,Lazdunski M

更新日期：1986-06-01 00:00:00

abstract：:Bacillus thuringiensis is a widely used bacterial entomopathogen producing insecticidal toxins, some of which are expressed in insect-resistant transgenic crops. Surprisingly, the killing mechanism of B. thuringiensis remains controversial. In particular, the importance of the septicemia induced by the host midgut mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caccia S,Di Lelio I,La Storia A,Marinelli A,Varricchio P,Franzetti E,Banyuls N,Tettamanti G,Casartelli M,Giordana B,Ferré J,Gigliotti S,Ercolini D,Pennacchio F

更新日期：2016-08-23 00:00:00

abstract：:While seeking a new host cell, obligate intracellular parasites, such as the protozoan Toxoplasma gondii, must be able to endure the stress of an extracellular environment. The mechanisms Toxoplasma use to remain viable while deprived of a host cell are not understood. We have previously shown that phosphorylation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joyce BR,Queener SF,Wek RC,Sullivan WJ Jr

更新日期：2010-10-05 00:00:00

abstract：:Astronomers and physicists noticed centuries ago that visual spatial resolution is higher for dark than light stimuli, but the neuronal mechanisms for this perceptual asymmetry remain unknown. Here we demonstrate that the asymmetry is caused by a neuronal nonlinearity in the early visual pathway. We show that neurons ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kremkow J,Jin J,Komban SJ,Wang Y,Lashgari R,Li X,Jansen M,Zaidi Q,Alonso JM

更新日期：2014-02-25 00:00:00

abstract：:Hapten coupled to isologous gamma globulin can substitute for anti-idiotypic antibody in the induction of neonatal chronic idiotype suppression. The immunologically suppressed animals fail to express an idiotypically defined subset of anti-hapten antibodies in later life and harbor regulatory T cells that prevent the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tokuhisa T,Rajewsky K

更新日期：1985-06-01 00:00:00

abstract：:Dopamine is believed to contribute to the degeneration of dopamine-containing neurons in the brain. However, whether dopamine affects the survival of other neuronal populations has remained unclear. Here we document that mice with persistently elevated extracellular dopamine, resulting from inactivation of the dopamin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cyr M,Beaulieu JM,Laakso A,Sotnikova TD,Yao WD,Bohn LM,Gainetdinov RR,Caron MG

更新日期：2003-09-16 00:00:00

abstract：:The productivity of aquatic ecosystems depends on the supply of limiting nutrients. The invasion of the Laurentian Great Lakes, the world's largest freshwater ecosystem, by dreissenid (zebra and quagga) mussels has dramatically altered the ecology of these lakes. A key open question is how dreissenids affect the cycli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Ianaiev V,Huff A,Zalusky J,Ozersky T,Katsev S

更新日期：2021-02-09 00:00:00

abstract：:The sequence of the cloned Bacillus amyloliquefaciens subtilisin gene suggested that this secreted serine protease is produced as a larger precursor, designated preprosubtilisin [Wells, J. A., Ferrari, E., Henner, D. J., Estell, D. A. & Chen, E. Y. (1983) Nucleic Acids Res. 11, 7911-7925]. Biochemical evidence present...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Power SD,Adams RM,Wells JA

更新日期：1986-05-01 00:00:00

abstract：:The ability of lysosomes to move within the cytoplasm is important for many cellular functions. This ability is particularly critical in neurons, which comprise vast, highly differentiated domains such as the axon and dendrites. The mechanisms that control lysosome movement in these domains, however, remain poorly und...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farías GG,Guardia CM,De Pace R,Britt DJ,Bonifacino JS

更新日期：2017-04-04 00:00:00

abstract：:Guinea pigs were immunized with liposomal model membranes containing phosphatidylethanolamine (PE) or glycerophosphorylethanolamine (GPE) derivatives in which the amino function was substituted with either dinitrophenylaminocaproyl (Dnp-Cap) or mono(p-azobenzenearsonic acid)tyrosyl (ABA-Tyr) residues. Previous studies...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kochibe N,Nicolotti RA,Davie JM,Kinsky SC

更新日期：1975-11-01 00:00:00

abstract：:Fifteen tumor-containing specimens were obtained directly from patients with small cell carcinoma of the lung and tested for their ability to grow in serum-supplemented medium and in serum-free medium supplemented with hydrocortisone, insulin, transferrin, estrogen, and selenium (HITES). The tumor cells replicated in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carney DN,Bunn PA Jr,Gazdar AF,Pagan JA,Minna JD

更新日期：1981-05-01 00:00:00

abstract：:Nerve growth factor (NGF) is a neurotrophin with the ability to exert specific effects on cells of the immune system. Human monocytes/macrophages (M/M) infected in vitro with HIV type 1 (HIV-1) are able to produce substantial levels of NGF that are associated with enhanced expression of the high-affinity NGF receptor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garaci E,Caroleo MC,Aloe L,Aquaro S,Piacentini M,Costa N,Amendola A,Micera A,Caliò R,Perno CF,Levi-Montalcini R

更新日期：1999-11-23 00:00:00

abstract：:Genetic variation in the serotonin transporter gene (SLC6A4) is associated with vulnerability to affective disorders and pharmacotherapy efficacy. We recently identified sequence polymorphisms in the common marmoset SLC6A4 repeat region (AC/C/G and CT/T/C) associated with individual differences in anxiety-like trait, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santangelo AM,Sawiak SJ,Fryer T,Hong Y,Shiba Y,Clarke HF,Riss PJ,Ferrari V,Tait R,Suckling J,Aigbirhio FI,Roberts AC

更新日期：2019-07-16 00:00:00

abstract：:Pertussis toxin, a protein composed of five different subunits (S1, S2, S3, S4, and S5), is the major virulence factor of Bordetella pertussis. We have cloned and sequenced a DNA fragment of 4.7 kilobases that contains the genes coding for the five subunits. The genes are clustered within 3.2 kilobases in the followin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicosia A,Perugini M,Franzini C,Casagli MC,Borri MG,Antoni G,Almoni M,Neri P,Ratti G,Rappuoli R

更新日期：1986-07-01 00:00:00

abstract：:Long QT syndrome (LQT) is an autosomal dominant disorder that can cause sudden death from cardiac arrhythmias. We recently discovered that mutations in HERG, a K+-channel gene, cause chromosome 7-linked LQT. Heterologous expression of HERG in Xenopus oocytes revealed that HERG current was similar to a well-characteriz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanguinetti MC,Curran ME,Spector PS,Keating MT

更新日期：1996-03-05 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) have recently joined the list of cell surface receptors that dimerize. Dimerization has been shown to alter the ligand-binding, signaling, and trafficking properties of these receptors. Recent studies have shown that GPCRs heterodimerize with closely related members, resulting in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jordan BA,Trapaidze N,Gomes I,Nivarthi R,Devi LA

更新日期：2001-01-02 00:00:00

abstract：:Staphylococcus aureus forms biofilms on indwelling medical devices using a variety of cell-surface proteins. There is growing evidence that specific homophilic interactions between these proteins represent an important mechanism of cell accumulation during biofilm formation, but the underlying molecular mechanisms are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feuillie C,Formosa-Dague C,Hays LM,Vervaeck O,Derclaye S,Brennan MP,Foster TJ,Geoghegan JA,Dufrêne YF

更新日期：2017-04-04 00:00:00

abstract：:Finding regions of the genome that are significantly recurrent in noisy data are a common but difficult problem in present day computational biology. Cores of recurrent events (CORE) is a computational approach to solving this problem that is based on a formalized notion by which "core" intervals explain the observed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krasnitz A,Sun G,Andrews P,Wigler M

更新日期：2013-06-18 00:00:00

abstract：:Incubation of sickle cells with cystamine, a thiol reagnet, resulted in the formation of an intracellular S-ethylamine derivative. The rate of the reaction was dependent upon the cystamine concentration, the temperature, and the duration of the incubation. The cystamine-treated cells demonstrated a marked inhibition o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hassan W,Beuzard Y,Rosa J

更新日期：1976-09-01 00:00:00

abstract：:Unlike other cation channels, each subunit of most transient receptor potential (TRP) channels has an additional TRP-domain helix with an invariant tryptophan immediately trailing the gate-bearing S6. Recent cryo-electron microscopy of TRP vanilloid subfamily, member 1 structures revealed that this domain is a five-tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng J,Loukin SH,Anishkin A,Kung C

更新日期：2015-03-17 00:00:00

abstract：:The explosive growth in citizen science combined with a recalcitrance on the part of mainstream science to fully embrace this data collection technique demands a rigorous examination of the factors influencing data quality and project efficacy. Patterns of contributor effort and task performance have been well reviewe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parrish JK,Jones T,Burgess HK,He Y,Fortson L,Cavalier D

更新日期：2019-02-05 00:00:00

abstract：:The threshold behavior of the transport properties of a random metal in the critical region near a metal-insulator transition is strongly affected by the measuring electromagnetic fields. In spite of the randomness, the electrical conductivity exhibits striking phase-coherent effects due to broken symmetry, which grea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillips JC

更新日期：1997-09-30 00:00:00

abstract：:The absorption spectrum of an activesite specific chromophoric acyl enzyme, sturgeon beta-(2-furyl)-acryloyl-glyceraldehyde-3-phosphate dehydrogenase, is reported. This acyl enzyme undergoes all of the catalyzed reactions characteristic of the intermediate of the physiological acyl enzyme, 3-phospho-D-glyceroyl-glycer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malhotra OP,Bernhard SA

更新日期：1973-07-01 00:00:00

abstract：:Cocaine exposure in utero causes severe alterations in the development of the central nervous system. To study the basis of these teratogenic effects in vitro, we have used cocultures of neurons and glial cells from mouse embryonic brain. Cocaine selectively affected embryonic neuronal cells, causing first a dramatic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nassogne MC,Evrard P,Courtoy PJ

更新日期：1995-11-21 00:00:00

abstract：:Canavan's disease (CD) is a fatal, hereditary disorder of CNS development that has been linked to mutations in the gene for the enzyme aspartoacylase (ASPA) (EC 3.5.1.15). ASPA acts to hydrolyze N-acetylaspartate (NAA) into l-aspartate and acetate, but the connection between ASPA deficiency and the failure of proper C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madhavarao CN,Arun P,Moffett JR,Szucs S,Surendran S,Matalon R,Garbern J,Hristova D,Johnson A,Jiang W,Namboodiri MA

更新日期：2005-04-05 00:00:00

abstract：:Aquaporin (AQP) 4 is the predominant water channel in the mammalian brain, abundantly expressed in the blood-brain and brain-cerebrospinal fluid interfaces of glial cells. Its function in cerebral water balance has implications in neuropathological disorders, including brain edema, stroke, and head injuries. The 1.8-A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho JD,Yeh R,Sandstrom A,Chorny I,Harries WE,Robbins RA,Miercke LJ,Stroud RM

更新日期：2009-05-05 00:00:00

abstract：:Neurons in the cochlear nuclei of duck embryos become responsive to tonal stimuli in an orderly spatial and temporal sequence. Cells responding to lower frequencies are recorded before those responding to higher frequencies. Auditory neurons are spatially arranged according to their characteristic frequencies, indicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Konishi M

更新日期：1973-06-01 00:00:00

abstract：:The transcription factor interferon regulatory factor 5 (IRF5) is essential for the induction of inflammatory cytokines, but the mechanism by which IRF5 is activated is not well understood. Here we present evidence that the kinase IKKβ phosphorylates and activates IRF5 in response to stimulation in several inflammator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ren J,Chen X,Chen ZJ

更新日期：2014-12-09 00:00:00