Correlations between DNA polymorphism and frequencies of gamma-radiation induced and spontaneous cytogenetic damage.

Abstract:

:With the aim of developing genetic tests for elevated and reduced radiation sensitivity, the authors studied the correlations between various genotypes and frequencies of spontaneous and radiation-induced chromosome aberrations in human lymphocytes. Cytogenetic analysis and genotyping (19 sites of detoxification and DNA repair genes) were carried out for a group of cleanup workers of the Chernobyl nuclear power plant accident (83 people) and for a uniform control group of volunteers (97 people). In both cases, the frequencies of chromosome type aberrations were higher in carriers of minor alleles of gene XPD [sites T2251G (Lys751Gln) and G862A (Asp312Asn)] and the "positive" genotypes GSTM1/GSTT1. The polymorphism of these genes did not affect the frequency of aberrations induced by gamma radiation in the control group (1 Gy in vitro), which was associated with genotypes by loci OGG1, XRCC1, and CYP1A1. Thus, in the control group, spontaneous and in vitro induced cytogenetic effects are associated with different groups of polymorphic genes. In the cleanup workers group (irradiated in vivo), the elevated frequency of aberrations was observed in the carriers of those genotypes that typically have a higher level of spontaneous (but not in vitro induced) cytogenetic damage in the control. The genotype "minor XPD + insertion GST," having an estimated incidence of 64% in central Russia, was characterized and found to be strongly associated with an elevated frequency of chromosome type aberrations following irradiation in vivo (OR = 6.9; p = 0.008).

journal_name

Health Phys

journal_title

Health physics

authors

Salnikova L,Chumachenko A,Belopolskaya O,Rubanovich A

doi

10.1097/HP.0b013e3182231a9d

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

37-41

issue

1

eissn

0017-9078

issn

1538-5159

pii

00004032-201207000-00006

journal_volume

103

pub_type

杂志文章
  • Do the risks justify action?

    abstract::The key issues that have been raised at the meeting on Cosmic Radiation Doses to Air Crew and Astronauts are identified. The paper summarizes the radiation environment and radiation risks associated with exposures to both groups. Finally, the summary concludes that the risks do justify action. ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200011000-00023

    authors: Clarke RH

    更新日期:2000-11-01 00:00:00

  • Risk communication considerations to facilitate the screening of mass populations for potential contamination with radioactive material.

    abstract::Experience gained during a field training exercise with a Medical Reserve Corps unit on the screening of large groups of individuals for possible contamination with radioactive material revealed that while exercise participants were generally attentive to the proper use of protective equipment and detectors, they tend...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000324204.28443.ae

    authors: Emery RJ,Sprau DD,Morecook RC

    更新日期:2008-11-01 00:00:00

  • The U.S. government's medical countermeasure portfolio management for nuclear and radiological emergencies: synergy from interagency cooperation.

    abstract::Following the attacks of 11 September 2001, emergency preparedness within the U.S. Department of Health and Human Services, as well as at the Department of Defense and other federal agencies, received higher visibility, new mandates and increased funding. Emergency deployment teams increased the frequency of drills to...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182135fba

    authors: Grace MB,Cliffer KD,Moyer BR,Coleman CN,Prasher JM,Hatchett R,Mercier J,Manning RG,Bader JL,Disbrow GL,Kovacs GR

    更新日期:2011-09-01 00:00:00

  • The health physics society: a 50-year chronology.

    abstract::In 2005, the Health Physics Society celebrates its 50th anniversary. During its half century of existence, the Society has evolved from a small group of operationally oriented radiation protection scientists into an organization of several thousand with a recognized and respected peer reviewed journal. The bold decisi...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:

    authors: Boerner AJ,Kathren RL

    更新日期:2005-03-01 00:00:00

  • An investigation into the prevalence of thyroid disease on Kwajalein Atoll, Marshall Islands.

    abstract::The prevalence of thyroid nodules and thyroid cancer was studied in the indigenous population residing on Ebeye Island, Kwajalein Atoll, in the Republic of the Marshall Islands. This island, centrally located in the nation, is home to about 25% of the nation's population, many who have migrated there from other atolls...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199707000-00017

    authors: Takahashi T,Trott KR,Fujimori K,Simon SL,Ohtomo H,Nakashima N,Takaya K,Kimura N,Satomi S,Schoemaker MJ

    更新日期:1997-07-01 00:00:00

  • Fallout 3H in human tissue at Akita, Japan.

    abstract::The 3H concentration in Japanese human tissue samples is reported in this paper. Four brain, 10 liver, and nine lung samples from 11 cases were collected from Akita Prefecture in northern Japan from January to July 1986. The median of free-water 3H concentration was similar in these tissues and agreed well with the co...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198910000-00006

    authors: Hisamatsu S,Takizawa Y,Itoh M,Ueno K,Katsumata T,Sakanoue M

    更新日期:1989-10-01 00:00:00

  • The acute gastrointestinal subsyndrome of the acute radiation syndrome: a rhesus macaque model.

    abstract::The development of medical countermeasures against the acute gastrointestinal subsyndrome of the acute radiation syndrome in humans requires well characterized and validated animal models. These models must adhere to the criteria of the U.S. Food and Drug Administration's Animal Rule and consider the natural history a...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31826525f0

    authors: MacVittie TJ,Farese AM,Bennett A,Gelfond D,Shea-Donohue T,Tudor G,Booth C,McFarland E,Jackson W 3rd

    更新日期:2012-10-01 00:00:00

  • Root absorption of 222Rn and its transfer into above-ground plant organs.

    abstract::Experimental data are given on the content of genetically related pairs of radionuclides (226Ra and 222Rn; 224Ra and 220Rn) in soils and the above-ground phytomass of plants growing on plots with differing genesis of the higher concentrations of natural radionuclides in soils. Methods for determining gaseous radionucl...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198605000-00002

    authors: Taskayev AI,Popova ON,Alexakhin RM,Testov BV

    更新日期:1986-05-01 00:00:00

  • Historical estimates of external gamma exposure and collective external gamma exposure from testing at the Nevada Test Site. I. Test series through HARDTACK II, 1958.

    abstract::In 1959, the Test Manager's Committee to Establish Fallout Doses calculated estimated external gamma exposure at populated locations based upon measurements of external gamma-exposure rate. Using these calculations and estimates of population, we have tabulated the collective estimated external gamma exposures for com...

    journal_title:Health physics

    pub_type: 历史文章,杂志文章

    doi:10.1097/00004032-198607000-00003

    authors: Anspaugh LR,Church BW

    更新日期:1986-07-01 00:00:00

  • Intercomparison of Commercially Available Active Radon Measurement Devices in a Discovered Radon Chamber.

    abstract::An unventilated 70 m underground space, with 2.1 m high ceilings and an inner set of concrete walls to damp vibrations, was discovered to have relatively stable radon levels of ~1,080 Bq m over a 1-y period. The addition of radium sources was not required to achieve high and somewhat variable radon levels, as these ar...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001047

    authors: Carmona MA,Kearfott KJ

    更新日期:2019-06-01 00:00:00

  • Neutron response of a polyethylene-moderated superheated drop detector.

    abstract::Monte Carlo neutron transport calculations were performed to obtain the neutron response functions of a superheated drop detector (SDD-100) that is surrounded by polyethylene of various thicknesses. The calculational results suggest that a SDD-100 surrounded by 2.54 cm of polyethylene gives the best dose-equivalent re...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199203000-00001

    authors: Wang CK

    更新日期:1992-03-01 00:00:00

  • External doses to humans from 137Cs in soil.

    abstract::Calculations of absorbed doses in organs of the human body and the total effective dose due to Cs in soil as a source of external exposure are presented in this work. Calculations were done using the MCNP-4B software package. The assumption was made that photons with an energy of 662 keV are emitted in a cylindrical v...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000214136.56619.2d

    authors: Krstić D,Nikezić D

    更新日期:2006-09-01 00:00:00

  • Dose-dependent analysis of acute medical effects of mixed neutron-gamma radiation from selected severe 235U or 239Pu criticality accidents in USSR, United States, and Argentina.

    abstract::Eight of the most severe cases of acute radiation disease (ARS) known to have occurred in humans (as the result of criticality accidents) had survival times less than 120 h (herein defined as "early death"). These accidents were analyzed and are discussed with respect to the specific accident scenarios and the resulti...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e31823b4b78

    authors: Barabanova T,Wiley AL,Bushmanov A

    更新日期:2012-04-01 00:00:00

  • Basis for the ICRP's age-specific biokinetic model for uranium.

    abstract::In an effort motivated largely by the Chernobyl nuclear accident, the International Commission on Radiological Protection (ICRP) is developing age-specific biokinetic models and dose coefficients for environmentally important radionuclides. This paper describes the ICRP's age-specific biokinetic model for uranium. The...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/00004032-199412000-00002

    authors: Leggett RW

    更新日期:1994-12-01 00:00:00

  • Electromagnetic interference with infusion pumps from GSM mobile phones.

    abstract::Electromagnetic interference with critical medical care devices has been reported by various groups. Previous studies have demonstrated that volumetric and syringe pumps are susceptible to false alarm buzzing and blocking when exposed to various electromagnetic sources. The risk of electromagnetic interference depends...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000183559.25124.5d

    authors: Calcagnini G,Floris M,Censi F,Cianfanelli P,Scavino G,Bartolini P

    更新日期:2006-04-01 00:00:00

  • Sensitivity of portable personnel portal monitors: potential problems when dealing with contaminated persons.

    abstract::Health physicists are usually concerned with small amounts of radioactivity and strive to develop techniques to measure them; however, following a terrorist attack involving radioactive materials the converse might be the case, and exposed persons may be heavily contaminated. The Human Monitoring Laboratory (HML) has ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000218425.48988.f3

    authors: Kramer GH,Capello K,Hauck BM,Brown JT

    更新日期:2006-10-01 00:00:00

  • Metabolism and dosimetry of tritium.

    abstract::This document was prepared as a review of the current knowledge of tritium metabolism and dosimetry. The physical, chemical, and metabolic characteristics of various forms of tritium are presented as they pertain to performing dose assessments for occupational workers and for the general public. For occupational worke...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/00004032-199312000-00003

    authors: Hill RL,Johnson JR

    更新日期:1993-12-01 00:00:00

  • Test of the linear-no threshold theory of radiation carcinogenesis for inhaled radon decay products.

    abstract::Data on lung cancer mortality rates vs. average radon concentration in homes for 1,601 U.S. counties are used to test the linear-no threshold theory. The widely recognized problems with ecological studies, as applied to this work, are addressed extensively. With or without corrections for variations in smoking prevale...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199502000-00002

    authors: Cohen BL

    更新日期:1995-02-01 00:00:00

  • An evaluation of the Kearny Fallout Meter (KFM), a radiation detector constructed from commonly available household materials.

    abstract::A radiation detector constructed of common household materials was developed at Oak Ridge National Laboratory (ORNL) by Cresson H. Kearny and has been referred to as the Kearny Fallout Meter (KFM). Developed during the height of the Cold War, the KFM was intended to place a radiation meter capable of measuring fallout...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200411002-00006

    authors: McDonald JT,West WG,Kearfott KJ

    更新日期:2004-11-01 00:00:00

  • The H-ARS Dose Response Relationship (DRR): Validation and Variables.

    abstract::Manipulations of lethally-irradiated animals, such as for administration of pharmaceuticals, blood sampling, or other laboratory procedures, have the potential to induce stress effects that may negatively affect morbidity and mortality. To investigate this in a murine model of the hematopoietic acute radiation syndrom...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000354

    authors: Plett PA,Sampson CH,Chua HL,Jackson W,Vemula S,Sellamuthu R,Fisher A,Feng H,Wu T,MacVittie TJ,Orschell CM

    更新日期:2015-11-01 00:00:00

  • Distribution of radiocesium in the soil-plant systems of upland areas of Europe.

    abstract::The distribution and behavior of Cs in the soil-plant systems at some upland sites in Northeastern Italy, Scotland, and Norway have been investigated. From the limited range of samples taken, there appears to be no dominant physicochemical control on the plant availability of Cs. The presence of micaceous minerals or ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199104000-00008

    authors: Livens FR,Horrill AD,Singleton DL

    更新日期:1991-04-01 00:00:00

  • Measurement of outdoor terrestrial gamma radiation in the Sultanate of Oman.

    abstract::The terrestrial gamma radiation level was determined throughout the Sultanate of Oman over a 3-y period. The dose rate at 1 m above the ground was measured at 512 locations using a compensated Geiger-Miller detector. The activity concentration of soil/rock samples, collected from 112 locations, was determined by gamma...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200206000-00016

    authors: Goddard CC

    更新日期:2002-06-01 00:00:00

  • Radon entry into houses: the importance of scale-dependent permeability.

    abstract::Soil permeability to air can increase substantially with measurement length scale. We tested the hypothesis that the scale effect could resolve large model underpredictions of radon and soil-gas entry into two experimental basement structures located in natural sandy-loam soil at a field site in Ben Lomond, CA. Previo...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199908000-00008

    authors: Garbesi K,Robinson AL,Sextro RG,Nazaroff WW

    更新日期:1999-08-01 00:00:00

  • Pasture practices, milk distribution, and consumption in the continental U.S. in the 1950s.

    abstract::Determining the consumption of milk contaminated with 131I, resulting from atmospheric nuclear weapons tests conducted at the Nevada Test Site, by the United States population during the 1950s constitutes one part of the methodology used by the National Cancer Institute to assess radiation exposures to Americans. In o...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199011000-00013

    authors: Dreicer M,Bouville A,Wachholz BW

    更新日期:1990-11-01 00:00:00

  • Radon in outdoor air in Nevada.

    abstract::Measurements of radon at 50 sites with varying geology indicate that outdoor air in Nevada is comparable to that measured nationwide by Hopper et al. (1991). The statewide median of 15 Bq m-3 (0.4 pCi L-1) is essentially the same as the nationwide median. The range is considerable: from 2.6-52 Bq m-3 (0.07-1.40 pCi L-...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199404000-00009

    authors: Price JG,Rigby JG,Christensen L,Hess R,LaPointe DD,Ramelli AR,Desilets M,Hopper RD,Kluesner T,Marshall S

    更新日期:1994-04-01 00:00:00

  • Determination of the shielding for an unoccupied roof of a radiation therapy facility to account for adjacent buildings--modification of a computer program.

    abstract::An addition has been made to an existing software program for calculating shielding thicknesses of barriers for megavoltage radiation therapy beams. This addition calculates the shielding thicknesses required for the roof of a single-story building when adjacent, multi-level buildings are occupied. ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199810000-00013

    authors: Biggs PJ

    更新日期:1998-10-01 00:00:00

  • A passive diffusion 222Rn sampler based on activated carbon adsorption.

    abstract::A simple passive sampler for 222Rn with up to 24-hr integration times can be constructed by using a diffusion barrier to regulate the effective sampling rate of an ambient temperature activated carbon bed. The diffusion element serves to make sampler performance relatively independent of the properties of the type of ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198506000-00007

    authors: Prichard HM,Mariën K

    更新日期:1985-06-01 00:00:00

  • The beagle: an appropriate experimental animal for extrapolating the organ distribution pattern of Th in humans.

    abstract::The concentrations and the organ distribution patterns of 228Th, 230Th and 232Th in two 9-y-old dogs of our beagle colony were determined. The dogs were exposed only to background environmental levels of Th isotopes through ingestion (food and water) and inhalation as are humans. The organ distribution patterns of the...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198803000-00006

    authors: Singh NP,Zimmerman CJ,Taylor GN,Wrenn ME

    更新日期:1988-03-01 00:00:00

  • Application of in-vitro bioassay for 137Cs during the emergency phase of the Goiânia accident.

    abstract::In the Goiânia accident, many individuals suffered external and internal contamination. The screening of internal contamination was done through 137Cs urinary excretion. During the first month after the accident, only in-vitro bioassay procedures were done. Incorporation into the body and committed doses were estimate...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199101000-00006

    authors: Lipsztein JL,Bertelli L,Melo DR,Azeredo AM,Julião L,Santos MS

    更新日期:1991-01-01 00:00:00

  • Urinary uranium concentrations in an enlarged Gulf War veteran cohort.

    abstract::Depleted uranium was first used on a large scale as a major component of munitions and armaments employed by the U.S. armed forces during the Gulf War in 1991. In response to concern that exposure to depleted uranium may have been a cause of health problems suffered by returning veterans of that war, an already existi...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200103000-00010

    authors: McDiarmid MA,Engelhardt SM,Oliver M

    更新日期:2001-03-01 00:00:00