Delayed Effects of Acute Radiation Exposure in a Murine Model of the H-ARS: Multiple-Organ Injury Consequent to

Abstract:

:The threat of radiation exposure from warfare or radiation accidents raises the need for appropriate animal models to study the acute and chronic effects of high dose rate radiation exposure. The goal of this study was to assess the late development of fibrosis in multiple organs (kidney, heart, and lung) in survivors of the C57BL/6 mouse model of the hematopoietic-acute radiation syndrome (H-ARS). Separate groups of mice for histological and functional studies were exposed to a single uniform total body dose between 8.53 and 8.72 Gy of gamma radiation from a Cs radiation source and studied 1-21 mo later. Blood urea nitrogen levels were elevated significantly in the irradiated mice at 9 and 21 mo (from ∼22 to 34 ± 3.8 and 69 ± 6.0 mg dL, p < 0.01 vs. non-irradiated controls) and correlated with glomerosclerosis (29 ± 1.8% vs. 64 ± 9.7% of total glomeruli, p < 0.01 vs. non-irradiated controls). Glomerular tubularization and hypertrophy and tubular atrophy were also observed at 21 mo post-total body irradiation (TBI). An increase in interstitial, perivascular, pericardial and peribronchial fibrosis/collagen deposition was observed from ∼9-21 mo post-TBI in kidney, heart, and lung of irradiated mice relative to age-matched controls. Echocardiography suggested decreased ventricular volumes with a compensatory increase in the left ventricular ejection fraction. The results indicate that significant delayed effects of acute radiation exposure occur in kidney, heart, and lung in survivors of the murine H-ARS TBI model, which mirrors pathology detected in larger species and humans at higher radiation doses focused on specific organs.

journal_name

Health Phys

journal_title

Health physics

authors

Unthank JL,Miller SJ,Quickery AK,Ferguson EL,Wang M,Sampson CH,Chua HL,DiStasi MR,Feng H,Fisher A,Katz BP,Plett PA,Sandusky GE,Sellamuthu R,Vemula S,Cohen EP,MacVittie TJ,Orschell CM

doi

10.1097/HP.0000000000000357

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

511-21

issue

5

eissn

0017-9078

issn

1538-5159

pii

00004032-201511000-00015

journal_volume

109

pub_type

杂志文章
  • Performance of a diffusion barrier charcoal adsorption 222Rn monitor under conditions of varying humidity and temperature.

    abstract::An investigation of the performance of a diffusion barrier, charcoal-based 222Rn monitor under several artificial environmental conditions showed that both temperature and relative humidity levels affect 222Rn uptake. A physical model was developed adequately describing the temperature effects, while an empirical mode...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199001000-00002

    authors: Pojer PM,Peggie JR,O'Brien RS,Solomon SB,Wise KN

    更新日期:1990-01-01 00:00:00

  • Fourteenth Annual Warren K. Sinclair Keynote Address: Aren't We Ready Yet? Closing the Planning, Response, and Recovery Gaps for Radiological Terrorism.

    abstract::Following the tragic events of 11 September 2001, the nation has made significant strides in preparing for disasters and emergencies of all types. Federal funding to state, local, territorial, and tribal public health and healthcare systems has required an all-hazards preparedness approach with special focus on those ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000754

    authors: Herrmann J

    更新日期:2018-02-01 00:00:00

  • Fallout 239/240Pu and 238Pu in human tissues from the Federal Republic of Germany.

    abstract::To determine the present level of plutonium in human tissues of people in the F.R.G., due solely to fallout from weapons testing, 30 sets of tissues and bones from Munich residents were obtained at autopsy. Each set of tissues consisted of the entire lung, the entire liver, 300 g vertebrae, 300 g ribs and the lymph no...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198306001-00042

    authors: Bunzl K,Kracke W

    更新日期:1983-01-01 00:00:00

  • The LLNL voxel phantom: comparison with the physical phantom and previous virtual phantoms.

    abstract::The Human Monitoring Laboratory has created a voxel phantom from computer tomography scans of the Lawrence Livermore National Laboratory (LLNL) torso phantom for use in Monte Carlo simulations. The voxel phantom has been compared to the previously developed mathematical phantom using Monte Carlo simulations and both v...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000269515.90175.86

    authors: Kramer GH,Capello K,Sung J

    更新日期:2007-12-01 00:00:00

  • Radiation safety considerations for the use of ²²³RaCl₂ DE in men with castration-resistant prostate cancer.

    abstract::The majority of patients with late stage castration-resistant prostate cancer (CRPC) develop bone metastases that often result in significant bone pain. Therapeutic palliation strategies can delay or prevent skeletal complications and may prolong survival. An alpha-particle based therapy, radium-223 dichloride (²²³RaC...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3182a82b37

    authors: Dauer LT,Williamson MJ,Humm J,O'Donoghue J,Ghani R,Awadallah R,Carrasquillo J,Pandit-Taskar N,Aksnes AK,Biggin C,Reinton V,Morris M,St Germain J

    更新日期:2014-04-01 00:00:00

  • A review of countermeasures to reduce radioiodine in milk of dairy animals.

    abstract::The most effective countermeasure for radioiodine contamination of milk is to provide dairy animals with uncontaminated feed, with the added advantage that it will be effective for other radionuclides in the fallout. Another effective response is to process the milk into storable dairy products for an appropriate leng...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199611000-00005

    authors: Howard BJ,Voigt G,Segal MG,Ward GM

    更新日期:1996-11-01 00:00:00

  • Assessing the renal toxicity of Capstone depleted uranium oxides and other uranium compounds.

    abstract::The primary target for uranium toxicity is the kidney. The most frequently used guideline for uranium kidney burdens is the International Commission on Radiological Protection value of 3 microg U g(-1) kidney, a value that is based largely upon chronic studies in animals. In the present effort, a risk model equation w...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000338421.07312.ed

    authors: Roszell LE,Hahn FF,Lee RB,Parkhurst MA

    更新日期:2009-03-01 00:00:00

  • Organ Doses From Diagnostic Medical Radiography-Trends Over Eight Decades (1930 to 2010).

    abstract::This study provides a retrospective assessment of doses to 13 organs for the most common radiographic examinations conducted between the 1930s and 2010, taking into account typical technical parameters used for radiography during those years. This study is intended to be a resource on changes in medical diagnostic rad...

    journal_title:Health physics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/HP.0000000000000524

    authors: Melo DR,Miller DL,Chang L,Moroz B,Linet MS,Simon SL

    更新日期:2016-09-01 00:00:00

  • Background atmospheric 222Rn concentrations outdoors and indoors: a review.

    abstract::The sources of outdoor and indoor atmospheric radon are examined. The variation of outdoor atmospheric radon with time of day, time of year, altitude and geographic location is quantitatively assessed. Average values of outdoor atmospheric radon concentrations are examined and it is estimated that the mean value for n...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198308000-00002

    authors: Gesell TF

    更新日期:1983-08-01 00:00:00

  • Sorption of tin on human teeth.

    abstract::The sorption of tin ions on human teeth from water and other drinks has been studied by the radioactive tracer technique using the isotope 113Sn (T(1/2) = 115.1 d) as a tracer. The tooth holds a minimum amount of tin from coffee and a maximum amount is held from water and from tea with sugar. The same technique was al...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200201000-00014

    authors: Helal AA,Alian GA,Madbouly HA

    更新日期:2002-01-01 00:00:00

  • Determination of natural radionuclides content in some building materials in Nigeria by gamma-ray spectrometry.

    abstract::This paper presents the findings of a study undertaken to determine the natural radioactivity present in some building materials in Nigeria using a gamma-ray spectrometer with a hyper pure germanium detector. A total of 118 samples of commonly used building materials were collected from manufacturers and suppliers of ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000279601.26386.af

    authors: Ademola JA

    更新日期:2008-01-01 00:00:00

  • Reassessment of Internal Thyroid Doses to 1,080 Children Examined in a Screening Survey after the 2011 Fukushima Nuclear Disaster.

    abstract::The dose reconstruction of populations potentially affected by the accident at the Fukushima Daiichi nuclear power plant in March 2011 is of great importance. However, it has been difficult to assess internal thyroid doses to Fukushima residents (mainly from their intake of I) due to the lack of direct measurements. F...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001125

    authors: Kim E,Yajima K,Hashimoto S,Tani K,Igarashi Y,Iimoto T,Ishigure N,Tatsuzaki H,Akashi M,Kurihara O

    更新日期:2020-01-01 00:00:00

  • Theoretical study of the relation between radon and its long-lived progeny in a room.

    abstract::We present a theoretical study of the complex relation between radon and its long-lived progeny implanted in glass surfaces. The well known (extended) Jacobi room model, which is normally used to describe radon and its progeny in a room, was transformed into a two-parameter model revealing a linear correlation between...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200010000-00006

    authors: Cauwels P,Poffijn A,Mondelaers W,Lahorte P,Masschaele B,Meesen G,Van Deynse A

    更新日期:2000-10-01 00:00:00

  • Preconceptional paternal exposure to depleted uranium: transmission of genetic damage to offspring.

    abstract::Depleted uranium (DU) is an alpha particle emitter and radioactive heavy metal used in military applications. Due to internalization of DU during military operations and the ensuing chronic internal exposure to DU, there are concerns regarding its potential health effects. Preconceptional paternal irradiation has been...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181cfe0dd

    authors: Miller AC,Stewart M,Rivas R

    更新日期:2010-09-01 00:00:00

  • A constant flow filter air sampler for workplace environments.

    abstract::A filter air sampler has been developed for sampling radionuclide aerosol particles from the workplace environment. It provides easy filter changing, constant flow sampling, and a visual display to indicate proper operation. An experimental study was conducted to characterize the collection efficiency of the sampler a...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199612000-00003

    authors: Parulian A,Rodgers JC,McFarland AR

    更新日期:1996-12-01 00:00:00

  • Sensitivity of portable personnel portal monitors: potential problems when dealing with contaminated persons.

    abstract::Health physicists are usually concerned with small amounts of radioactivity and strive to develop techniques to measure them; however, following a terrorist attack involving radioactive materials the converse might be the case, and exposed persons may be heavily contaminated. The Human Monitoring Laboratory (HML) has ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.HP.0000218425.48988.f3

    authors: Kramer GH,Capello K,Hauck BM,Brown JT

    更新日期:2006-10-01 00:00:00

  • Security of radioactive material at academic institutions.

    abstract::In recent years, regulatory emphasis on the prevention of loss, theft and intentional misuse of radioactive materials at academic institutions has forced radiation safety personnel to devote increasing amounts of time and effort to address security issues. NRC regulations require that radioactive materials used or sto...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200311002-00009

    authors: Farley DV,Normandin RD,Martz MD,Langhorst SM

    更新日期:2003-11-01 00:00:00

  • An investigation into the prevalence of thyroid disease on Kwajalein Atoll, Marshall Islands.

    abstract::The prevalence of thyroid nodules and thyroid cancer was studied in the indigenous population residing on Ebeye Island, Kwajalein Atoll, in the Republic of the Marshall Islands. This island, centrally located in the nation, is home to about 25% of the nation's population, many who have migrated there from other atolls...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199707000-00017

    authors: Takahashi T,Trott KR,Fujimori K,Simon SL,Ohtomo H,Nakashima N,Takaya K,Kimura N,Satomi S,Schoemaker MJ

    更新日期:1997-07-01 00:00:00

  • Differences in lung cancer mortality trends from 1986-2012 by radon risk areas in British Columbia, Canada.

    abstract::Residential exposure to radon gas is associated with increased risk of lung cancer, especially in smokers. Most evidence about the health effects of radon has been derived from meta-analyses on global epidemiologic studies, but administrative data can help public health authorities to explore the local impacts. Eighty...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000005

    authors: Henderson SB,Rauch SA,Hystad P,Kosatsky T

    更新日期:2014-05-01 00:00:00

  • In Vivo Electron Paramagnetic Resonance Tooth Dosimetry: Dependence of Radiation-Induced Signal Amplitude on the Enamel Thickness and Surface Area of Ex Vivo Human Teeth.

    abstract::In vivo L-band electron paramagnetic resonance tooth dosimetry is a newly developed and very promising method for retrospective biodosimetry in individuals who may have been exposed to significant levels of ionizing radiation. The present study aimed to determine the relationships among enamel thickness, enamel area, ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000698

    authors: Umakoshi M,Yamaguchi I,Hirata H,Kunugita N,Williams BB,Swartz HM,Miyake M

    更新日期:2017-10-01 00:00:00

  • Radiological findings of accidental radiation injury of the fingers: a case report.

    abstract::This case report describes the medical follow-up of a 46-y-old (at the time of exposure) man who in 1971 accidentally exposed the fingers of his right hand to gamma-ray radiation from an iridium source that was used for nondestructive testing [estimated radiation dose: 26 Gy to 90 Gy (2,600 rad to 9,000 rad)]. No prom...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200101000-00012

    authors: Nakagawa K,Kozuka T,Akahane M,Suzuki G,Akashi M,Hosoi Y,Aoki Y,Ohtomo K

    更新日期:2001-01-01 00:00:00

  • One-dimensional Spatial Distributions of Gamma-ray Emitting Contaminants in Field Lysimeters Using a Collimated Gamma-ray Spectroscopy System.

    abstract::One-dimensional scans of gamma-ray emitting contaminants were conducted on lysimeters from the RadFLEX facility at the Savannah River Nationals Laboratory (SRNL). The lysimeters each contained a contamination source that was buried in SRNL soil. A source consisted of Cs, Co, Ba, and Eu incorporated either into a solid...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000799

    authors: Erdmann BJ,Powell BA,Kaplan DI,DeVol TA

    更新日期:2018-05-01 00:00:00

  • Test of the linear-no threshold theory of radiation carcinogenesis for inhaled radon decay products.

    abstract::Data on lung cancer mortality rates vs. average radon concentration in homes for 1,601 U.S. counties are used to test the linear-no threshold theory. The widely recognized problems with ecological studies, as applied to this work, are addressed extensively. With or without corrections for variations in smoking prevale...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199502000-00002

    authors: Cohen BL

    更新日期:1995-02-01 00:00:00

  • Retention and dosimetry of 106Ru inhaled along with inert particles by Fischer-344 rats.

    abstract::This study was done to provide data useful for predicting the deposition, retention and radiation dose patterns for humans who might be exposed to an aerosol containing 106RuO4 and respirable particles. Ruthenium-106 tetroxide was introduced into air containing inert particles. The inert particles were monodisperse. 0...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198304000-00003

    authors: Snipes MB,Kanapilly GM

    更新日期:1983-04-01 00:00:00

  • Intercomparison of Commercially Available Active Radon Measurement Devices in a Discovered Radon Chamber.

    abstract::An unventilated 70 m underground space, with 2.1 m high ceilings and an inner set of concrete walls to damp vibrations, was discovered to have relatively stable radon levels of ~1,080 Bq m over a 1-y period. The addition of radium sources was not required to achieve high and somewhat variable radon levels, as these ar...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001047

    authors: Carmona MA,Kearfott KJ

    更新日期:2019-06-01 00:00:00

  • Summertime elevation of 222Rn levels in Huntsville, Alabama.

    abstract::Indoor Rn concentrations and Rn in adjacent karst terrains were studied at four houses with crawlspaces in Huntsville, AL. In warm summertime weather, Rn-rich air may vent through limestone solution cavities exposed as holes at the surface of the properties. A probable interrelated-finding is that the indoor levels of...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199102000-00006

    authors: Wilson DL,Gammage RB,Dudney CS,Saultz RJ

    更新日期:1991-02-01 00:00:00

  • Calculation of immersion doses from external exposure to a plume of radioactive material.

    abstract::The immersion doses from external exposure to a Gaussian plume of noble gases accidentally released into the atmosphere have been calculated. A numerical integration procedure employing Gauss-Legendre of 64th order has been used. The numerical procedure allows calculating the dose rate at any downwind horizontal or ve...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.hp.0000165448.00478.f9

    authors: Raza S,Avila R

    更新日期:2005-09-01 00:00:00

  • Trends and Distribution Analysis of Occupational Exposure From Medical Practices in China (2010-2016).

    abstract::Occupational exposure to ionizing radiation from medical practices in China has been collected for a 7 y period between 2010 and 2016 from roughly 220 individual monitoring service providers through the Chinese Registry of Radiation Workers. Statistical dose distributions and characteristic tendencies are presented ba...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001118

    authors: Deng J,Fan S,Wang T,Hao S,Liu X,Guo W,Sun Q

    更新日期:2019-12-01 00:00:00

  • Radiation Brain Drain? The Impact of Demographic Change on U.S. Radiation Protection.

    abstract::The use of radiation has a substantial beneficial impact, particularly in the areas of medicine, energy production, basic science research, and industrial applications. Radiation protection knowledge and experience are required for acquiring and implementing scientific knowledge to protect workers, members of the publ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000602

    authors: Hricak H,Dauer LT

    更新日期:2017-02-01 00:00:00

  • Enhanced Radioactive Material Source Security.

    abstract::Requirements for additional security measures for sealed radioactive sources have evolved since they were first implemented after the terrorist events of 11 September 2001. This paper will describe the sequence of those measures, commencing with the early orders issued by the U.S. Nuclear Regulatory Commission to the ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000397

    authors: Klinger JG

    更新日期:2016-02-01 00:00:00