The polo-box-dependent induction of ectopic septal structures by a mammalian polo kinase, plk, in Saccharomyces cerevisiae.

abstract：:Neurons respond to sensory stimuli by altering the rate and temporal pattern of action potentials. These spike trains both encode and propagate information that guides behavior. Local inhibitory networks can affect the information encoded and propagated by neurons by altering correlations between different spike train...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giridhar S,Doiron B,Urban NN

更新日期：2011-04-05 00:00:00

abstract：:The failure to induce self-tolerance of simian virus 40 large tumor antigen (T antigen) expressed in the pancreatic beta cells of transgenic mice results in an autoimmune response against this protein and the cells that synthesize it. In every transgenic mouse with delayed onset of T-antigen expression and consequent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skowronski J,Jolicoeur C,Alpert S,Hanahan D

更新日期：1990-10-01 00:00:00

abstract：:Recent findings suggest that neurons can efficiently repair oxidatively damaged DNA, and that both DNA damage and repair are enhanced by activation of excitatory glutamate receptors. However, in pathological conditions such as ischemic stroke, excessive DNA damage can trigger the death of neurons. Oxidative DNA damage...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canugovi C,Yoon JS,Feldman NH,Croteau DL,Mattson MP,Bohr VA

更新日期：2012-09-11 00:00:00

abstract：:The human proteome contains a plethora of short linear motifs (SLiMs) that serve as binding interfaces for modular protein domains. Such interactions are crucial for signaling and other cellular processes, but are difficult to detect because of their low to moderate affinities. Here we developed a dedicated approach, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivarsson Y,Arnold R,McLaughlin M,Nim S,Joshi R,Ray D,Liu B,Teyra J,Pawson T,Moffat J,Li SS,Sidhu SS,Kim PM

更新日期：2014-02-18 00:00:00

abstract：:Human IL-10 (hIL-10) modulates critical immune and inflammatory responses by way of interactions with its high- (IL-10R1) and low-affinity (IL-10R2) cell surface receptors. Human cytomegalovirus exploits the IL-10 signaling pathway by expressing a functional viral IL-10 homolog (cmvIL-10), which shares only 27% sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones BC,Logsdon NJ,Josephson K,Cook J,Barry PA,Walter MR

更新日期：2002-07-09 00:00:00

abstract：:Two new forms of carboxypeptidase B have been isolated from spontaneously activated bovine pancreatic juice. The fully active enzymes contain an internal split at residues 92-93 and 95-96, respectively. Sequenator analysis of the amino terminal segments of the two chains of the enzyme has extended the sequence informa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeck GR,Walsh KA,Hermodson MA,Neurath H

更新日期：1971-06-01 00:00:00

abstract：:This work explores the concept that differential wave function overlap between excited states can be engineered within a molecular chromophore. The aim is to control excited state wave function symmetries, so that symmetry matches or mismatches result in differential orbital overlap and define low-energy trajectories ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oviedo PS,Baraldo LM,Cadranel A

更新日期：2021-01-26 00:00:00

abstract：:E2F is a cellular transcription factor that binds to two sites in the adenovirus E2 promoter. Previous experiments have implicated E2F in the E1A-dependent transactivation of the E2 gene since levels of active E2F increase markedly during adenovirus infection in parallel with the increase in E2 transcription, and an E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hiebert SW,Lipp M,Nevins JR

更新日期：1989-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease in which genetic risk has been mapped to HLA, but precise allelic associations have been difficult to infer due to limitations in genotyping methodology. Mapping PD risk at highest possible resolution, we performed sequencing of 11 HLA genes in 1,597 PD cases and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hollenbach JA,Norman PJ,Creary LE,Damotte V,Montero-Martin G,Caillier S,Anderson KM,Misra MK,Nemat-Gorgani N,Osoegawa K,Santaniello A,Renschen A,Marin WM,Dandekar R,Parham P,Tanner CM,Hauser SL,Fernandez-Viña M,Oksenb

更新日期：2019-04-09 00:00:00

abstract：:Males of the androdioecious species Caenorhabditis elegans are more likely to attempt to mate with and successfully inseminate C. elegans hermaphrodites that do not concurrently harbor sperm. Although a small number of genes have been implicated in this effect, the mechanism by which it arises remains unknown. In the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leighton DH,Choe A,Wu SY,Sternberg PW

更新日期：2014-12-16 00:00:00

abstract：:Growth hormone receptor (GHR) has been demonstrated to be nuclear localized both in vivo and in vitro, but the significance of this observation has remained elusive. Here we show that nuclear GHR is strongly correlated with proliferative status in vivo by using a liver regeneration model. In vitro, nuclear translocati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conway-Campbell BL,Wooh JW,Brooks AJ,Gordon D,Brown RJ,Lichanska AM,Chin HS,Barton CL,Boyle GM,Parsons PG,Jans DA,Waters MJ

更新日期：2007-08-14 00:00:00

abstract：:The sources of human germline mutations are poorly understood. Part of the difficulty is that mutations occur very rarely, and so direct pedigree-based approaches remain limited in the numbers that they can examine. To address this problem, we consider the spectrum of low-frequency variants in a dataset (Genome Aggreg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agarwal I,Przeworski M

更新日期：2019-09-03 00:00:00

abstract：:Children with reading impairments have deficits in phonological awareness, phonemic categorization, speech-in-noise perception, and psychophysical tasks such as frequency and temporal discrimination. Many of these children also exhibit abnormal encoding of speech stimuli in the auditory brainstem, even though response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hornickel J,Skoe E,Nicol T,Zecker S,Kraus N

更新日期：2009-08-04 00:00:00

abstract：:Vesicular stomatitis virus (VSV) exhibits a remarkably robust and pantropic infectivity, mediated by its coat protein, VSV-G. Using this property, recombinant forms of VSV and VSV-G-pseudotyped viral vectors are being developed for gene therapy, vaccination, and viral oncolysis and are extensively used for gene transd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finkelshtein D,Werman A,Novick D,Barak S,Rubinstein M

更新日期：2013-04-30 00:00:00

abstract：:To improve the efficiency of liposome-mediated DNA transfer as a tool for gene therapy, we have developed a fusigenic liposome vector based on principles of viral cell fusion. The fusion proteins of hemagglutinating virus of Japan (HVJ; also Sendai virus) are complexed with liposomes that encapsulate oligodeoxynucleot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dzau VJ,Mann MJ,Morishita R,Kaneda Y

更新日期：1996-10-15 00:00:00

abstract：:Tomato flavor is dependent upon a complex mixture of volatiles including multiple acetate esters. Red-fruited species of the tomato clade accumulate a relatively low content of acetate esters in comparison with the green-fruited species. We show that the difference in volatile ester content between the red- and green-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goulet C,Mageroy MH,Lam NB,Floystad A,Tieman DM,Klee HJ

更新日期：2012-11-13 00:00:00

abstract：:Cell-based therapies are attractive for revascularizing and regenerating tissues and organs, but clinical trials of endothelial progenitor cell transplantation have not resulted in consistent benefit. We propose a different approach in which a material delivery system is used to create a depot of vascular progenitor c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva EA,Kim ES,Kong HJ,Mooney DJ

更新日期：2008-09-23 00:00:00

abstract：:In both human patients and murine models, the progression from insulitis to diabetes is neither immediate nor inevitable, as illustrated by the innocuous versus destructive infiltrates of BDC2.5 transgenic mice on the nonobese diabetic (NOD) versus C57BL/6.H-2g7 genetic backgrounds. Natural killer (NK)-cell-specific t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poirot L,Benoist C,Mathis D

更新日期：2004-05-25 00:00:00

abstract：:The fluorescence properties of GFP are strongly influenced by the protonation states of its chromophore and nearby amino acid side chains. In the ground state, the GFP chromophore is neutral and absorbs in the near UV. Upon excitation, the chromophore is deprotonated, and the resulting anionic chromophore emits its gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kennis JT,Larsen DS,van Stokkum IH,Vengris M,van Thor JJ,van Grondelle R

更新日期：2004-12-28 00:00:00

abstract：:Midbrain dopamine neurons play central roles in reward processing. It is widely assumed that all dopamine neurons encode the same information. Some evidence, however, suggests functional differences between subgroups of dopamine neurons, particularly with respect to processing nonrewarding, aversive stimuli. To direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brischoux F,Chakraborty S,Brierley DI,Ungless MA

更新日期：2009-03-24 00:00:00

abstract：:Unlike parasitic protist groups that are defined by the absence of mitochondria, the Pelobiontida is composed mostly of free-living species. Because of the presence of ultrastructural and cellular features that set them apart from all other eukaryotic organisms, it has been suggested that pelobionts are primitively am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stiller JW,Duffield EC,Hall BD

更新日期：1998-09-29 00:00:00

abstract：:Gene III protein of bacteriophage f1 is inserted into the host cell membrane where it is assembled into phage particles. A truncated form of gene III protein, encoded by a recombinant plasmid and lacking the carboxyl terminus, does not remain in the membrane but instead appears to slip through it. Fusion of a hydropho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boeke JD,Model P

更新日期：1982-09-01 00:00:00

abstract：:Mapping posttranslational modifications (PTMs), which diversely modulate biological functions, represents a significant analytical challenge. The centerpiece technology for PTM site identification, mass spectrometry (MS), requires proteolytic cleavage in the vicinity of a PTM to yield peptides for sequencing. This req...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tran DT,Cavett VJ,Dang VQ,Torres HL,Paegel BM

更新日期：2016-12-20 00:00:00

abstract：:Circadian rhythms modulate many aspects of physiology. Knowledge of the molecular basis of these rhythms has exploded in the last 20 years. However, most of these data are from model organisms, and translation to clinical practice has been limited. Here, we present an approach to identify molecular rhythms in humans f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anafi RC,Francey LJ,Hogenesch JB,Kim J

更新日期：2017-05-16 00:00:00

abstract：:A Raleigh, NC, population of Drosophila melanogaster was sampled for the presence of enzyme null alleles at 25 loci. No nulls were found at any of five X-linked loci. Nulls were recovered at 13 of 20 autosomal loci; the weighted mean frequency for all 20 autosomal loci was estimated to be 0.0025. A consideration of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voelker RA,Langley CH,Brown AJ,Ohnishi S,Dickson B,Montgomery E,Smith SC

更新日期：1980-02-01 00:00:00

abstract：:Cancer stem cells (CSCs) sustain tumor growth through their ability to self-renew and to generate differentiated progeny. These functions endow CSCs with the potential to initiate secondary tumors bearing characteristics similar to those of the parent. Recently the hair follicle stem cell marker CD34 was used to purif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schober M,Fuchs E

更新日期：2011-06-28 00:00:00

abstract：:The nonneural cholinergic system of immune cells is pivotal for the maintenance of immunological homeostasis. Here we demonstrate the expression of choline acetyltransferase (ChAT) and cholinergic enzymes in murine natural killer (NK) cells. The capacity for acetylcholine synthesis by NK cells increased markedly under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang W,Li D,Han R,Zhang C,Jin WN,Wood K,Liu Q,Shi FD,Hao J

更新日期：2017-07-25 00:00:00

abstract：:The linear ubiquitin assembly complex (LUBAC) comprises 3 components: HOIP, HOIL-1, and Sharpin, of which HOIP and HOIL-1 are both members of the RBR subfamily of E3 ubiquitin ligases. HOIP catalyses the formation of Met1-linked ubiquitin oligomers (also called linear ubiquitin), but the function of the E3 ligase acti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelsall IR,Zhang J,Knebel A,Arthur JSC,Cohen P

更新日期：2019-07-02 00:00:00

abstract：:Resistance to ionizing radiation (IR), which is a conventional treatment for osteosarcoma that cannot be resected, undermines the efficacy of this therapy. However, the mechanism by which IR induces radioresistance in osteosarcoma is not defined. Here, we report that CR6-interacting factor-1 (CRIF1) is highly expresse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ran Q,Jin F,Xiang Y,Xiang L,Wang Q,Li F,Chen L,Zhang Y,Wu C,Zhou L,Xiao Y,Chen L,Wu J,Zhong JF,Li SC,Li Z

更新日期：2019-10-08 00:00:00

abstract：:A segment of DNA containing cya, the gene for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1], has been isolated from Salmonella typhimurium. The phage lambda gt4 was used as a cloning vector and adenylate cyclase-positive hybrid phages were isolated that complemented adenylate cyclase-negative bac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang JY,Clegg DO,Koshland DE Jr

更新日期：1981-08-01 00:00:00