Abstract:
:Oscillations in intracellular free calcium concentration ([Ca(2+)](i)) occur spontaneously in immature neurons of the developing cerebral cortex. Here, we show that developing murine cortical neurons exhibit calcium oscillations in response to direct activation of the mGluR5 subtype of the group I metabotropic glutamate receptor (mGluR). In contrast, other manipulations that elicit [Ca(2+)](i) increases produce simple, nonoscillatory changes. Furthermore, we find that spontaneous oscillatory [Ca(2+)](i) activity is blocked by antagonists of group I mGluRs, suggesting a specific role for mGluR activation in the promotion of oscillatory [Ca(2+)](i) dynamics in immature cortical neurons. The oscillatory pattern of [Ca(2+)](i) increases produced by mGluR activation might play a role in the regulation of gene expression and the control of developmental events.
journal_name
Proc Natl Acad Sci U S Aauthors
Flint AC,Dammerman RS,Kriegstein ARdoi
10.1073/pnas.96.21.12144keywords:
subject
Has Abstractpub_date
1999-10-12 00:00:00pages
12144-9issue
21eissn
0027-8424issn
1091-6490journal_volume
96pub_type
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