Abstract:
BACKGROUND:To identify which clinical factors can modify the probability of the appearance of the psychotic syndromes in patients with idiopathic Parkinson's disease treated with levodopa. PATIENTS AND METHODS:214 patients were retrospectively studied to evaluate the appearance of hallucinosis, delusions or mental confusion, from the beginning of the treatment with levodopa to a transversal evaluation along the course of the disease. To determine which clinical factors were independent predictors of psychosis, a multivariate logistic regression model was obtained, using the variables for which the univariate studies showed p values under 0.25. RESULTS:The multivariate model showed that the probability of developing psychosis during levodopa treatment was higher for the patients with intermediate or advanced stages of the disease (Hoehn and Yarh scale), at the beginning of the treatment (OR: 4.5; 95% CI: 1.86-11.23), when amantadine was administrated as associated drug (OR: 3.31; 95% CI: 1.19-9.23) and for the patients who presented motor fluctuations (OR: 3.08; 95% CI: 1.32-7.16). Univariate studies showed a significant association between levodopa psychosis and dyskinesias (univariate OR: 2.44; 95% CI: 1.12-5.33). Patients who suffered from psychotic complications had received significantly higher mean levodopa daily dose (p = 0.016) and the punctuation reached in the Folstein's Mini-Mental Scale was significantly lower (p = 0.0001). CONCLUSIONS:Levodopa psychosis appears in a "bad prognostic" group of patients, characterized by a greater motor and cognitive impairment and by the occurrence of other levodopa central adverse effects, higher doses of levodopa and a more frequent administration of other antiparkinsonian drugs.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
García-Escrig M,Bermejo Pareja F,Fernández Ponsatí JTkeywords:
subject
Has Abstractpub_date
1999-02-27 00:00:00pages
245-50issue
7eissn
0025-7753issn
1578-8989journal_volume
112pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract:INTRODUCTION AND OBJECTIVE:To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with la...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2017.02.025
更新日期:2017-10-11 00:00:00
abstract::The case of a 31 year-old intravenous drug addict female patient with infection by the human immunodeficiency virus who had recurrent cardiac tamponade and who was diagnosed by pericardic biopsy as Kaposi's sarcoma is reported. The patient demonstrated involvement by cutaneous, mucosal, lymph node and probably pleurop...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1994-04-09 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To establish the seroprevalence of infection by Borrelia burgdorferi in Navarre (Spain). PATIENTS AND METHOD:Serum samples of 1,429 individuals considered representative of the population of Navarre were analyzed. The individuals were recruited from a list issued by the government of Navarre. ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2010.06.008
更新日期:2011-03-26 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Hypertension is highly prevalent in the very elderly. We studied control rates of hypertension according to clinic blood pressure (BP) and ambulatory BP monitoring (ABPM) in treated hypertensives aged > or =80 years. PATIENTS AND METHOD:Data came from the Spanish Society of Hypertension ABPM R...
journal_title:Medicina clinica
pub_type: 杂志文章,多中心研究
doi:10.1016/j.medcli.2009.04.056
更新日期:2009-11-28 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To determine the accuracy of clinical gestalt to identify patients with acute symptomatic pulmonary embolism (PE) at low-risk for short-term complications. PATIENTS AND METHODS:This study included a total of 154 consecutive patients diagnosed with acute symptomatic PE in a tertiary university ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2017.11.023
更新日期:2018-08-22 00:00:00
abstract:BACKGROUND:Few reports have analysed the transmission of tuberculosis in rural areas with a low incidence of disease. PATIENTS AND METHOD:A population-based molecular epidemiological study of patients with tuberculosis, diagnosed by culture, was conducted in Segovia (Spain) between 1995 and 1999. Clinical, demographic...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(02)72484-6
更新日期:2002-05-11 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The REACH Registry is the largest worldwide designed to obtain information on cardiovascular risk factor control and preventive treatment in a population who have, or are at risk of having, symptoms of atherothrombosis. The objective of this study is to show the results of cardiovascular events...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2008.11.033
更新日期:2009-04-18 00:00:00
abstract:BACKGROUND:To evaluate the efficacy of methotrexate in patients with systemic lupus erythematosus (SLE) without major organ involvement resistant to medium-high doses of prednisone. METHODS:Crossover, open clinical trial with two treatment periods, the first of 3 months and the second of 6 months, an intermediate cont...
journal_title:Medicina clinica
pub_type: 临床试验,杂志文章
doi:
更新日期:1993-10-02 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The management of cardiac ischemic patients differs depending on their comorbidity. The Charlson Index (ChI) and its adaptations are well established and widely used tools to quantify a patient comorbidity. The aim of this study is to evaluate the influence of comorbidity quantified by the ChI ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13073218
更新日期:2005-04-02 00:00:00
abstract:BACKGROUND:Human obesity is a widespread disease with considerable variability as to its severity, metabolic and endocrine manifestations and etiology. In the present study we have determined whether the alterations of uncomplicated severe obesity in adult young women affect with different intensity the circulating lev...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(01)71815-5
更新日期:2001-03-10 00:00:00
abstract::The prevalence of anorexia nervosa has increased in recent years and a large proportion of patients with this disorder have low bone density at diagnosis and, therefore, an increased risk of early and late fractures. The mechanism of bone loss in anorexia nervosa is not well understood, yet it likely includes hypogona...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2009.04.046
更新日期:2010-07-17 00:00:00
abstract::The gastric emptying of solids was evaluated with radionuclide techniques in 16 patients with reflux esophagitis, demonstrated by two of the following methods: endoscopy, pathology, and/or pH measurement. The percentage of radionuclide remaining within the stomach was 80.8 +/- 17% after 45 minutes, 63.3 +/- 10% after ...
journal_title:Medicina clinica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-09-30 00:00:00
abstract::We performed a systematic review to assess the efficacy and safety of extracorporeal albumin dialysis systems in patients with liver failure. After screening 436 references, 10 controlled trials were detected. The analyzed interventions were MARS, Prometheus and Biologic-DT. Efficacy was proven by a reduction in bilir...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2010.01.032
更新日期:2011-04-23 00:00:00
abstract:OBJECTIVE:To assess the compliance, tolerance and efficacy of a short chemoprophylaxis regimen (IR) for tuberculosis using isoniazid (INH) plus rifampin (RIF) during 3 months versus a standard regimen (I) of isoniazid during 12 months in HIV positive patients. MATERIAL AND METHODS:Prospective, comparative, randomized ...
journal_title:Medicina clinica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0025-7753(00)71496-5
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Outbreaks of nosocomial infection by methicillin resistent Staphylococcus aureus (MRSA) are a problem in many hospitals with the control measures to be adopted being controversial. An outbreak of MRSA in a 550-bed university hospital is herein described and the impact of the adopted control measures on the e...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1997-03-22 00:00:00
abstract:BACKGROUND:Increasing attention has been given to the care to elderly patients in emergency departments (ED). Moreover, few data are available about final phase of the process, that is hospital admission from ED. This study was conducted to establish appropriateness, reasons and social factors related to hospital admis...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1994-10-15 00:00:00
abstract::Tumor necrosis factor (TNF) alpha plays a central role in both the inflammatory response and that of the immune system. Thus, its blockade with the so-called anti-TNF agents (infliximab, etanercept and adalimumab) represents an important tool for the management of a variety of disorders, such as rheumatoid arthritis, ...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1157/13126958
更新日期:2008-10-11 00:00:00
abstract::Several heritable disorders of glucose transport across cellular membranes have been recently characterized both genetically and pathophysiologically. Diseases such as glucose-galactose malabsorption, Fanconi-Bickel syndrome and GLUT1 deficiency syndrome are caused by mutation of transporters located in bowel, liver a...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13095099
更新日期:2006-11-11 00:00:00
abstract::A prospective, open and uncontrolled study of effectiveness and side effects of intravenous 6-methylprednisolone megadoses was carried out in 20 patients with systemic vasculitis with rapidly progressive renal failure. The results showed a favorable response of renal function in 80% of patients and a control of pulmon...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::The plasma level of neuron-specific enolase (NSE) was measured in 55 patients with small cell bronchial carcinoma (SCC) with cytohistological confirmation to evaluate its diagnostic usefulness. As a control group, 132 patients with non-small cell bronchial carcinoma, 81 with non-neoplastic disease and 37 healthy indiv...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1990-06-02 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Acute myeloid leukemia (AML) is the most frequent type of acute leukemia in adults. Despite recent advances in the characterization of pathogenesis of AML, the cure rates are under 40%, being leukemia relapse the most common cause of treatment failure. Leukaemia relapse occurs due to clonal evo...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2016.05.015
更新日期:2016-09-02 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The early detection of inborn errors of metabolism by mass spectrometry allows expanding the traditional neonatal screening of phenylketonuria and congenital hypothyroidism to test for aminoacidopathies, fatty acid oxidation disorders and organic acid metabolic disorders. Cystic fibrosis and bi...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2011.10.007
更新日期:2012-12-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) consists of an excessive depositing of fat in the liver, which can end up by causing inflammation, fibrosis and also cirrhosis with the corresponding complications including liver cancer. NAFLD has become the most common liver disease worldwide. The incidence has increased in ...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2017.06.026
更新日期:2017-12-20 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Obesity is characterized by a generalized increase of adipose tissue, high production of adipocytokines and presence of oxidative systemic stress. The objective of this study was to evaluate the changes generated in the oxidative stress and anthropometric parameters in obese subjects by the pre...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2013.12.015
更新日期:2015-07-06 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The description of different forms of PSA has opened a new strategy in the diagnosis of prostate cancer. The measurement of the ratio between free PSA and PSA in the group of patients with a PSA level between 4 and 10 ng/ml decreases the number of negative biopsies. The aim of our study was to ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(04)75311-7
更新日期:2004-02-28 00:00:00
abstract:BACKGROUND AND OBJECTIVE:There is a bidirectional association between neoplasia and venous thromboembolism (VTE). However, whether this association has an impact in tumor recurrence is unknown. The aim of the study is to assess the incidence of cancer recurrence after diagnosis of VTE and determine if VTE could be a ma...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2009.04.054
更新日期:2009-10-17 00:00:00
abstract:BACKGROUND AND OBJECTIVE:An important input to decision-making and health planning is a consistent and comparative description of the population health status. The purpose of this study was to describe the burden of disease in the Region of Valencia (Spain). MATERIAL AND METHODS:Disability-adjusted life years (DALYs) ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2012.01.028
更新日期:2013-04-20 00:00:00
abstract::The dual antiplatelet therapy with acetylsalicylic acid and clopidogrel has been the mainstay of both acute and chronic phase coronary artery disease, reducing importantly the risk of adverse events. Despite a correct compliance, a non-negligible rate of adverse events still happens. New compounds, with improved prope...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2013.12.006
更新日期:2014-12-09 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Since at present several diagnostic criteria of the metabolic syndrome (MS) exist, the objective of the study is to verify the utility of the criteria of the International Diabetes Federation (IDF) to diagnose the MS, their agreement with other previous definitions and the insulin resistance (I...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13111806
更新日期:2007-11-03 00:00:00
abstract::Twenty-six episodes of Pseudomonas aeruginosa bacteremia treated with intravenous ceftazidime, 4-6 g/day were evaluated. Treatment was begun within the first 24 hours after the isolation of the microorganism and was maintained for 10-12 days. In two patients with neutropenia amikacin was added during the initial 48-72...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1989-09-16 00:00:00