Timescale-dependent shaping of correlation by olfactory bulb lateral inhibition.

abstract：:Recent reports on the dystrophic mouse mutant suggest that the prominent extracellular matrix component of peripheral nerve tissues plays an important role in peripheral nerve development. We have examined the disposition of two prominent extracellular matrix components, fibronectin and laminin, both in mature periphe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cornbrooks CJ,Carey DJ,McDonald JA,Timpl R,Bunge RP

更新日期：1983-06-01 00:00:00

abstract：:P/Q Ca(2+) channel activity is inhibited by G protein-coupled receptor activation. Channel inhibition requires a direct Gbetagamma binding onto the pore-forming subunit, Ca(v)2.1. It is characterized by biophysical changes, including current amplitude reduction, activation kinetic slowing, and an I-V curve shift, whic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sandoz G,Lopez-Gonzalez I,Grunwald D,Bichet D,Altafaj X,Weiss N,Ronjat M,Dupuis A,De Waard M

更新日期：2004-04-20 00:00:00

abstract：:Embryogenesis requires the timely and coordinated activation of developmental regulators. It has been suggested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically target the repressive H3K27me3 modification play an important role in the activation of "bivalent" genes in respon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welstead GG,Creyghton MP,Bilodeau S,Cheng AW,Markoulaki S,Young RA,Jaenisch R

更新日期：2012-08-07 00:00:00

abstract：:We evaluated the formation and removal of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene (BcPHDE)-DNA adducts in two Chinese hamster ovary (CHO) cell lines. One line of repair-proficient cells (MK42) carries a stable 150-fold amplification of the dihydrofolate reductase (DH...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carothers AM,Zhen W,Mucha J,Zhang YJ,Santella RM,Grunberger D,Bohr VA

更新日期：1992-12-15 00:00:00

abstract：:Message passing is a fundamental technique for performing calculations on networks and graphs with applications in physics, computer science, statistics, and machine learning, including Bayesian inference, spin models, satisfiability, graph partitioning, network epidemiology, and the calculation of matrix eigenvalues....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cantwell GT,Newman MEJ

更新日期：2019-11-19 00:00:00

abstract：:Monocytes originate from precursors made in the bone and remain in the circulation for nearly 24 h. Much effort has been done to identify the molecules regulating transendothelial migration of monocytes during inflammatory conditions. In contrast, considerably less is known about the process of constitutive monocyte e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Ecker S,Lindecke A,Hatzmann W,Kaltschmidt C,Zänker KS,Dittmar T

更新日期：2007-03-27 00:00:00

abstract：:Gonadal steroids have traditionally been found to have short-term effects on the mating behavior of adult vertebrates, such that increased steroid hormone levels influence behavior over the course of a few days. Long-term effects also have been observed in which embryonic exposure to steroid hormone influences the sex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crews D

更新日期：1991-05-01 00:00:00

abstract：:Spatial memory enhances an organism's navigational ability. Memory typically resides within the brain, but what if an organism has no brain? We show that the brainless slime mold Physarum polycephalum constructs a form of spatial memory by avoiding areas it has previously explored. This mechanism allows the slime mold...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reid CR,Latty T,Dussutour A,Beekman M

更新日期：2012-10-23 00:00:00

abstract：:Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). Here, we provide the first molecular characterization, to our knowledge, of the effect of the R258C mutation in SM α-actin, expressed wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu H,Fagnant PM,Bookwalter CS,Joel P,Trybus KM

更新日期：2015-08-04 00:00:00

abstract：:Selective autophagy of damaged mitochondria requires autophagy receptors optineurin (OPTN), NDP52 (CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to autophagic membranes. By using quantitative proteomics, we show that Tank-binding kinase 1 (TBK1) phosphorylates all four receptors on several autophagy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter B,Sliter DA,Herhaus L,Stolz A,Wang C,Beli P,Zaffagnini G,Wild P,Martens S,Wagner SA,Youle RJ,Dikic I

更新日期：2016-04-12 00:00:00

abstract：:We examine the IFN-alpha/beta-independent activation of cellular transcription that constitutes an early antiviral response of cells against influenza A and B viruses, which cause widespread epidemics in humans. We show that influenza B virus induces the synthesis in human cells of several mature mRNAs encoded by gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim MJ,Latham AG,Krug RM

更新日期：2002-07-23 00:00:00

abstract：:Among the tRNA population of the archaeal parasite Nanoarchaeum equitans are five species assembled from separate 5' and 3' tRNA halves and four species derived from tRNA precursors containing introns. In both groups an intervening sequence element must be removed during tRNA maturation. A bulge-helix-bulge (BHB) moti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randau L,Calvin K,Hall M,Yuan J,Podar M,Li H,Söll D

更新日期：2005-12-13 00:00:00

abstract：:Three enzyme reactions have been reported to catalyze the synthesis of phosphoribosylamine in eukaryotic cells. These activities are glutamine phosphoribosylpyrophosphate (P-Rib-P-P) amidotransferase [amidophosphoribosyl-transferase; 5-phosphoribosylamine: pyrophosphate phosphoribosyltransferase (glutamate-amidating) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes EW,King GL,Leyva A,Singer SC

更新日期：1976-07-01 00:00:00

abstract：:Flagellar polypeptides of Chlamydomonas reinhardtii were analyzed in two-dimensions by isoelectric focusing and electrophoresis in the presence of sodium dodecyl sulfate. In addition to flagellar tubulin, over 130 polypeptides were resolved and 100 of these were identified as axonemal components in wild-type organisms...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piperno G,Huang B,Luck DJ

更新日期：1977-04-01 00:00:00

abstract：:Heat shock protein 90-alpha (Hsp90alpha) is an intracellular molecular chaperone. However, it can also be secreted with the underlying regulatory mechanism remaining far from clear. Here we show that the secreted Hsp90alpha is a C-terminal truncated form and its secretion is regulated by the C-terminal EEVD motif via ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Song X,Zhuo W,Fu Y,Shi H,Liang Y,Tong M,Chang G,Luo Y

更新日期：2009-12-15 00:00:00

abstract：:Two adjacent, divergently transcribed, developmentally regulated genes of the maize chloroplast chromosome have different superhelical density/transcriptional activation profiles when transcribed in vitro by the homologous DNA-dependent RNA polymerase. Promoter-specific transcription of the gene for the beta and epsil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stirdivant SM,Crossland LD,Bogorad L

更新日期：1985-08-01 00:00:00

abstract：:Evidence for perceptual periodicity emerges from studies showing periodic fluctuations in visual perception and decision making that are accompanied by neural oscillations in brain activity. We have uncovered signs of periodicity in the time course of binocular rivalry, a widely studied form of multistable perception....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cha O,Blake R

更新日期：2019-07-23 00:00:00

abstract：:We study atomic models of the thermodynamics of the structural transition of peptides that form alpha-helices. The effect of sequence variation on alpha-helix formation for alanine-rich peptides, Ac-Ala21-methyl amide (A21) and Ac-A5 (AAARA)3A-methyl amide (Fs peptide), is investigated by atomic simulation studies of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： García AE,Sanbonmatsu KY

更新日期：2002-03-05 00:00:00

abstract：:There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bravo JA,Forsythe P,Chew MV,Escaravage E,Savignac HM,Dinan TG,Bienenstock J,Cryan JF

更新日期：2011-09-20 00:00:00

abstract：:Whereas amyloid-β (Aβ) accumulates in the brain of normal animals dosed with low levels of copper (Cu), the mechanism is not completely known. Cu could contribute to Aβ accumulation by altering its clearance and/or its production. Because Cu homeostasis is altered in transgenic mice overexpressing Aβ precursor protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh I,Sagare AP,Coma M,Perlmutter D,Gelein R,Bell RD,Deane RJ,Zhong E,Parisi M,Ciszewski J,Kasper RT,Deane R

更新日期：2013-09-03 00:00:00

abstract：:The intracellular localization of phytochrome was seen in dark-grown oat (Avena sativa L., cv. Garry) and rice (Oryza sativa L., cv. unknown) shoots after various light treatments using an indirect peroxidase-antiperoxidase antibody labeling method. Phytochrome is generally distributed throughout the cytoplasm in cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackenzie JM Jr,Coleman RA,Briggs WR,Pratt LH

更新日期：1975-03-01 00:00:00

abstract：:One can imagine a variety of mechanisms that should result in self-perpetuating biological states. It is generally assumed that cytosine methylation is propagated in eukaryotes by enzymes that specifically methylate hemimethylated symmetrical sites (e.g., (5')CpGGpC(5') or (5')CpNpGGpNpC(5')). Although there is wide s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Selker EU,Freitag M,Kothe GO,Margolin BS,Rountree MR,Allis CD,Tamaru H

更新日期：2002-12-10 00:00:00

abstract：:Striatal enkephalin and dynorphin opioid systems mediate reward and negative affect, respectively, relevant to addiction disorders. We examined polymorphisms of proenkephalin (PENK) and prodynorphin (PDYN) genes in relation to heroin abuse and gene expression in the human striatum and the relevance of genetic dopamine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikoshkov A,Drakenberg K,Wang X,Horvath MC,Keller E,Hurd YL

更新日期：2008-01-15 00:00:00

abstract：:Differential rates of AIDS development and/or T4 lymphocyte depletion in HIV-1-infected individuals remain unexplained. The hypothesis that qualitative differences in selection pressure in vivo may account for different rates of disease progression was addressed in nine eligible study participants from a cohort of 315...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang WK,Essex M,McLane MF,Mayer KH,Hsieh CC,Brumblay HG,Seage G,Lee TH

更新日期：1996-06-25 00:00:00

abstract：:We have isolated CaKRE9, a gene from Candida albicans, that is a functional homologue of the Saccharomyces cerevisiae KRE9 gene involved in beta-1,6-glucan synthesis. Disruption of the CaKRE9 gene in C. albicans shows that CaKre9p is required for the synthesis or assembly of this fungal polymer. Homozygous null disrup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lussier M,Sdicu AM,Shahinian S,Bussey H

更新日期：1998-08-18 00:00:00

abstract：:Measurements of submicron particles by Fourier transform infrared spectroscopy in 14 campaigns in North America, Asia, South America, and Europe were used to identify characteristic organic functional group compositions of fuel combustion, terrestrial vegetation, and ocean bubble bursting sources, each of which often ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell LM,Bahadur R,Ziemann PJ

更新日期：2011-03-01 00:00:00

abstract：:For beta-D-glucosylisophosphoramide mustard (beta-D-Glc-IPM), a new alkylating drug in which isophosphoramide mustard is stabilized, a higher selectivity and lower myelotoxicity was observed than for the currently used cytostatic ifosfamide. Because beta-D-Glc-IPM is hydrophilic and does not diffuse passively through ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veyhl M,Wagner K,Volk C,Gorboulev V,Baumgarten K,Weber WM,Schaper M,Bertram B,Wiessler M,Koepsell H

更新日期：1998-03-17 00:00:00

abstract：:We have developed three computer programs for comparisons of protein and DNA sequences. They can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequence similarity. The FASTA program is a more sensitive derivative of the FASTP program, which can be us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pearson WR,Lipman DJ

更新日期：1988-04-01 00:00:00

abstract：:Linkage analysis with restriction fragment length polymorphisms for the gene for type II procollagen (COL2A1) was carried out in a family with the Stickler syndrome, or arthro-ophthalmopathy, an autosomal dominant disorder that affects the eyes, ears, joints, and skeleton. The analysis demonstrated linkage of the dise...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahmad NN,Ala-Kokko L,Knowlton RG,Jimenez SA,Weaver EJ,Maguire JI,Tasman W,Prockop DJ

更新日期：1991-08-01 00:00:00

abstract：:We present a synthetic adaptation of the fibrillar adhesion surfaces found in nature. The structure consists of protruding fibrils topped by a thin plate and shows an experimentally measured enhancement in adhesion energy of up to a factor of 9 over a flat control. Additionally, this structure solves the robustness pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glassmaker NJ,Jagota A,Hui CY,Noderer WL,Chaudhury MK

更新日期：2007-06-26 00:00:00