当前位置： SCI文献检索 > INTENSIVE CARE MEDICINE期刊下所有文献 > Time course of activated coagulation time at various sites during continuous haemodiafiltration using nafamostat mesilate.

Time course of activated coagulation time at various sites during continuous haemodiafiltration using nafamostat mesilate.

Abstract：

OBJECTIVE:To determine the adequate site of activated coagulation time (ACT) measurement during continuous haemodiafiltration (CHDF) using nafamostat mesilate. DESIGN:Prospective, consecutive, clinical study. SETTING:An intensive care unit of a general hospital. PATIENTS:Ten patients with acute organ failure including kidney, lung and liver, caused by sepsis after major surgery. INTERVENTIONS:A CHDF circuit with a haemofilter made of polymethylmethacrylate membrane was primed with 50 mg nafamostat in 500 ml saline, and was started at a circuit flow rate of 100 ml/min. Continuous injection of 0.5 mg/kg per h nafamostat, 700 ml/h of dialysis fluid and 1000 ml/h of filtrate fluid was set. MEASUREMENTS AND RESULTS:The circuit pressure at the inlet and outlet of the circuit were monitored, and ACT was measured every 2 h at the site of nafamostat injection, outlet, patient's artery and inlet until 24 h. A value of standard deviation of ACT at each site was regarded as the variation value of ACT. The circuit pressure did not change significantly. The ACT did not change significantly at any measurement site. The variation value of ACT at the inlet of the circuit was significantly lower than that at the site of nafamostat injection. CONCLUSIONS:The ACT value at the inlet of the circuit may be adequate to monitor anticoagulation during CHDF using nafamostat.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Hu ZJ,Iwama H,Suzuki R,Kobayashi S,Akutsu I

doi

10.1007/s001340050892

keywords:

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

524-7

issue

5

eissn

0342-4642

issn

1432-1238

journal_volume

25

pub_type

临床试验,杂志文章

相关文献

INTENSIVE CARE MEDICINE文献大全
  • Organophosphate poisonings with parathion and dimethoate.

    abstract：OBJECTIVE:Organophosphate toxicity is the leading cause of morbidity and death in poisoning by insecticides. The clinical symptoms of pesticide toxicity range from the classic cholinergic syndrome to flaccid paralysis and intractable seizures. The mainstays of therapy are atropine, oximes, benzodiazepines and supportiv...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-005-0051-z

    authors： Hoffmann U,Papendorf T

    更新日期：2006-03-01 00:00:00

  • Variations in pulmonary artery occlusion pressure to estimate changes in pleural pressure.

    abstract：OBJECTIVE:A readily available assessment of changes in pleural pressure would be useful for ventilator and fluid management in critically ill patients. We examined whether changes in pulmonary artery occlusion pressure (Ppao) adequately reflect respiratory changes in pleural pressure as assessed by changes in intraesop...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-007-0842-5

    authors： Bellemare P,Goldberg P,Magder SA

    更新日期：2007-11-01 00:00:00

  • Alterations of soluble L- and P-selectins during cardiac arrest and CPR.

    abstract：OBJECTIVE:To investigate the relationship between cytokines and the inflammatory responses in patients with out-of-hospital cardiac arrest, we examined the changes of cytokines as well as alterations in the markers of neutrophil activation, platelet and endothelial activation, and endothelial injury. DESIGN:Prospectiv...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章

    doi：10.1007/s001340050907

    authors： Gando S,Nanzaki S,Morimoto Y,Kobayashi S,Kemmotsu O

    更新日期：1999-06-01 00:00:00

  • Glucose and urea production and leucine, ketoisocaproate and alanine fluxes at supraphysiological plasma adrenaline concentrations in volunteers.

    abstract：OBJECTIVE:To determine the magnitude and time course of adrenergic effects on metabolism in volunteers and possible implications for the use of sympathomimetics in the critically ill. DESIGN:Descriptive laboratory investigation. SUBJECTS:7 volunteers. INTERVENTION:Primed continuous infusions of stable isotope tracer...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01707665

    authors： Ensinger H,Träger K,Geisser W,Anhäupl T,Ahnefeld FW,Vogt J,Georgieff M

    更新日期：1994-01-01 00:00:00

  • Theophylline and ethylenediamine pharmacokinetics following administration of aminophylline to septic patients with multiorgan failure.

    abstract：:The pharmacokinetics of theophylline and ethylenediamine were examined in 6 patients with septicaemia and multiorgan failure (MOF). The patients received a bolus injection of 4 mg/kg aminophylline. Aminophylline is the ethylenediamine salt of theophylline. The clearance of theophylline was reduced in all our patients ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01690768

    authors： Toft P,Heslet L,Hansen M,Klitgaard NA

    更新日期：1991-01-01 00:00:00

  • Intravenous sildenafil for postoperative pulmonary hypertension in children with congenital heart disease.

    abstract：PURPOSE:To evaluate the efficacy and safety of intravenous sildenafil for immediate postoperative pulmonary hypertension (PH) in pediatric patients undergoing congenital heart surgery. METHODS:A double-blind, multicenter, placebo-controlled, dose-ranging, parallel-group trial was conducted. Patients were randomized to...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00134-010-2065-4

    authors： Fraisse A,Butrous G,Taylor MB,Oakes M,Dilleen M,Wessel DL

    更新日期：2011-03-01 00:00:00

  • Transpulmonary gradient of type III procollagen peptides: acute effects of cardio-pulmonary bypass.

    abstract：:Type III procollagen N-peptides (PIIINPs) are believed to be released in stoichiometric amounts as type III collagen molecules are secreted from cells. We hypothesized that if the human lung actively produces type III collagen a detectable transpulmonary gradient in PIIINPs would exist in normal individuals that might...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01706477

    authors： Harrison NK,Laurent GJ,Evans TW

    更新日期：1992-01-01 00:00:00

  • Central venous catheter infections: concepts and controversies.

    abstract：:Central venous catheters (CVCs) are widely used in critically ill patients in intensive care units. However, infectious complications are common and may limit their utility. We critically review the literature to determine the impact of CVC design and composition, insertion site selection, insertion procedures, care a...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,评审

    doi：10.1007/BF01726542

    authors： Reed CR,Sessler CN,Glauser FL,Phelan BA

    更新日期：1995-02-01 00:00:00

  • Interferon gamma in trauma-related infections.

    abstract：OBJECTIVE:The efficacy of interferon gamma therapy in reducing infection and improving outcome from infection in patients sustaining major injury was examined. DESIGN:Randomized double-blind placebo control trial SETTING:Nine level one university affiliated trauma centers in the United States. PATIENTS AND PARTICIPA...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/BF01743725

    authors： Dries DJ

    更新日期：1996-10-01 00:00:00

  • Are religion and religiosity important to end-of-life decisions and patient autonomy in the ICU? The Ethicatt study.

    abstract：PURPOSE:This study explored differences in end-of-life (EOL) decisions and respect for patient autonomy of religious members versus those only affiliated to that particular religion (affiliated is a member without strong religious feelings). METHODS:In 2005 structured questionnaires regarding EOL decisions were distri...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-012-2554-8

    authors： Bülow HH,Sprung CL,Baras M,Carmel S,Svantesson M,Benbenishty J,Maia PA,Beishuizen A,Cohen S,Nalos D

    更新日期：2012-07-01 00:00:00

  • Steady-state trough serum and epithelial lining fluid concentrations of teicoplanin 12 mg/kg per day in patients with ventilator-associated pneumonia.

    abstract：OBJECTIVE:To determine the steady-state trough serum and epithelial lining fluid (ELF) concentrations of teicoplanin 12 mg/kg per day in critically ill patients with ventilator associated pneumonia. DESIGN AND SETTING:Prospective, pharmacokinetic study in the surgical intensive care unit in a university hospital. PAT...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-006-0136-3

    authors： Mimoz O,Rolland D,Adoun M,Marchand S,Breilh D,Brumpt I,Debaene B,Couet W

    更新日期：2006-05-01 00:00:00

  • Procalcitonin for discrimination between activity of systemic autoimmune disease and systemic bacterial infection.

    abstract：OBJECTIVE:To investigate whether serum procalcitonin (PCT) levels could be useful to differentiate between systemic infection and the activity of the underlying disease in autoimmune disease. METHODS:In 18 patients with systemic lupus erythematodes (SLE) and 35 patients with systemic antineutrophil cytoplasmic antibod...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF02900738

    authors： Brunkhorst R,Eberhardt OK,Haubitz M,Brunkhorst FM

    更新日期：2000-03-01 00:00:00

  • Changes of right ventricular function with positive end-expiratory pressure (PEEP) in man.

    abstract：:The side effects of positive pressure ventilation on cardiovascular function are well known. However, in most clinical studies its influence on left ventricular function was examined. In the present study right ventricular (RV) performance was studied in 13 patients undergoing coronary artery bypass grafting during me...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF00256962

    authors： Neidhart PP,Suter PM

    更新日期：1988-01-01 00:00:00

  • Physiological effects of noninvasive positive ventilation during acute moderate hypercapnic respiratory insufficiency in children.

    abstract：INTRODUCTION:A prospective physiological study was performed in 12 paediatric patients with acute moderate hypercapnic respiratory insufficiency to assess the ability of noninvasive positive pressure ventilation (NPPV) to unload the respiratory muscles and improve gas exchange. MATERIALS AND METHODS:Breathing pattern,...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00134-008-1202-9

    authors： Essouri S,Durand P,Chevret L,Haas V,Perot C,Clement A,Devictor D,Fauroux B

    更新日期：2008-12-01 00:00:00

  • Serum free cortisol index, free cortisol, and total cortisol in critically ill children.

    abstract：BACKGROUND:In critical illness, serum total cortisol (TC) may not adequately reflect adrenal function because of reduced cortisol-binding globulin (CBG). AIM:To evaluate adrenal function of critically ill children, using free cortisol index (FCI), calculated free cortisol (cFC), and TC levels. METHODS:Thirty-two crit...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-009-1480-x

    authors： Poomthavorn P,Lertbunrian R,Preutthipan A,Sriphrapradang A,Khlairit P,Mahachoklertwattana P

    更新日期：2009-07-01 00:00:00

  • ARDS caused by herpes simplex virus pneumonia in a patient with Crohn's disease: a case report.

    abstract：:Pneumonia caused by herpes simplex virus type 1 (HSV1) is rare and occurs in severely immunosuppressed patients. HSV1 can be detected in bronchoalveolar lavage (BAL) from patients presenting with respiratory failure, but its direct effect on disease is difficult to prove. We demonstrate the causative role of HSV1 in t...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340050339

    authors： François-Dufresne A,Garbino J,Ricou B,Wunderli W

    更新日期：1997-03-01 00:00:00

  • Bolus remifentanil for chest drain removal in ICU: a randomized double-blind comparison of three modes of analgesia in post-cardiac surgical patients.

    abstract：PURPOSE:We compared 1 versus 0.5 microg/kg bolus remifentanil versus placebo in alleviating pain due to chest drain removal. Effects on sedation, respiratory rate (RR), oxygen saturation, heart rate (HR) and blood pressure were also evaluated. METHODS:Sixty patients following cardiac surgery were enrolled in this pros...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00134-010-1836-2

    authors： Casey E,Lane A,Kuriakose D,McGeary S,Hayes N,Phelan D,Buggy D

    更新日期：2010-08-01 00:00:00

  • Online vs live methods for teaching difficult airway management to anesthesiology residents.

    abstract：OBJECTIVE:To compare the effectiveness of traditional and online teaching methods for educating anesthesiology residents in the principles and practice of difficult airway management. DESIGN:Prospective, randomized, controlled trial. SETTING:University hospital. PARTICIPANTS:Two randomly selected groups, each contai...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00134-005-2561-0

    authors： Bello G,Pennisi MA,Maviglia R,Maggiore SM,Bocci MG,Montini L,Antonelli M

    更新日期：2005-04-01 00:00:00

  • Evaluation of a simple method for minimizing iatrogenic blood loss from discard volumes in critically ill newborns and children.

    abstract：OBJECTIVE:To validate a simple method avoiding discard volumes in pediatric patients with indwelling arterial and venous lines. DESIGN:Zero-discarding was achieved by passive extracorporeal arteriovenous backflow via standard single pressure transducer equipment. We tested backflow distances (10, 20 and 30 cm beyond t...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s001340100951

    authors： Weiss M,Fischer J,Boeckmann M,Rohrer B,Baenziger O

    更新日期：2001-06-01 00:00:00

  • Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines.

    abstract：PURPOSE:To provide evidence-based guidelines for early enteral nutrition (EEN) during critical illness. METHODS:We aimed to compare EEN vs. early parenteral nutrition (PN) and vs. delayed EN. We defined "early" EN as EN started within 48 h independent of type or amount. We listed, a priori, conditions in which EN is o...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,meta分析,实务指引,评审

    doi：10.1007/s00134-016-4665-0

    authors： Reintam Blaser A,Starkopf J,Alhazzani W,Berger MM,Casaer MP,Deane AM,Fruhwald S,Hiesmayr M,Ichai C,Jakob SM,Loudet CI,Malbrain ML,Montejo González JC,Paugam-Burtz C,Poeze M,Preiser JC,Singer P,van Zanten AR,De Waele J

    更新日期：2017-03-01 00:00:00

  • The CRIB (Clinical Risk Index for Babies) score and neurodevelopmental impairment at one year corrected age in very low birth weight infants.

    abstract：OBJECTIVE:To assess the ability of the Clinical Risk Index for Babies (CRIB) to predict long-term neurodevelopmental impairment in very low birth weight (VLBW) infants. DESIGN:Single-center cohort study. SETTING:Tertiary neonatal care hospital and follow-up clinic. PATIENTS:Four hundred fifty-five VLBW infants conse...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340051157

    authors： Bührer C,Grimmer I,Metze B,Obladen M

    更新日期：2000-03-01 00:00:00

  • Association between tidal volume size, duration of ventilation, and sedation needs in patients without acute respiratory distress syndrome: an individual patient data meta-analysis.

    abstract：PURPOSE:Mechanical ventilation with lower tidal volumes (≤6 ml/kg of predicted body weight, PBW) could benefit patients without acute respiratory distress syndrome (ARDS). However, tidal volume reduction could be associated with increased patient discomfort and sedation needs, and consequent longer duration of ventilat...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00134-014-3318-4

    authors： Serpa Neto A,Simonis FD,Barbas CS,Biehl M,Determann RM,Elmer J,Friedman G,Gajic O,Goldstein JN,Horn J,Juffermans NP,Linko R,de Oliveira RP,Sundar S,Talmor D,Wolthuis EK,de Abreu MG,Pelosi P,Schultz MJ

    更新日期：2014-07-01 00:00:00

  • Acquired von Willebrand syndrome in patients with extracorporeal life support (ECLS).

    abstract：PURPOSE:Extracorporeal life support (ECLS) is used for patients with refractory heart failure with or without respiratory failure. This temporary support is provided by blood pumps which are connected to large vessels. Bleeding episodes are a typical complication in patients with ECLS. Recently, several studies illustr...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-011-2370-6

    authors： Heilmann C,Geisen U,Beyersdorf F,Nakamura L,Benk C,Trummer G,Berchtold-Herz M,Schlensak C,Zieger B

    更新日期：2012-01-01 00:00:00

  • Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy.

    abstract：PURPOSE:Septic shock-induced disseminated intravascular coagulopathy (DIC) contributes to multiple organ failure. Mechanisms governing vascular responses to open occurrence of DIC have not yet been established. Circulating plasma microparticles (MPs), released upon cell stress, constitute a catalytic procoagulant surfa...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s00134-013-2993-x

    authors： Delabranche X,Boisramé-Helms J,Asfar P,Berger A,Mootien Y,Lavigne T,Grunebaum L,Lanza F,Gachet C,Freyssinet JM,Toti F,Meziani F

    更新日期：2013-10-01 00:00:00

  • Monitoring of neuromuscular blockade: a comparison of train-of-four and the Campbell diagram.

    abstract：: ...

    journal_title：Intensive care medicine

    pub_type： 信件

    doi：10.1007/s00134-018-5420-5

    authors： Baedorf Kassis E,Train S,MacNeil B,Loring SH,Talmor D

    更新日期：2018-12-01 00:00:00

  • The relationship between methodological trial quality and the effects of impregnated central venous catheters.

    abstract：OBJECTIVE:We assessed the methodological trial quality of individual randomized controlled studies on chlorhexidine silver sulfadiazine impregnated catheters and the effect on catheter-related infection (CRI). DESIGN:Only the studies identified in the Medline database from 1966 to December 2001 were considered, abstra...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00134-003-1646-x

    authors： Geffers C,Zuschneid I,Eckmanns T,Rüden H,Gastmeier P

    更新日期：2003-03-01 00:00:00

  • Multinational development and validation of an early prediction model for delirium in ICU patients.

    abstract：RATIONALE:Delirium incidence in intensive care unit (ICU) patients is high and associated with poor outcome. Identification of high-risk patients may facilitate its prevention. PURPOSE:To develop and validate a model based on data available at ICU admission to predict delirium development during a patient's complete I...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00134-015-3777-2

    authors： Wassenaar A,van den Boogaard M,van Achterberg T,Slooter AJ,Kuiper MA,Hoogendoorn ME,Simons KS,Maseda E,Pinto N,Jones C,Luetz A,Schandl A,Verbrugghe W,Aitken LM,van Haren FM,Donders AR,Schoonhoven L,Pickkers P

    更新日期：2015-06-01 00:00:00

  • Influenza vaccination and 1-year risk of myocardial infarction, stroke, heart failure, pneumonia, and mortality among intensive care unit survivors aged 65 years or older: a nationwide population-based cohort study.

    abstract：PURPOSE:We examined whether influenza vaccination affects 1-year risk of myocardial infarction, stroke, heart failure, pneumonia, and death among intensive care unit (ICU) survivors aged ≥ 65 years. METHODS:Danish Intensive Care Database data on all elderly ( ≥ 65 years) patients hospitalized in Danish ICUs in the per...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-019-05648-4

    authors： Christiansen CF,Thomsen RW,Schmidt M,Pedersen L,Sørensen HT

    更新日期：2019-07-01 00:00:00

  • Role of replacement fluids in the immediate complications of plasma exchange. French Registry Cooperative Group.

    abstract：OBJECTIVE:Comparison of side effects (fever shivering and/or allergic reactions, collapse, symptomatic hypocalcaemia) of the different substitution fluids used during therapeutical plasmapheresis. DESIGN:Multicentric retrospective comparative study designed to explore the side effects due to the replacements fluids (a...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s001340050595

    authors： Korach JM,Berger P,Giraud C,Le Perff-Desman C,Chillet P

    更新日期：1998-05-01 00:00:00

  • Central venous to mixed venous blood oxygen and lactate gradients are associated with outcome in critically ill patients.

    abstract：OBJECTIVE:Blood O(2) saturation and lactate concentration gradients from superior vena cava (SVC) to pulmonary artery (PA) occur in critically ill patients. These gradients (DeltaSO(2) and Delta[Lac]) may be positive or negative. We tested the hypothesis that positive DeltaSO(2) and Delta[Lac] are associated with impro...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00134-008-1128-2

    authors： Gutierrez G,Comignani P,Huespe L,Hurtado FJ,Dubin A,Jha V,Arzani Y,Lazzeri S,Sosa L,Riva J,Kohn W,Suarez D,Lacuesta G,Olmos D,Mizdraji C,Ojeda A

    更新日期：2008-09-01 00:00:00