Abstract:
BACKGROUND:Outbreaks of nosocomial infection by methicillin resistent Staphylococcus aureus (MRSA) are a problem in many hospitals with the control measures to be adopted being controversial. An outbreak of MRSA in a 550-bed university hospital is herein described and the impact of the adopted control measures on the evolution of the epidemic in the general hospitalization area (GHA) was analyzed. PATIENTS AND METHODS:The adopted control measures in the GHA were: microbiologic surveillance, cutaneous isolation measures, treatment of nasal carrier, and the early discharge of the cases. Hand washing was reinforced and a study of carriers was carried out on detection of sporadic cases (not related to the ICU). A molecular study of 70 strains of MRSA was performed with analysis of total plasmids, plasmid restriction pattern and chromosomic DNA analysis by pulsed field gel electrophoresis (PFGE). RESULTS:From December 1990 to December 1993, 273 cases of MRSA were reported. One hundred seventy-two cases originated in the ICU and 101 cases in the GHA (sporadic cases). The incidence of MRSA in 1991-1993 was 13.6, 14.3, and 6.6% in the ICU and 0.17, 0.36, and 0.15% in the GHA, respectively. Molecular study of MRSA isolates (1991 and 1992) demonstrated two plasmid and two chromosomic patterns. The latter had a similarity coefficient > 0.90, probably belonging to the same "clone". CONCLUSIONS:Despite the control measures adopted in the GHA the outbreak of MRSA originated in the ICU thereafter extending to the GHA. The rates of colonization detected, however, remained stable during the 3 years studied. On the other hand, the observation of a single "clone", responsible for the epidemic, suggest that most of the sporadic cases were autoctonous and due to failure in fulfillment of the established norms.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Sopena N,Sabrià M,Pedro-Botet ML,Giménez M,Esteve M,Caraballo M,Mesalles Esubject
Has Abstractpub_date
1997-03-22 00:00:00pages
401-4issue
11eissn
0025-7753issn
1578-8989journal_volume
108pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract:BACKGROUND:The aim of the present was to study the prevalence of infection and tuberculous disease as well as the fulfillment of secondary antituberculin chemoprophylaxis in immigrants according to their geographic origin. PATIENTS AND METHODS:A descriptive study was carried out of 1,489 immigrants under the age of 35...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1996-04-13 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Dengue is the most common imported arbovirus infection in Europe. International travel and an increasing incidence of dengue fever in tropical areas have defined the disease as an emerging infection in returning travellers. We describe the clinical and microbiological features of imported dengu...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13123037
更新日期:2008-06-07 00:00:00
abstract:BACKGROUND AND OBJECTIVE:We intended to know the degree of agreement between the quality of life's perception of patients with home nutritional support and that of their main caregiver in the different dimensions. We also aimed to establish the predictive ability of the health-related quality of life (HRQL) punctuation...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(08)72258-9
更新日期:2008-09-13 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The smoke fume, principal factor in the development of lung cancer, causes the expression of certain cytokines, including interleukin 4, 6, 8 and 10, which may act by inhibiting apoptosis and interfere cellular repair mechanisms and angiogenesis. To determine the possible relationship between g...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2013.07.034
更新日期:2014-08-04 00:00:00
abstract::Alcohol causes different hematologic alterations on each of the three bone marrow cellular series. Its effect on the red series leads to the appearance of megaloblastic disturbances, erythroblastic vacuolization, iron metabolism abnormalities, and hemolytic syndromes. Megaloblastic disturbances may arise as a conseque...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1979-02-25 00:00:00
abstract:BACKGROUND:The handling of upper gastrointestinal hemorrhage (UGH) usually includes the hospitalization of all patients, regardless of severity and prognosis. The aim of this paper is to assess the security of the outpatient control of some UGH, after their assessment in the hospital emergency room. PATIENTS AND METHO...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Although smoking habit is a well-known cardiovascular risk factor, it has been described that smokers admitted because of myocardial infarction have better prognosis than non smoker patients, which is known as "the smoking paradox". The purpose of our work is to investigate whether this phenome...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2010.01.039
更新日期:2011-02-19 00:00:00
abstract:BACKGROUND:To analyze the relationship between length of hospitalary stay and early readmission rate. To assess the hypothesis that those admissions with the lowest length of stay are associated with higher early readmission rate. PATIENTS AND METHODS:Retrospective study of 35,902 hospital admissions. A single admissi...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1996-11-02 00:00:00
abstract::Nineteen patients with primary hypothyroidism were prospectively studied before starting replacement therapy with thyroid hormones. Most patients had mild to moderate muscle symptoms: generalized muscle weakness, myalgia and cramps, and increased serum levels of muscle enzymes. In two patients these features were the ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1990-06-23 00:00:00
abstract:BACKGROUND:Hip fractures are a major source of mortality and morbidity among the elderly. The aim of the present study is to try to identify predictors of death and of non-deambulation during the period of acute treatment. PATIENTS AND METHODS:Consecutive prospective study of 459 patients older than 65 years admitted ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1998-05-23 00:00:00
abstract:BACKGROUND:In 1993 a first study on the scientific production of Spain in 1986-1989 on Biomedicine and Health Sciences, through the Science Citation Index (SCI) was published. The analysis attained the level of centres, with special emphasis in those related to the Health Care System. This paper analyses the period 199...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1997-10-18 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Our goal was to analyze the epidemiological and clinical findings, as well as the diagnostic approach in a group of patients in whom uveitis was the first manifestation of sarcoidosis. PATIENTS AND METHOD:Retrospective study (between March 1998 and July 2002) including 31 patients diagnosed wi...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(04)74374-2
更新日期:2004-05-22 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Gaucher disease is an inherited disorder caused by deficit of acid β-glucocerebrosidase, responsible for the degradation of glucosylceramide to ceramide and glucose. Although the disorder is primarily hematologic, bone is the second most commonly affected structure. Cathepsin K (CATK) is an enz...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2014.11.018
更新日期:2015-10-05 00:00:00
abstract:BACKGROUND AND OBJECTIVE:A common Leu7Pro polymorphism in the signal peptide of neuropeptide Y has been associated with increased plasma cholesterol and accelerated atherosclerosis in the Finnish population. SUBJECTS AND METHOD:A cross-sectional design was carried out in 1,000 individuals from the Mediterranean Spanis...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(03)73695-1
更新日期:2003-03-15 00:00:00
abstract::Clinical journals often publish economic evaluation studies of health technologies and programs. To improve the peer review process and, hence, the quality and validity of published studies, the British Medical Journal (BMJ) established publication guidelines for the publication of economic evaluations aimed at author...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(05)72212-0
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:We have not found any study assessing the sensitivity of different frequencies of nosocomial infection surveillance (NIS). The objective of this study is to contribute to the ascertainment of the frequency of the NIS surveillance in surgical patients, where NIS has shown to be most efficient. METHODS:A pros...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1997-02-08 00:00:00
abstract:BACKGROUND:In recent years there has been a change in the opportunistic diseases incidence in HIV-infected patients. The change could be related to the use antiviral therapy and chemoprophylaxis strategies. The aim of the present study was to evaluate if medical intervention is able to modificate the clinical presentat...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1998-02-07 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To know the frequency of nosocomial infection (NI) in surgical hip fracture patients and to analyze the risk factors that favor the NI development, especially its relationship with allogeneic blood transfusion (ABT) and intravenous iron administration. PATIENTS AND METHOD:Unicenter prospective...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13128722
更新日期:2008-11-15 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The aims of the GEMM Family Study are to clarify the genetic determinants of cardiovascular disease (CVD) risk in individuals born and living in Mexico. The authors evaluate the heritabilities (h2) of CVD risk factors in Mexicans from a preliminary cohort already studied. Heritabilities for CVD...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13106675
更新日期:2007-06-02 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) are excellent predictive factors of tissue damage, inflammation and infection. However, there is not sufficient data about their usefulness in elderly patients with acute septic pathology. Our objective was to identify the cytokines related ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(03)73952-9
更新日期:2003-09-27 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Two different pathways for the development of tumor have been described in colorectal carcinoma: the chromosomic instability, raised by suppressor genes and proto-oncogene alterations, and the microsatellite instability (MSI), caused by alterations in DNA repairing genes. PATIENTS AND METHOD:T...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13071004
更新日期:2005-02-05 00:00:00
abstract::A 75 year-old male presented with hyperkalemia unexplained by a moderate renal insufficiency, low basal levels of aldosterone and renin with a subnormal response to walking and saline depletion, and normal glucocorticoid function. The hyperkalemia was corrected by fluorocortisone administration. The concept of hypoald...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1980-11-10 00:00:00
abstract::Pulmonary complications in HIV-infected patients are at present a first-rate problem. They are the main cause of hospital admission of these patients in our country. Most HIV-patients have a pulmonary complication during the evolution of the infection. The main etiologic diagnosis is bacterial pneumonia, especially pn...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1157/13080461
更新日期:2005-10-22 00:00:00
abstract:BACKGROUND:Bone mineral density (BMD) has been related with age, hormonal status, body mass index (BMI) and life style. We have evaluated the influence of these factors on BMD in healthy women, without risk factors for osteoporosis, using ultrasound measures. PATIENTS AND METHODS:We have selected 255 women (136 premen...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1999-09-18 00:00:00
abstract::The association of celiac disease, epilepsy and occipital calcifications with initial clinical manifestations of epilepsy during the first two decades of life with an often progressive and variable course and clinical expression of malabsorption has recently been described. Two cases of celiac disease with occipital c...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1995-12-08 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Direct oral anticoagulants (DOACs) require dose adjustment according to estimated clearance creatinine (eClCr) using the Cockcroft-Gault (CG) equation. There are discrepancies with the equations that estimate glomerular filtration rate (eGFR). We analyse how the use of the CKD-EPI and MDRD-4 ID...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2017.06.003
更新日期:2018-02-09 00:00:00
abstract::In this study, we review the efficacy and safety limitations of insulin-dependent oral antidiabetic agents. In terms of efficiency, the main drawback of metformin, sulfonylureas, gliptins and -to a lesser extent-glitazones is durability. No drug per se is able to maintain stable blood glucose control for years. Metfor...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/S0025-7753(13)70059-9
更新日期:2013-09-01 00:00:00
abstract::Podoconiosis, mossy foot or endemic non-filarial elephantiasis, is a geochemical disease that causes lower limb lymphedema; it is directly related to walking barefoot over soils of volcanic origin, in areas with a high pluviometric annual index. It has a specific geographical distribution, affecting around 5% populati...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2014.12.020
更新日期:2015-11-20 00:00:00
abstract::Amebian hepatic abscess (AHA) is the most frequent extraintestinal localization of infection by Entamoeba histolytica. Despite being a disease mainly of tropical zones, it is currently also observed with higher frequency in Spain. Thirteen cases of AHA diagnosed in the authors' hospital over the last 11 years were ret...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1995-10-28 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Multiple chemical sensitivity (MCS) is characterized by a loss of tolerance to various environmental chemicals. The objective of this study was to describe patients with MCS seen in our hospital. PATIENTS AND METHOD:Patients consecutively seen by the Toxicology and Chronic Fatigue Units who pr...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13107370
更新日期:2007-06-16 00:00:00