Deterministic Effects to the Lens of the Eye Following Ionizing Radiation Exposure: is There Evidence to Support a Reduction in Threshold Dose?

Abstract:

:Ionizing radiation exposure to the lens of the eye is a known cause of cataractogenesis. Historically, it was believed that the acute threshold dose for cataract formation was 5 Sv, and annual dose limits to the lens were set at 150 mSv. Recently, however, the International Commission on Radiological Protection has reduced their threshold dose estimate for deterministic effects to 0.5 Gy and is now recommending an occupational limit of 20 mSv per year on average. A number of organizations have questioned whether this new threshold and dose limit are justified based on the limited reliable data concerning radiation-induced cataracts. This review summarizes all of the published human epidemiological data on ionizing radiation exposure to the lens of the eye in order to evaluate the proposed threshold. Data from a variety of exposure cohorts are reviewed, including atomic bomb survivors, Chernobyl liquidators, medical workers, and radiotherapy patients. Overall, there is not conclusive evidence that the threshold dose for cataract formation should be reduced to 0.5 Gy. Many of the studies reviewed here are challenging to incorporate into an overall risk model due to inconsistencies with dosimetry, sample size, and scoring metrics. Additionally, risk levels in the studied cohorts may not relate to occupational scenarios due to differences in dose rate, radiation quality, age at exposure and latency period. New studies should be designed specifically focused on occupational exposures, with reliable dosimetry and grading methods for lens opacities, to determine an appropriate level for dose threshold and exposure limit.

journal_name

Health Phys

journal_title

Health physics

authors

Thome C,Chambers DB,Hooker AM,Thompson JW,Boreham DR

doi

10.1097/HP.0000000000000810

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

328-343

issue

3

eissn

0017-9078

issn

1538-5159

pii

00004032-201803000-00007

journal_volume

114

pub_type

杂志文章
  • A multi-functional electronic program for the management of radioisotopes.

    abstract::Everyone will agree that specialized computer programs have done away with the many tedious tasks associated with manually keeping track of radioisotopes. Enhanced electronic programs have virtually cut the time of managing radioisotopes. Agriculture and Agri-Food, Canada's (AAFC) program for the management of radiois...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000308501.32700.f1

    authors: Ritchot N,Santary W

    更新日期:2008-05-01 00:00:00

  • An experimental and mathematical analysis of lymphopoiesis dynamics under continuous irradiation.

    abstract::A mathematical model describing the dynamics of lymphopoiesis in mammals continuously exposed to ionizing radiation has been developed. It is based on the theory of chalone regulation of hematopoiesis. The model comprises a system of nine differential equations. Results from the model were compared with our experiment...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199107000-00009

    authors: Zukhbaya TM,Smirnova OA

    更新日期:1991-07-01 00:00:00

  • Modeling the Optimum Prussian Blue Treatment for Acute Radiation Syndrome Following 137Cs Ingestion.

    abstract::Accidents or radiological attacks may lead to ingestion of Cs by large numbers of the public. This work models the efficacy of Prussian blue, the medical countermeasure for internal contamination with Cs, to prevent acute radiation syndrome as a function of the duration of treatment and the time that treatment starts ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000966

    authors: Adams TG,Casagrande R

    更新日期:2019-01-01 00:00:00

  • Effects of Medical Diagnostic Low-dose X Rays on Human Lymphocytes: Mitochondrial Membrane Potential, Apoptosis and Cell Cycle.

    abstract::Low-dose radiation is widely used across the world for the diagnosis of many diseases by means of a variety of imaging technologies. However, the harmful effects of exposure to low-dose radiation during medical examination remain controversial. The authors studied the effects of medical diagnostic low-dose x rays (i.e...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000647

    authors: Tungjai M,Phathakanon N,Rithidech KN

    更新日期:2017-05-01 00:00:00

  • Comparison of sliced and whole lung sets for the LLNL and JAERI torso phantoms using GE detectors.

    abstract::The performance characteristics of sliced lung sets were compared to lung sets with activity homogeneously distributed throughout the lung tissue substitute material. The activity estimate from planar sources differs from the estimate from homogeneous sources by a factor of 0.88 to 1.09 depending on the photon energy....

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199905000-00013

    authors: Kramer GH,Hauck BM,Lee TY,Chang SY

    更新日期:1999-05-01 00:00:00

  • The probability that a specific cancer and a specified radiation exposure are causally related.

    abstract::It is fundamental that a given cancer case cannot be attributed with absolute certainty to a prior ionizing radiation exposure, whatever the level of exposure. It is possible to estimate the probability of a causal relationship based on data and models that have been inferred from group statistics. Two types of inform...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198808000-00038

    authors: Breitenstein BD

    更新日期:1988-08-01 00:00:00

  • Radiation hormesis: challenging LNT theory via ecological and evolutionary considerations.

    abstract::Ecological and evolutionary considerations suggest that radiation hormesis is made up of two underlying components. The first (a) is background radiation hormesis based upon the background exposure to which all organisms are subjected throughout evolutionary time. The second and much larger component (b) is stress-der...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200204000-00011

    authors: Parsons PA

    更新日期:2002-04-01 00:00:00

  • New technologies in radiation therapy: ensuring patient safety, radiation safety and regulatory issues in radiation oncology.

    abstract::New technologies such as intensity modulated and image guided radiation therapy, computer controlled linear accelerators, record and verify systems, electronic charts, and digital imaging have revolutionized radiation therapy over the past 10-15 y. Quality assurance (QA) as historically practiced and as recommended in...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000326334.64242.46

    authors: Amols HI

    更新日期:2008-11-01 00:00:00

  • Inhalation reference dose (RfDi): an application of interspecies dosimetry modeling for risk assessment of insoluble particles.

    abstract::Accurate extrapolation of animal toxicity data for human health risk assessment requires determination of the effective dose to the target tissue and the sensitivity of the target tissue to that dose. The methodology for deriving reference doses [the U.S. Environmental Protection Agency's (EPA) benchmark values for ga...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198907001-00022

    authors: Jarabek AM,Menache MG,Overton JH Jr,Dourson ML,Miller FJ

    更新日期:1989-01-01 00:00:00

  • Further studies of plutonium and americium at Thule, Greenland.

    abstract::Eleven years after the accidental loss of nuclear weapons in 1968, the fourth scientific expedition to Thule occurred. The estimated inventory of 1 TBq 239,240Pu in the marine sediments was unchanged when compared with the estimate based on the 1974 data. Plutonium from the accident had moved further away from the imp...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198401000-00001

    authors: Aarkrog A,Dahlgaard H,Nilsson K,Holm E

    更新日期:1984-01-01 00:00:00

  • Lauriston S. Taylor lecture: Radiation Protection and Public Policy in an Uncertain World.

    abstract::Ionizing radiation is a known, well-documented, and reasonably well-quantified human cancer risk factor based on a remarkably consistent body of dose-response information from epidemiological studies of exposed populations supported by experimental studies using animal and cellular models. This fact is largely ascriba...

    journal_title:Health physics

    pub_type:

    doi:10.1097/HP.0b013e318227e822

    authors: Land CE

    更新日期:2011-11-01 00:00:00

  • Photon-Fluence-Weighted let for Radiation Fields Subjected to Epidemiological Studies.

    abstract::In order to estimate the uncertainty of the radiation risk associated with the photon energy in epidemiological studies, photon-fluence-weighted LET values were quantified for photon radiation fields with the target organs and irradiation conditions taken into consideration. The photon fluences giving a unit absorbed ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000683

    authors: Sasaki M

    更新日期:2017-08-01 00:00:00

  • A consistent radionuclide vector after the Chernobyl accident.

    abstract::The radionuclide vector in the release plume from the destroyed unit 4 of the Chernobyl Nuclear Power Plant was assessed. Emphasis was laid on radionuclides relevant for the internal dose, including those with short half-lives, and on the radionuclide vector in the 30-km zone where practically no data in air or foodst...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200202000-00002

    authors: Mück K,Pröhl G,Likhtarev I,Kovgan L,Meckbach R,Golikov V

    更新日期:2002-02-01 00:00:00

  • Organ Doses From Diagnostic Medical Radiography-Trends Over Eight Decades (1930 to 2010).

    abstract::This study provides a retrospective assessment of doses to 13 organs for the most common radiographic examinations conducted between the 1930s and 2010, taking into account typical technical parameters used for radiography during those years. This study is intended to be a resource on changes in medical diagnostic rad...

    journal_title:Health physics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/HP.0000000000000524

    authors: Melo DR,Miller DL,Chang L,Moroz B,Linet MS,Simon SL

    更新日期:2016-09-01 00:00:00

  • Perception of ELF electromagnetic fields: excitation thresholds and inter-individual variability.

    abstract::So far, in guidelines limiting exposure to electromagnetic fields, basic limits of intracorporal electric current densities have been recommended to prevent from nerve cell stimulation. They were based on experimental data and extrapolated to the general population with limited knowledge on the inter-individual variab...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/01.HP.0000243128.29337.aa

    authors: Leitgeb N,Schröttner J,Cech R

    更新日期:2007-06-01 00:00:00

  • Somatic-cell mutations as a possible predictor of cancer risk.

    abstract::The somatic-mutation theory of carcinogenesis has received strong scientific support from results of recent studies on tumor-suppressor genes. We anticipated that people among the high risk for cancer group, either through exposure to various ionizing radiations or by virtue of unique genotypes, would also manifest in...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199505000-00003

    authors: Akiyama M,Umeki S,Kusunoki Y,Kyoizumi S,Nakamura N,Mori T,Ishikawa Y,Yamakido M,Ohama K,Kodama T

    更新日期:1995-05-01 00:00:00

  • Systematic indoor radon and gamma-ray measurements in Slovenian schools.

    abstract::During the winter months of 1992/93 and 1993/94, instantaneous indoor radon concentrations and gamma dose rates were measured in 890 schools in Slovenia attended in total by about 280,000 pupils. Under "closed conditions," the room to be surveyed was closed for more than 12 h prior to sampling, the air was sampled int...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200005000-00014

    authors: Vaupotic J,Sikovec M,Kobal I

    更新日期:2000-05-01 00:00:00

  • Proposed revision of the ICRP model for inhaled mercury vapor.

    abstract::A critical review of the literature on the biokinetics of inhaled mercury vapor was performed as part of an accident analysis for the Spallation Neutron Source to be built at Oak Ridge National Laboratory. It was concluded that current models for inhaled mercury vapor do not accurately describe the distribution or res...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200110000-00010

    authors: Leggett RW,Munro NB,Eckerman KF

    更新日期:2001-10-01 00:00:00

  • The distribution of Thorotrast in human bone marrow: a case report.

    abstract::Samples of bone containing cellular and fatty bone marrow were removed at autopsy from the body of a woman who, following an automobile accident, had been injected with approximately 25 mL of the radiographic contrast medium Thorotrast. The woman survived for 36 y after the accident and died at age 72 y following bone...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199207000-00007

    authors: Priest ND,Humphreys JA,Kathren RL,Mays CW

    更新日期:1992-07-01 00:00:00

  • Reconstruction of long-lived radionuclide intakes for Techa riverside residents: strontium-90.

    abstract::Releases of radioactive materials from the Mayak Production Association in 1949-1956 resulted in contamination of the Techa River; a nuclide of major interest was 90Sr, which downstream residents consumed with water from the river and with milk contaminated by cows' consumption of river water and contaminated pasture....

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e318206d0ff

    authors: Tolstykh EI,Degteva MO,Peremyslova LM,Shagina NB,Shishkina EA,Krivoshchapov VA,Anspaugh LR,Napier BA

    更新日期:2011-07-01 00:00:00

  • Reconstruction of Enriched Uranium Released to Air from the Former Apollo Facility, Apollo, Pennsylvania.

    abstract::The former Apollo facility converted enriched uranium hexafluoride into uranium oxide for shipment to nuclear fuel fabrication plants from 1957 to 1983. This paper describes quantification of the source term from the Apollo facility in terms of quantities of uranium released, particle size, and solubility characterist...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001343

    authors: Caffrey EA,Voillequé PG,Rood AS,Grogan HA,Mohler HJ,Meyer KR,Till JE

    更新日期:2020-12-11 00:00:00

  • Occupational Radiation Protection Aspects of Alkaline Leach Uranium in Situ Recovery (ISR) Facilities in the United States.

    abstract::In situ recovery or in situ leach (ISR/ISL) uranium facilities, also referred to in the past as "uranium solution mining" have operated since the late 1960s in the US and in recent years have accounted for over 70% of US production and, internationally, approximately half of worldwide uranium supplies. Note that throu...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001062

    authors: Brown SH

    更新日期:2019-07-01 00:00:00

  • Occupational exposure to dial painters and assemblers of radioluminous timepieces.

    abstract::An evaluation of available personnel monitoring data and radium body burden records of dial painters handling an annual average of 1.5 Ci of radium indicates that they received an average of about 2 rem/person whole body exposure, 3 rem to the lungs from radon inhalation and 0.2 rad to the bone from radium body burden...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198305000-00004

    authors: Simpson RE,Shuman FG,Moghissi AA,Blackburn JA,Bailey ED

    更新日期:1983-05-01 00:00:00

  • Reconstruction of two victims' posturing based on the induced radioactivities in their bones in the criticality accident in Tokai-Mura, Japan.

    abstract::On 30 September 1999, three workers were severely exposed to neutrons and gamma rays in a criticality accident that occurred at a uranium conversion facility in Tokai-mura, Ibaraki Prefecture, Japan. Radiochemical analyses of 32P and 45Ca induced by neutrons in bone matrix were carried out after the deaths of two of t...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200207000-00002

    authors: Miyamoto K,Watanabe Y,Yukawa M,Takeda H,Nishimura Y,Ishigure N,Hirama T,Akashi M

    更新日期:2002-07-01 00:00:00

  • A comparison between gross and net count methods when searching for orphan radioactive sources.

    abstract::Different numerical strategies in searching for orphan radioactive sources in the environment by means of a mobile detector system have been evaluated. A carborne 3- by 3-inch NaI(Tl) spectrometric system was used with an unshielded 2 GBq 137Cs source as a test source. In this paper, a previous method (MB method), bas...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200302000-00008

    authors: Hjerpe T,Samuelsson C

    更新日期:2003-02-01 00:00:00

  • The beagle: an appropriate experimental animal for extrapolating the organ distribution pattern of Th in humans.

    abstract::The concentrations and the organ distribution patterns of 228Th, 230Th and 232Th in two 9-y-old dogs of our beagle colony were determined. The dogs were exposed only to background environmental levels of Th isotopes through ingestion (food and water) and inhalation as are humans. The organ distribution patterns of the...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198803000-00006

    authors: Singh NP,Zimmerman CJ,Taylor GN,Wrenn ME

    更新日期:1988-03-01 00:00:00

  • Sample bottle design improvements for radon emanation analysis of natural waters.

    abstract::The "radon emanation" method of analysis for Rn and Ra in natural waters has been used by scientists for more than 30 years. We have examined the use of a new plastic bottle design as a viable option and improvement to traditional glass designs. The advantages of the new design over that used previously in our laborat...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:

    authors: Stringer CE,Burnett WC

    更新日期:2004-12-01 00:00:00

  • Do the risks justify action?

    abstract::The key issues that have been raised at the meeting on Cosmic Radiation Doses to Air Crew and Astronauts are identified. The paper summarizes the radiation environment and radiation risks associated with exposures to both groups. Finally, the summary concludes that the risks do justify action. ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200011000-00023

    authors: Clarke RH

    更新日期:2000-11-01 00:00:00

  • Body K and 40K in Chinese subjects measured with a whole-body counter.

    abstract::More than 380 Chinese adults of both sexes were studied for their total body K and 40K using the National Tsing Hua University whole-body counter. The K values were found to have an average of 1.75 +/- 0.4 g K kg-1 body weight for males and 1.41 +/- 0.1 g K kg-1 body weight for females. The average K value for both se...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198911000-00006

    authors: Lan CY,Weng PS

    更新日期:1989-11-01 00:00:00

  • Uptake of 244Cm, 238Pu and other radionuclides by trees inhabiting a contaminated flood plain.

    abstract::The plant uptake of 244Cm, 137Cs, 238Pu and 90Sr was measured for trees in a flood plain forest whose soils were contaminated by aqueous discharges from a nuclear-fuel chemical separations facility. Uptake of the naturally occurring radionuclide 226Ra was also measured. The relative availability of the nuclides was 23...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198409000-00003

    authors: Pinder JE 3rd,McLeod KW,Alberts JJ,Adriano DC,Corey JC

    更新日期:1984-09-01 00:00:00