Impact of follicle stimulating hormone receptor variants in fertility.

Abstract:

PURPOSE OF REVIEW:Genetic variation plays a crucial role in modification of normal or disease pathophysiology. Follicle stimulating hormone receptor (FSHR) signaling is necessary for normal development and function of the ovaries and testes. Here, we review the associations between FSHR polymorphisms and fertility or subfertility. RECENT FINDINGS:FSHR polymorphisms consist of single nucleotide changes within the coding and regulatory regions and/or alternatively spliced products. Most of the investigations focused on two single nucleotide polymorphisms (SNPs) in the coding region of the receptor, which result in amino acid changes (p.307Thr/Ala, p.680Asn/Ser). In women, these SNPs were associated with variable response to ovarian stimulation with FSH during infertility treatment. Not all studies revealed an association, and those that did showed a small effect. Alternative splice variants of the receptor affecting the extracellular domain without causing a frameshift have been found in women undergoing ovarian stimulation, and in infertile men. Associations with polycystic ovary syndrome, premature ovarian failure, osteoporosis, and cancer found small effect. SUMMARY:The identification of FSHR variants in a select infertility patient population has significant clinical implications in demonstrating a possible genetic cause to female infertility and improves our understanding of the genetic basis of infertility as a whole. Pharmacogenomics is a new field aiming to devise individualized treatments for disorders based on the genetic signature of the patients.

authors

Lalioti MD

doi

10.1097/GCO.0b013e3283455288

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

158-67

issue

3

eissn

1040-872X

issn

1473-656X

journal_volume

23

pub_type

杂志文章,评审
  • Adolescents with perinatally acquired HIV: emerging behavioral and health needs for long-term survivors.

    abstract:PURPOSE OF REVIEW:Because of widespread availability of highly active antiretroviral therapy in the developed world, a large proportion of children with perinatally acquired HIV have survived to adolescence and young adulthood. Although their survival is remarkable, many now experience the long-term effects of HIV infe...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e32834a581b

    authors: Koenig LJ,Nesheim S,Abramowitz S

    更新日期:2011-10-01 00:00:00

  • Modern management of vulvar cancer.

    abstract:PURPOSE OF REVIEW:The radical surgical approach in the treatment of vulvar cancer patients has led to a favourable prognosis for the majority of patients with early stage vulvar cancer. However, morbidity is impressive, leading to more individualized treatment. The authors have reviewed the most recent literature on th...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200402000-00012

    authors: de Hullu JA,Oonk MH,van der Zee AG

    更新日期:2004-02-01 00:00:00

  • Digital media and sexually transmitted infections.

    abstract:PURPOSE OF REVIEW:Digital media, including the Internet, social networking sites, text messaging, and mobile applications, are ubiquitous among adolescents and young adults. These platforms enable users to obtain important information on a multitude of health topics, they may facilitate risk-taking behaviors, and they ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000104

    authors: Gilliam M,Chor J,Hill B

    更新日期:2014-10-01 00:00:00

  • The effect of oral contraceptives on assisted reproductive technology [corrected] cycles.

    abstract:PURPOSE OF REVIEW:To summarize the available data regarding the value of oral contraceptive pill addition in ovarian stimulation schemes used for in-vitro fertilization. RECENT FINDINGS:In agonists cycles, a decreased incidence of ovarian cyst formation is expected in patients pretreated with the oral contraceptive pi...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e3280bad868

    authors: Kolibianakis EM,Venetis CA,Tarlatzis BC

    更新日期:2007-06-01 00:00:00

  • Managing the toxicities of the aromatase inhibitors.

    abstract:PURPOSE OF REVIEW:The aromatase inhibitors are increasingly used as adjuvant therapy in postmenopausal women with hormone receptor positive breast cancer. With additional experience using these agents, unanticipated side effects have become apparent. Women who experience side effects from adjuvant endocrine therapy are...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e328334e44e

    authors: Mortimer JE

    更新日期:2010-02-01 00:00:00

  • New developments in diagnosis and management of adolescents with sexually transmitted disease.

    abstract::The battle against the epidemic of sexually transmitted infections continues but the clinician has new diagnostic and therapeutic weapons. This manuscript reviews new technologies, as well as novel applications of newer methodologies, such as utilization of amplified DNA techniques for urine specimens or patient-colle...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-199910000-00006

    authors: Biro FM

    更新日期:1999-10-01 00:00:00

  • Treatment potential of bone marrow-derived stem cells in women with diminished ovarian reserves and premature ovarian failure.

    abstract:PURPOSE OF REVIEW:We review the techniques recently tested in both animal models and humans to provide a state-of-the-art on adult stem cell ovarian transplant to achieve ovarian rejuvenation in patients with diminished ovarian reserves. RECENT FINDINGS:As the firsts reports of spontaneous pregnancies achieved after b...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000531

    authors: Herraiz S,Pellicer N,Romeu M,Pellicer A

    更新日期:2019-06-01 00:00:00

  • Pelvic relaxation involving the middle compartment.

    abstract::Loss of pelvic support involving the 'middle compartment' is manifested by herniation through the central pelvic floor in proximity to the intersection of an imaginary line from the public symphysis to the coccyx with another from one ischial spine to opposite ischial spine. Loss of middle compartment support may exis...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Timmons MC,Addison WA

    更新日期:1993-08-01 00:00:00

  • Old wine into new wineskins: an update for female stress urinary incontinence.

    abstract:PURPOSE OF REVIEW:To review minimally invasive modifications of traditional surgeries for female stress urinary incontinence (SUI) in light of increased demand. RECENT FINDINGS:Prior to the synthetic mid-urethral sling (MUS), traditional procedures were used to correct SUI. Often these were retropubic colposuspension ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000579

    authors: Shaw JS

    更新日期:2019-12-01 00:00:00

  • Outcome of laparoscopic colorectal resection for endometriosis.

    abstract:PURPOSE OF REVIEW:Endometriosis is a frequent gynaecological disorder in young women. Colorectal endometriosis accounts for about 90% of all intestinal locations. The effectiveness of medical therapies is poor, and surgery, including colorectal resection, is therefore often required. Since the first description of lapa...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e328216f6bc

    authors: Daraï E,Bazot M,Rouzier R,Houry S,Dubernard G

    更新日期:2007-08-01 00:00:00

  • Biomarkers that may predict response to immunotherapy in ovarian malignancies.

    abstract:PURPOSE OF REVIEW:Immune checkpoint blockade (ICB) is a promising area of cancer therapeutic research. Therapies targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) mechanism of tumor immune evasion have resulted in durable responses in many difficult-to-treat tumor types. While these...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章

    doi:10.1097/GCO.0000000000000596

    authors: Chin CD,Fares CM,Konecny GE,Rao J

    更新日期:2020-02-01 00:00:00

  • Aromatase inhibition for ovarian stimulation: future avenues for infertility management.

    abstract::Ovarian stimulation is applied during infertility management either alone or in conjunction with intrauterine insemination and assisted reproductive technologies. At the present time, the two main medications used for ovarian stimulation include an oral antiestrogen, clomiphene citrate, and injectable gonadotropins. I...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200206000-00003

    authors: Mitwally MF,Casper RF

    更新日期:2002-06-01 00:00:00

  • Vascular endothelial growth factor expression in the endometrium during the menstrual cycle, implantation window and early pregnancy.

    abstract:PURPOSE OF REVIEW:The review aims to summarize recent data about vascular endothelial growth factor and its implications in the normal endometrium during the menstrual cycle, implantation window and early pregnancy. RECENT FINDINGS:Angiogenesis is crucial for the development of endometrium as well as for embryo implan...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.gco.0000175362.12470.e0

    authors: Nardo LG

    更新日期:2005-08-01 00:00:00

  • Ovarian pathology.

    abstract::During the period under review (December 1990 through January 1992), the revised World Health Organization Histological Classification of Ovarian Neoplasms and Tumor-like Lesions was completed, and it is presented herein. This system of classification incorporates recent advances and includes newly recognized entities...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Talerman A

    更新日期:1992-08-01 00:00:00

  • Contemporary prediction of preeclampsia.

    abstract:PURPOSE OF REVIEW:To provide a concise review of advances in prediction of preeclampsia, highlighting the most important and interesting articles among the many published within the past months, making a clear distinction between early and late clinical forms of the condition. RECENT FINDINGS:The performance of matern...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e328344579c

    authors: Scazzocchio E,Figueras F

    更新日期:2011-04-01 00:00:00

  • Ureteral stents and retrograde studies: a primer for the gynecologist.

    abstract:PURPOSE OF REVIEW:To review basic techniques and recent advances in endourology for the practicing gynecologist. RECENT FINDINGS:New ureteral stent designs are available to improve comfort and reduce some of the complications of indwelling ureteral stents. A large prospective study failed to show a significant benefit...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e32832fd23a

    authors: Aungst MJ,Sears CL,Fischer JR

    更新日期:2009-10-01 00:00:00

  • Prognostic and predictive markers for adjuvant therapy.

    abstract:PURPOSE OF REVIEW:To avoid both overtreatment and undertreatment accurate risk assessment is mandatory. The present review gives an overview of recently published articles covering prognostic and predictive factors for adjuvant therapy in early breast cancer. RECENT FINDINGS:Gene expression signatures enhance prognost...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章

    doi:10.1097/GCO.0000000000000594

    authors: Schmidt M

    更新日期:2020-02-01 00:00:00

  • Current controversies in traditional and expanded carrier screening.

    abstract:PURPOSE OF REVIEW:Expanded carrier screening, which detects carriers for a large number of autosomal recessive and X-linked diseases, is increasing in clinical utilization. A recent joint statement from multiple professional societies, in addition to a growing literature base, offers perspective on rationale, decision ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000256

    authors: Lazarin GA,Goldberg JD

    更新日期:2016-04-01 00:00:00

  • Fertility, IVF and reproductive genetics.

    abstract:PURPOSE OF REVIEW:Telomere attrition and dysfunction has become a well established pathway involved in organismal aging, not only because it imposes a limitation to cell division and therefore, tissue regeneration but also because telomere homeostasis influences other pathways involved in aging. However, the implicatio...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000456

    authors: Varela E,Sánchez-de-Puerta I,García-Velasco JA

    更新日期:2018-06-01 00:00:00

  • Thromboembolism in pregnancy.

    abstract:PURPOSE OF REVIEW:Venous thromboembolism is the leading cause of maternal death in the UK. Thrombophilia underlies many thrombotic disorders in pregnancy. The high prevalence of thrombophilic defects in the population, the association of defects with venous thromboembolism and the special considerations for management ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.gco.0000162177.30607.59

    authors: Robertson L,Greer I

    更新日期:2005-04-01 00:00:00

  • Severe virilization in a postmenopausal woman.

    abstract::Virilization occurring in the postmenopausal woman may be either adrenal or ovarian in origin. We describe the case of a 74-year-old postmenopausal woman with severe virilization and a serum testosterone level elevated into the male range who was found to have a non-malignant aetiology for her condition. ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章

    doi:

    authors: Conn JJ,Conway GS

    更新日期:1996-10-01 00:00:00

  • Should we consider telomere length and telomerase activity in male factor infertility?

    abstract:PURPOSE OF REVIEW:The purpose of this review is to analyze what is known to date about the relation between telomeres and male fertility, and if it is possible for telomeres, or elements related to them, to be used as new prognostic biomarkers in fertility treatment. RECENT FINDINGS:Cells in germ series, including spe...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000451

    authors: Balmori C,Varela E

    更新日期:2018-06-01 00:00:00

  • Use of the levonorgestrel-releasing intrauterine system: an Austrian perspective.

    abstract::Approximately 12 million women worldwide use the levonorgestrel-releasing intrauterine system (IUS), with approximately 180,000 users of this IUS currently reported in Austria. A patient satisfaction study of 591 women in Austria revealed a high number of 'very satisfied' (79%) and 'satisfied' (19%) patients. Reliabil...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.gco.0000361658.98177.59

    authors: Concin H,Bösch H,Hintermüller P,Hohlweg T,Mursch-Edlmayr G,Pinnisch B,Schmidl-Amann S,Schulz-Greinwald G,Unterlerchner D,Wagner T,Mattle V,Wildt L,Fiala C

    更新日期:2009-11-01 00:00:00

  • Medications in pregnancy.

    abstract::Chronic medical problems and the various medications available to treat them represent an enormous volume of information for the practicing obstetrician. The agents commonly encountered are reviewed here and current literature is explored, where available, including the literature on folates in pregnancy. ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Colie CF

    更新日期:1996-12-01 00:00:00

  • Tumor markers and molecular biological markers in gynecologic malignancies.

    abstract::Gynecologic oncology is a rapidly growing field due to constant advances in immunohistochemistry and molecular biology. This review serves as an overview of new studies promoting the use of tumor markers and molecular biological prognostic factors in malignancies affecting women. The majority of studies focus on eithe...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200102000-00005

    authors: Geisler JP,Geisler HE

    更新日期:2001-02-01 00:00:00

  • Voiding dysfunction in women.

    abstract::Voiding disorders are frequently associated with urinary incontinence and other lower urinary tract dysfunction in women, but the cause of these disorders is not well understood and treatment options are limited. Little has changed in the treatment and evaluation of voiding disorders. New approaches to the study of de...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Stevenson KR

    更新日期:1996-10-01 00:00:00

  • Is gonadotropin stimulation bad for oocytes?

    abstract:PURPOSE OF REVIEW:Gonadotrophin in IVF increases the number of oocytes retrieved, and many doctors regard a high number of oocytes as a measurement of success in IVF. Thus, the dogma of more oocytes provides better IVF success has been broadly accepted. However, some European fertility specialists have argued against t...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000460

    authors: Lindenberg S,Almind GJ,Lindenberg FB

    更新日期:2018-06-01 00:00:00

  • Autoimmunity and premature ovarian failure.

    abstract:PURPOSE OF REVIEW:The different patterns of autoreactivity that may account for the premature infertility observed in patients with premature ovarian failure are described. RECENT FINDINGS:Animal model studies have detailed fundamental immune dysregulatory patterns that induce ovarian failure in the context of global ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e328220e90c

    authors: Tuohy VK,Altuntas CZ

    更新日期:2007-08-01 00:00:00

  • Recurrent miscarriage: pathophysiology and outcome.

    abstract:PURPOSE OF REVIEW:This article reviews new concepts in the aetiology of recurrent miscarriage, presents new outcome data and evaluates new modalities of treatment for unexplained recurrent miscarriage. RECENT FINDINGS:Preimplantation genetic diagnosis has been considered an option for couples who have structural chrom...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.gco.0000194112.86051.26

    authors: Carrington B,Sacks G,Regan L

    更新日期:2005-12-01 00:00:00

  • Current insights in obstetric antiphospholipid syndrome.

    abstract:PURPOSE OF REVIEW:Antiphospholipid syndrome (APS) is defined as the association of thrombotic events and/or obstetric morbidity in patients persistently positive for antiphospholipid antibodies (aPL). In this review, we will highlight the most important clinical presentations of APS with a focus on the obstetric morbid...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000406

    authors: Schreiber K,Radin M,Sciascia S

    更新日期:2017-12-01 00:00:00