Vascular endothelial growth factor in reproductive biology.

Abstract:

:The critical role of angiogenesis in embryology and tumor biology has been recognized for more than 20 years. However, the fact that neovascularization is essential to processes in mammalian female reproduction has only recently been appreciated widely. In this review we focus on a single angiogenic growth factor, vascular endothelial growth factor. As scientists have discovered in many aspects of cell biology, multiple and redundant signaling pathways have evolved in nature, presumably to protect essential biological functions from inactivating diseases or mutations. Despite this redundancy, some factors are of hierarchical importance. Vascular endothelial growth factor appears to be such a factor in the regulation of angiogenesis.

authors

Lebovic DI,Mueller MD,Taylor RN

doi

10.1097/00001703-199906000-00004

keywords:

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

255-60

issue

3

eissn

1040-872X

issn

1473-656X

journal_volume

11

pub_type

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