Implications of a two-stage clonal expansion model to indoor radon risk assessment.

Abstract:

:Spreadsheet macro programs for calculations of exact hazard and probability of having contracted cancer were used to study the implications of the lung cancer model of Moolgavkar et al. Excess lifetime risk ELR and loss of life expectancy LLE were calculated from the annual values of hazard and probability, using published life tables. The influence of various factors on ELR and LLE was studied, as well as the lifetime risk projection in epidemiological studies. At indoor concentrations, ELR and LLE are coarsely proportional to lifetime exposure. The main factors determining the proportionality coefficient are 1. Smoking status, 2. General life expectancy, 3. Exposure schedule, and 4. Sex. For constant domestic exposure, the sex is less important, because the longer life of women is compensated by the lower hazard. ELR and LLE for a population with 30% smokers and life expectancies of 72.1 y and 79.5 y for men and women, respectively, are 56 per million per WLM and 860 y per million per WLM, respectively. For an exposure schedule with one high radon period, the mean age during the period becomes important, and the age-specific values for men and women differ from each other. Furthermore, the model predicts that case-control epidemiological studies overestimate the lifetime risk by an amount which may arise to several tens of percent.

journal_name

Health Phys

journal_title

Health physics

authors

Castrén O

doi

10.1097/00004032-199904000-00007

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

393-7

issue

4

eissn

0017-9078

issn

1538-5159

journal_volume

76

pub_type

杂志文章
  • Use of CAP88 at Department of Energy sites.

    abstract::The U.S. Department of Energy is committed to protecting the public and environment against undue risk from radiation associated with radiological activities conducted under its control. Some U.S. Department of Energy Site activities result in emissions of radioactive materials to the air. CAP88 codes are used to mode...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182904d8f

    authors: Snyder S,Vázquez G,Hay T

    更新日期:2013-08-01 00:00:00

  • Monte Carlo based method for conversion of in-situ gamma ray spectra obtained with a portable Ge detector to an incident photon flux energy distribution.

    abstract::A Monte Carlo based method for the conversion of an in-situ gamma-ray spectrum obtained with a portable Ge detector to photon flux energy distribution is proposed. The spectrum is first stripped of the partial absorption and cosmic-ray events leaving only the events corresponding to the full absorption of a gamma ray....

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199802000-00007

    authors: Clouvas A,Xanthos S,Antonopoulos-Domis M,Silva J

    更新日期:1998-02-01 00:00:00

  • Reconstruction of long-lived radionuclide intakes for Techa riverside residents: strontium-90.

    abstract::Releases of radioactive materials from the Mayak Production Association in 1949-1956 resulted in contamination of the Techa River; a nuclide of major interest was 90Sr, which downstream residents consumed with water from the river and with milk contaminated by cows' consumption of river water and contaminated pasture....

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e318206d0ff

    authors: Tolstykh EI,Degteva MO,Peremyslova LM,Shagina NB,Shishkina EA,Krivoshchapov VA,Anspaugh LR,Napier BA

    更新日期:2011-07-01 00:00:00

  • Comparison of in situ and laboratory gamma spectroscopy of natural radionuclides in desert soil.

    abstract::In situ and laboratory gamma spectroscopy were used to characterize natural background levels of radiation in the soil at eight sites around the Yucca Mountain Range. The purpose of this practical field analysis was to determine if published empirical in situ calibration factors would yield accurate quantitative speci...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199708000-00007

    authors: Benke RR,Kearfott KJ

    更新日期:1997-08-01 00:00:00

  • Radioactivity: conception to birth. The Health Physics Society 1995 Radiology Centennial Hartman Oration.

    abstract::Röntgen's description of his discovery of x rays was convincing and comprehensive. The response of the scientific community and public was immediate and intense. In contrast, the discovery of radioactivity was a muddled affair that excited little interest. While it would prove far more revolutionary than that of x ray...

    journal_title:Health physics

    pub_type: 历史文章,杂志文章

    doi:10.1097/00004032-199605000-00001

    authors: Frame PW

    更新日期:1996-05-01 00:00:00

  • Radiation dose implications of airborne contaminant deposition to humans.

    abstract::In nuclear accident consequence assessment, dose contributions from radionuclide deposition on the human body have in the past generally been either ignored or estimated on the basis of rather simple models. Recent experimental work has improved the state of knowledge of relevant processes and parameter ranges. The re...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200202000-00007

    authors: Andersson KG,Fogh CL,Byrne MA,Roed J,Goddard AJ,Hotchkiss SA

    更新日期:2002-02-01 00:00:00

  • Estimation of individualized radiation risk from chronic occupational exposure in Russia.

    abstract::Internationally, the upper limit of acceptable individualized risk from occupational exposure for nuclear industry workers is determined by the death probability 10(-3) y(-1). The same risk value of 10(-3) y(-1) is established by the radiation safety standards currently in force in Russia. The United Nations Scientifi...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000346702.02932.7d

    authors: Ivanov VK,Tsyb AF,Panfilov AP,Agapov AM,Kaidalov OV,Korelo AM,Maksioutov A,Chekin SY,Kashcheyeva PV

    更新日期:2009-08-01 00:00:00

  • Use of radiopharmaceuticals in diagnostic nuclear medicine in the United States: 1960-2010.

    abstract::To reconstruct reliable nuclear medicine-related occupational radiation doses or doses received as patients from radiopharmaceuticals over the last five decades, the authors assessed which radiopharmaceuticals were used in different time periods, their relative frequency of use, and typical values of the administered ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000261

    authors: Drozdovitch V,Brill AB,Callahan RJ,Clanton JA,DePietro A,Goldsmith SJ,Greenspan BS,Gross MD,Hays MT,Moore SC,Ponto JA,Shreeve WW,Melo DR,Linet MS,Simon SL

    更新日期:2015-05-01 00:00:00

  • Thorium concentration in human tissues from two U.S. populations.

    abstract::The concentrations of natural alpha-emitting isotopes of thorium (228Th, 230Th and 232Th) have been determined in 22 sets of human tissue samples obtained at autopsy from Grand Junction, CO and in 10 sets from Washington, DC. Tissues included lung, pulmonary lymph nodes, liver, kidney, bone, a few gonads, spleen and t...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198306001-00018

    authors: Ibrahim SA,Wrenn ME,Singh NP,Cohen N,Saccomano G

    更新日期:1983-01-01 00:00:00

  • Delayed Effects of Acute Radiation Exposure in a Murine Model of the H-ARS: Multiple-Organ Injury Consequent to

    abstract::The threat of radiation exposure from warfare or radiation accidents raises the need for appropriate animal models to study the acute and chronic effects of high dose rate radiation exposure. The goal of this study was to assess the late development of fibrosis in multiple organs (kidney, heart, and lung) in survivors...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000357

    authors: Unthank JL,Miller SJ,Quickery AK,Ferguson EL,Wang M,Sampson CH,Chua HL,DiStasi MR,Feng H,Fisher A,Katz BP,Plett PA,Sandusky GE,Sellamuthu R,Vemula S,Cohen EP,MacVittie TJ,Orschell CM

    更新日期:2015-11-01 00:00:00

  • Radon awareness and mitigation in Vermont: a public health survey.

    abstract::Radon exposure is associated with an increased incidence of lung cancer, and elevated levels may be found in as many as 1 out of 15 homes. The U.S. EPA recommends testing homes for radon and mitigating over the advisory level of 4 picocuries per liter (4 pCi L(-1), or 148 Bq m(-3)). A sample population from a list of ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000254862.50407.4a

    authors: Riesenfeld EP,Marcy TW,Reinier K,Mongeon JA,Trumbo CW,Wemple BE,Kaminsky DA

    更新日期:2007-05-01 00:00:00

  • A multidetector alpha spectroscopy analysis system.

    abstract::This document describes the attributes of an alpha spectroscopy counting and analysis system called Low Level Pulse Height Analysis (LLPHA). It was developed for multi-sample alpha spectroscopy analysis. The LLPHA system is controlled by a MIK-11/2 microcomputer with 28K of memory and uses a double-density, dual flopp...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198403000-00014

    authors: Guilmette RA,Archibeque FA

    更新日期:1984-03-01 00:00:00

  • Cost-Benefit of Final Radiological Survey Versus Radioactive Waste Disposal.

    abstract::ABSTRACT A significant portion of the cost for D&D is related to low-level waste disposal, decontamination, and final radiological survey. For that reason, a careful cost-benefit analysis must be performed weighing the cost of decontaminating and radiologically surveying the building media for release against the cost...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:

    authors: Barroso J,Roberts S

    更新日期:2003-02-01 00:00:00

  • Optimization of radiation doses received by personnel in PET uptake rooms.

    abstract::Reduction of dose to exposed personnel during positron emission tomography (PET) installation usually relies on physical shielding. While the major contribution of shielding is unquestioned, it is usually the only method applied. Other methods of reduction, such as working procedure optimization, the position of the f...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000178

    authors: Perez ME,Verde JM,Montes C,Ramos JA,García S,Hernandez J

    更新日期:2014-11-01 00:00:00

  • Radiation dose to the population of Slovak Republic from diagnostic nuclear medicine.

    abstract::This study estimated the radiation exposure attributed to nuclear medicine examinations during the period of 1985 through 1992 in Slovak Republic. It was accomplished by survey of nuclear medicine facilities from 1987 to 1992. In addition, a detailed analysis of nuclear medicine practice was obtained for 1992. The mea...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199507000-00003

    authors: Ftácniková S,Ragan P

    更新日期:1995-07-01 00:00:00

  • Root absorption of 222Rn and its transfer into above-ground plant organs.

    abstract::Experimental data are given on the content of genetically related pairs of radionuclides (226Ra and 222Rn; 224Ra and 220Rn) in soils and the above-ground phytomass of plants growing on plots with differing genesis of the higher concentrations of natural radionuclides in soils. Methods for determining gaseous radionucl...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198605000-00002

    authors: Taskayev AI,Popova ON,Alexakhin RM,Testov BV

    更新日期:1986-05-01 00:00:00

  • Environmental distribution and behavior of 3H and 14C around Wolsong Nuclear Power Plants.

    abstract::To estimate of the dispersion trend of 3H and 14C discharged from the Wolsung Nuclear Power Plants, the present level of 3H and 14C in environmental samples in the vicinity of the Wolsong site was studied. Tree-ring cellulose analyses were carried out for retrospective evaluation of 3H and 14C in the environment aroun...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200006000-00013

    authors: Kim CK,Lee SK,Rho BH,Lee YG

    更新日期:2000-06-01 00:00:00

  • Physical presence during gamma stereotactic radiosurgery.

    abstract::During an invited visit to the University of Pittsburgh Medical Center (UPMC) gamma knife facility, officials from the Nuclear Regulatory Commission (NRC) observed what they considered as an apparent violation of the physical presence requirements specified in 10 CFR 35.615(f)(3). This event initiated an inspection an...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000334061.89160.7f

    authors: Sheetz M,Swanson D,Yates B

    更新日期:2009-02-01 00:00:00

  • 137Cs exposure in the Marshallese populations: an assessment based on whole-body counting measurements (1989-1994).

    abstract::The Marshall Islands were the site of numerous tests of nuclear weapons by the United States. From 1946 to 1958, nuclear devices were detonated at Enewetak and Bikini Atolls. Following the inadvertent contamination of the northern islands downwind of the 1954 Bravo Test, Brookhaven National Laboratory became involved ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199707000-00007

    authors: Sun LC,Clinton JH,Kaplan E,Meinhold CB

    更新日期:1997-07-01 00:00:00

  • The U.S. government's medical countermeasure portfolio management for nuclear and radiological emergencies: synergy from interagency cooperation.

    abstract::Following the attacks of 11 September 2001, emergency preparedness within the U.S. Department of Health and Human Services, as well as at the Department of Defense and other federal agencies, received higher visibility, new mandates and increased funding. Emergency deployment teams increased the frequency of drills to...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182135fba

    authors: Grace MB,Cliffer KD,Moyer BR,Coleman CN,Prasher JM,Hatchett R,Mercier J,Manning RG,Bader JL,Disbrow GL,Kovacs GR

    更新日期:2011-09-01 00:00:00

  • Weak electric field interactions in the central nervous system.

    abstract::Exposure to extremely low frequency electric and magnetic fields will induce electric fields and currents within the body, but these are almost always much lower than those that can stimulate peripheral nerve tissue. Guidance on exposure to such fields has been published by NRPB and ICNIRP, which is based on the avoid...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200209000-00006

    authors: Saunders RD,Jefferys JG

    更新日期:2002-09-01 00:00:00

  • The H-ARS Dose Response Relationship (DRR): Validation and Variables.

    abstract::Manipulations of lethally-irradiated animals, such as for administration of pharmaceuticals, blood sampling, or other laboratory procedures, have the potential to induce stress effects that may negatively affect morbidity and mortality. To investigate this in a murine model of the hematopoietic acute radiation syndrom...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000354

    authors: Plett PA,Sampson CH,Chua HL,Jackson W,Vemula S,Sellamuthu R,Fisher A,Feng H,Wu T,MacVittie TJ,Orschell CM

    更新日期:2015-11-01 00:00:00

  • Analysis of exposure to electromagnetic fields in a healthcare environment: simulation and experimental study.

    abstract::Recent advances in wireless technologies have lead to an increase in wireless instrumentation present in healthcare centers. This paper presents an analytical method for characterizing electric field (E-field) exposure within these environments. The E-field levels of the different wireless communications systems have ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31828e5c15

    authors: de Miguel-Bilbao S,Martín MA,Del Pozo A,Febles V,Hernández JA,de Aldecoa JC,Ramos V

    更新日期:2013-11-01 00:00:00

  • Assessment of the natural radioactivity in the Brazilian state of Rio Grande do Norte.

    abstract::Fifty-one soil samples were collected to a depth of 30 cm in the central and eastern region of the Brazilian state of Rio Grande do Norte. Concentrations of background radionuclides in soil samples were determined by gamma ray spectrometry with an HPGe detector. The average concentrations of 226Ra, 232Th, and 40K in t...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199309000-00008

    authors: Malanca A,Pessina V,Dallara G

    更新日期:1993-09-01 00:00:00

  • Correlations between DNA polymorphism and frequencies of gamma-radiation induced and spontaneous cytogenetic damage.

    abstract::With the aim of developing genetic tests for elevated and reduced radiation sensitivity, the authors studied the correlations between various genotypes and frequencies of spontaneous and radiation-induced chromosome aberrations in human lymphocytes. Cytogenetic analysis and genotyping (19 sites of detoxification and D...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182231a9d

    authors: Salnikova L,Chumachenko A,Belopolskaya O,Rubanovich A

    更新日期:2012-07-01 00:00:00

  • Estimation of human gonadal Pu and Ce concentrations from animal data.

    abstract::Data were obtained from the literature for gonad and body weights and for the Pu or Ce content of the gonads and body at death for several laboratory animal species, five human Pu injection cases, and 731 human adults exposed environmentally to Pu in fallout. Data for Pu concentration in gonads, liver, and bone sample...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198907001-00012

    authors: Thomas RG,Durbin PW,McInroy JF,Healy JW

    更新日期:1989-01-01 00:00:00

  • Personal and home 222Rn and gamma-ray exposure measured in 52 dwellings.

    abstract::A personal 222Rn and gamma-ray detector has been developed. The detector precision is limited only by the Poisson counting error and has a lower limit of detection in this study of 4.5 kBq m-3 h (4 pCi L-1 day). The detector was used in a study of 52 homes in Illinois to measure the personal exposure vs. the simultane...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199112000-00004

    authors: Harley NH,Chittaporn P,Roman MH,Sylvester J

    更新日期:1991-12-01 00:00:00

  • Deterministic Effects to the Lens of the Eye Following Ionizing Radiation Exposure: is There Evidence to Support a Reduction in Threshold Dose?

    abstract::Ionizing radiation exposure to the lens of the eye is a known cause of cataractogenesis. Historically, it was believed that the acute threshold dose for cataract formation was 5 Sv, and annual dose limits to the lens were set at 150 mSv. Recently, however, the International Commission on Radiological Protection has re...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000810

    authors: Thome C,Chambers DB,Hooker AM,Thompson JW,Boreham DR

    更新日期:2018-03-01 00:00:00

  • Tumors and other diseases following childhood x-ray treatment for ringworm of the scalp (Tinea capitis).

    abstract::The objective of the study is to characterize the risk of tumors from radiation exposure to the head and neck. A cohort of 2,224 children given x-ray treatment and 1,380 given only topical medications for ringworm of the scalp (tinea capitis) during 1940-1959 have been followed up for a median of 39 y to determine tum...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200310000-00003

    authors: Shore RE,Moseson M,Harley N,Pasternack BS

    更新日期:2003-10-01 00:00:00

  • Spatial variation of residential radon concentrations: the Iowa Radon Lung Cancer Study.

    abstract::Homeowners and researchers frequently estimate the radon concentrations in various areas of the home from a single radon measurement often performed in the home's basement. This study describes the spatial variation of radon concentrations both between floors and between rooms on the same floor. The geometric mean bas...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199811000-00007

    authors: Fisher EL,Field RW,Smith BJ,Lynch CF,Steck DJ,Neuberger JS

    更新日期:1998-11-01 00:00:00