Abstract:
:The threat of radiation exposure from warfare or radiation accidents raises the need for appropriate animal models to study the acute and chronic effects of high dose rate radiation exposure. The goal of this study was to assess the late development of fibrosis in multiple organs (kidney, heart, and lung) in survivors of the C57BL/6 mouse model of the hematopoietic-acute radiation syndrome (H-ARS). Separate groups of mice for histological and functional studies were exposed to a single uniform total body dose between 8.53 and 8.72 Gy of gamma radiation from a Cs radiation source and studied 1-21 mo later. Blood urea nitrogen levels were elevated significantly in the irradiated mice at 9 and 21 mo (from ∼22 to 34 ± 3.8 and 69 ± 6.0 mg dL, p < 0.01 vs. non-irradiated controls) and correlated with glomerosclerosis (29 ± 1.8% vs. 64 ± 9.7% of total glomeruli, p < 0.01 vs. non-irradiated controls). Glomerular tubularization and hypertrophy and tubular atrophy were also observed at 21 mo post-total body irradiation (TBI). An increase in interstitial, perivascular, pericardial and peribronchial fibrosis/collagen deposition was observed from ∼9-21 mo post-TBI in kidney, heart, and lung of irradiated mice relative to age-matched controls. Echocardiography suggested decreased ventricular volumes with a compensatory increase in the left ventricular ejection fraction. The results indicate that significant delayed effects of acute radiation exposure occur in kidney, heart, and lung in survivors of the murine H-ARS TBI model, which mirrors pathology detected in larger species and humans at higher radiation doses focused on specific organs.
journal_name
Health Physjournal_title
Health physicsauthors
Unthank JL,Miller SJ,Quickery AK,Ferguson EL,Wang M,Sampson CH,Chua HL,DiStasi MR,Feng H,Fisher A,Katz BP,Plett PA,Sandusky GE,Sellamuthu R,Vemula S,Cohen EP,MacVittie TJ,Orschell CMdoi
10.1097/HP.0000000000000357subject
Has Abstractpub_date
2015-11-01 00:00:00pages
511-21issue
5eissn
0017-9078issn
1538-5159pii
00004032-201511000-00015journal_volume
109pub_type
杂志文章相关文献
HEALTH PHYSICS文献大全abstract::An investigation of the performance of a diffusion barrier, charcoal-based 222Rn monitor under several artificial environmental conditions showed that both temperature and relative humidity levels affect 222Rn uptake. A physical model was developed adequately describing the temperature effects, while an empirical mode...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199001000-00002
更新日期:1990-01-01 00:00:00
abstract::Following the tragic events of 11 September 2001, the nation has made significant strides in preparing for disasters and emergencies of all types. Federal funding to state, local, territorial, and tribal public health and healthcare systems has required an all-hazards preparedness approach with special focus on those ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000754
更新日期:2018-02-01 00:00:00
abstract::To determine the present level of plutonium in human tissues of people in the F.R.G., due solely to fallout from weapons testing, 30 sets of tissues and bones from Munich residents were obtained at autopsy. Each set of tissues consisted of the entire lung, the entire liver, 300 g vertebrae, 300 g ribs and the lymph no...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198306001-00042
更新日期:1983-01-01 00:00:00
abstract::The Human Monitoring Laboratory has created a voxel phantom from computer tomography scans of the Lawrence Livermore National Laboratory (LLNL) torso phantom for use in Monte Carlo simulations. The voxel phantom has been compared to the previously developed mathematical phantom using Monte Carlo simulations and both v...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/01.HP.0000269515.90175.86
更新日期:2007-12-01 00:00:00
abstract::The majority of patients with late stage castration-resistant prostate cancer (CRPC) develop bone metastases that often result in significant bone pain. Therapeutic palliation strategies can delay or prevent skeletal complications and may prolong survival. An alpha-particle based therapy, radium-223 dichloride (²²³RaC...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0b013e3182a82b37
更新日期:2014-04-01 00:00:00
abstract::The most effective countermeasure for radioiodine contamination of milk is to provide dairy animals with uncontaminated feed, with the added advantage that it will be effective for other radionuclides in the fallout. Another effective response is to process the milk into storable dairy products for an appropriate leng...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199611000-00005
更新日期:1996-11-01 00:00:00
abstract::The primary target for uranium toxicity is the kidney. The most frequently used guideline for uranium kidney burdens is the International Commission on Radiological Protection value of 3 microg U g(-1) kidney, a value that is based largely upon chronic studies in animals. In the present effort, a risk model equation w...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/01.HP.0000338421.07312.ed
更新日期:2009-03-01 00:00:00
abstract::This study provides a retrospective assessment of doses to 13 organs for the most common radiographic examinations conducted between the 1930s and 2010, taking into account typical technical parameters used for radiography during those years. This study is intended to be a resource on changes in medical diagnostic rad...
journal_title:Health physics
pub_type: 杂志文章,meta分析,评审
doi:10.1097/HP.0000000000000524
更新日期:2016-09-01 00:00:00
abstract::The sources of outdoor and indoor atmospheric radon are examined. The variation of outdoor atmospheric radon with time of day, time of year, altitude and geographic location is quantitatively assessed. Average values of outdoor atmospheric radon concentrations are examined and it is estimated that the mean value for n...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198308000-00002
更新日期:1983-08-01 00:00:00
abstract::The sorption of tin ions on human teeth from water and other drinks has been studied by the radioactive tracer technique using the isotope 113Sn (T(1/2) = 115.1 d) as a tracer. The tooth holds a minimum amount of tin from coffee and a maximum amount is held from water and from tea with sugar. The same technique was al...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-200201000-00014
更新日期:2002-01-01 00:00:00
abstract::This paper presents the findings of a study undertaken to determine the natural radioactivity present in some building materials in Nigeria using a gamma-ray spectrometer with a hyper pure germanium detector. A total of 118 samples of commonly used building materials were collected from manufacturers and suppliers of ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/01.HP.0000279601.26386.af
更新日期:2008-01-01 00:00:00
abstract::The dose reconstruction of populations potentially affected by the accident at the Fukushima Daiichi nuclear power plant in March 2011 is of great importance. However, it has been difficult to assess internal thyroid doses to Fukushima residents (mainly from their intake of I) due to the lack of direct measurements. F...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000001125
更新日期:2020-01-01 00:00:00
abstract::We present a theoretical study of the complex relation between radon and its long-lived progeny implanted in glass surfaces. The well known (extended) Jacobi room model, which is normally used to describe radon and its progeny in a room, was transformed into a two-parameter model revealing a linear correlation between...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-200010000-00006
更新日期:2000-10-01 00:00:00
abstract::Depleted uranium (DU) is an alpha particle emitter and radioactive heavy metal used in military applications. Due to internalization of DU during military operations and the ensuing chronic internal exposure to DU, there are concerns regarding its potential health effects. Preconceptional paternal irradiation has been...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0b013e3181cfe0dd
更新日期:2010-09-01 00:00:00
abstract::A filter air sampler has been developed for sampling radionuclide aerosol particles from the workplace environment. It provides easy filter changing, constant flow sampling, and a visual display to indicate proper operation. An experimental study was conducted to characterize the collection efficiency of the sampler a...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199612000-00003
更新日期:1996-12-01 00:00:00
abstract::Health physicists are usually concerned with small amounts of radioactivity and strive to develop techniques to measure them; however, following a terrorist attack involving radioactive materials the converse might be the case, and exposed persons may be heavily contaminated. The Human Monitoring Laboratory (HML) has ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/01.HP.0000218425.48988.f3
更新日期:2006-10-01 00:00:00
abstract::In recent years, regulatory emphasis on the prevention of loss, theft and intentional misuse of radioactive materials at academic institutions has forced radiation safety personnel to devote increasing amounts of time and effort to address security issues. NRC regulations require that radioactive materials used or sto...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-200311002-00009
更新日期:2003-11-01 00:00:00
abstract::The prevalence of thyroid nodules and thyroid cancer was studied in the indigenous population residing on Ebeye Island, Kwajalein Atoll, in the Republic of the Marshall Islands. This island, centrally located in the nation, is home to about 25% of the nation's population, many who have migrated there from other atolls...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199707000-00017
更新日期:1997-07-01 00:00:00
abstract::Residential exposure to radon gas is associated with increased risk of lung cancer, especially in smokers. Most evidence about the health effects of radon has been derived from meta-analyses on global epidemiologic studies, but administrative data can help public health authorities to explore the local impacts. Eighty...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000005
更新日期:2014-05-01 00:00:00
abstract::In vivo L-band electron paramagnetic resonance tooth dosimetry is a newly developed and very promising method for retrospective biodosimetry in individuals who may have been exposed to significant levels of ionizing radiation. The present study aimed to determine the relationships among enamel thickness, enamel area, ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000698
更新日期:2017-10-01 00:00:00
abstract::This case report describes the medical follow-up of a 46-y-old (at the time of exposure) man who in 1971 accidentally exposed the fingers of his right hand to gamma-ray radiation from an iridium source that was used for nondestructive testing [estimated radiation dose: 26 Gy to 90 Gy (2,600 rad to 9,000 rad)]. No prom...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-200101000-00012
更新日期:2001-01-01 00:00:00
abstract::One-dimensional scans of gamma-ray emitting contaminants were conducted on lysimeters from the RadFLEX facility at the Savannah River Nationals Laboratory (SRNL). The lysimeters each contained a contamination source that was buried in SRNL soil. A source consisted of Cs, Co, Ba, and Eu incorporated either into a solid...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000799
更新日期:2018-05-01 00:00:00
abstract::Data on lung cancer mortality rates vs. average radon concentration in homes for 1,601 U.S. counties are used to test the linear-no threshold theory. The widely recognized problems with ecological studies, as applied to this work, are addressed extensively. With or without corrections for variations in smoking prevale...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199502000-00002
更新日期:1995-02-01 00:00:00
abstract::This study was done to provide data useful for predicting the deposition, retention and radiation dose patterns for humans who might be exposed to an aerosol containing 106RuO4 and respirable particles. Ruthenium-106 tetroxide was introduced into air containing inert particles. The inert particles were monodisperse. 0...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-198304000-00003
更新日期:1983-04-01 00:00:00
abstract::An unventilated 70 m underground space, with 2.1 m high ceilings and an inner set of concrete walls to damp vibrations, was discovered to have relatively stable radon levels of ~1,080 Bq m over a 1-y period. The addition of radium sources was not required to achieve high and somewhat variable radon levels, as these ar...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000001047
更新日期:2019-06-01 00:00:00
abstract::Indoor Rn concentrations and Rn in adjacent karst terrains were studied at four houses with crawlspaces in Huntsville, AL. In warm summertime weather, Rn-rich air may vent through limestone solution cavities exposed as holes at the surface of the properties. A probable interrelated-finding is that the indoor levels of...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/00004032-199102000-00006
更新日期:1991-02-01 00:00:00
abstract::The immersion doses from external exposure to a Gaussian plume of noble gases accidentally released into the atmosphere have been calculated. A numerical integration procedure employing Gauss-Legendre of 64th order has been used. The numerical procedure allows calculating the dose rate at any downwind horizontal or ve...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/01.hp.0000165448.00478.f9
更新日期:2005-09-01 00:00:00
abstract::Occupational exposure to ionizing radiation from medical practices in China has been collected for a 7 y period between 2010 and 2016 from roughly 220 individual monitoring service providers through the Chinese Registry of Radiation Workers. Statistical dose distributions and characteristic tendencies are presented ba...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000001118
更新日期:2019-12-01 00:00:00
abstract::The use of radiation has a substantial beneficial impact, particularly in the areas of medicine, energy production, basic science research, and industrial applications. Radiation protection knowledge and experience are required for acquiring and implementing scientific knowledge to protect workers, members of the publ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000602
更新日期:2017-02-01 00:00:00
abstract::Requirements for additional security measures for sealed radioactive sources have evolved since they were first implemented after the terrorist events of 11 September 2001. This paper will describe the sequence of those measures, commencing with the early orders issued by the U.S. Nuclear Regulatory Commission to the ...
journal_title:Health physics
pub_type: 杂志文章
doi:10.1097/HP.0000000000000397
更新日期:2016-02-01 00:00:00